Beneficial effects of colchicine on 17α-ethynylestradiol-induced cholestasis in rats

Arzneimittel-Forschung/Drug Research

Volumn 61, Issue 3, 2011, Pages 173-179

  Zhou, Zhi Xing ^a   Wang, Tao ^a   Jiang, Zhen Zhou ^a   Shang, Jing ^a   Liu, Li ^a,b   Zhang, Yue ^a   Zhu, Dan ^a   Huang, Xiao ^a   Zhang, Shuang ^a   Hu, Yue ^a   Wang, Jia Ying ^a   Zhang, Lu Yong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b YANGZHOU UNIVERSITY   (China)

Author keywords

Bile salt export pump; CAS 64 86 8; Cholestasis; Cholesterol 7 hydroxylase; Colchicine; Farnesoid X receptor; Multidrug resistance associated protein 2

Indexed keywords

BILE SALT; CAS 64 86 8; CHOLESTEROL 7ALPHA MONOOXYGENASE; COLCHICINE; ETHINYLESTRADIOL; FARNESOID X RECEPTOR; MULTIDRUG RESISTANCE PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; BILE FLOW; BILIARY EXCRETION; BODY WEIGHT; CHOLESTASIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BLOOD LEVEL; LIVER WEIGHT; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

EID: 79953253401     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296185     Document Type: Article

References (36)

1. Schreiber AJ, Simon FR. Estrogen-induced cholestasis: clues to pathogenesis and treatment. Hepatology. 1983;3:607-13. (Pubitemid 13078764)
2. Gumucio JJ, Valdivieso VD. Studies on the mechanism of the ethynylestradiol impairment of bile flow and bile salt excretion in the rat. Gastroenterology. 1971;61:339-44.
3. Crocenzi FA, Sanchez Pozzi EJ, Pellegrino JM, Favre CO, Rodriguez Garay EA, Mottino AD, et al. Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets. Hepatology. 2001;34:329-39. (Pubitemid 32702346)
4. Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL. Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology. 2000;118:163-72. (Pubitemid 30020384)
5. Trauner M, Arrese M, Soroka CJ, Ananthanarayanan M, Koeppel TA, Schlosser SF, et al. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology. 1997;113:255-64. (Pubitemid 27281782)
6. Le Marchand Y, Singh A, Assimacopoulos-Jeannet F, Orci L, Rouiller C, Jeanrenaud B. A role for the microtubular system in the release of very low density lipoproteins by perfused mouse livers. J Biol Chem. 1973;248:6862-70.
7. Lee YM, Kaplan MM. Efficacy of colchicine in patients with primary biliary cirrhosis poorly responsive to ursodiol and methotrexate. AmJ Gastroenterol. 2003;98:205-8. (Pubitemid 36135193)
8. Muriel P, Rivera-Espinoza Y. Beneficial drugs for liver diseases. J Appl Toxicol. 2008;28:93-103. (Pubitemid 351428281)
9. Malawista SE. Colchicine: a common mechanism for its anti-inflammatory and anti-mitotic effec-ts. Arthritis Rheum. 1968;11:191-7.
10. Poo JL, Feldmann G, Moreau A, Gaudin C, Lebrec D. Early colchicine administration reduces hepatic fibrosis and portal hypertension in rats with bile duct ligation. J Hepatol. 1993;19:90-4. (Pubitemid 23338016)
11. Mourelle M, Meza MA. Colchicine prevents D-galactosamine- induced hepatitis. J Hepatol. 1989;8:165-72. (Pubitemid 19074353)
12. Muriel P, Quintanar ME, Perez-Alvarez V. Effect of colchicine on acetaminophen-induced liver damage. Liver. 1993; 13:217-21. (Pubitemid 23268422)
13. Dubin M, Maurice M, Feldmann G, Erlinger S. Influence of colchicine and phalloidin on bile secretion and hepatic ultrastructure in the rat. Possible interaction between microtubules and microfilaments. Gastroenterology. 1980;79: 646-54.
14. Barnwell SG, Lowe PJ, Coleman R. The effects of colchicine on secretion into bile of bile salts, phospholipids, cholesterol and plasma membrane enzymes: bile salts are secreted unaccompanied by phospholipids and cholesterol. Biochem J. 1984;220:723-31. (Pubitemid 14121372)
15. Crawford JM, Berken CA, Gollan JL. Role of the hepatocyte microtubular system in the excreti-on of bile salts and biliary lipid: implications for intracellular vesicular transport. J Lipid Res. 1988;29:144-56.
16. Barnwell SG, Yousef IM, Tuchweber B. The effect of colchicine on the development of lithochol-ic acid-induced cholestasis. A study of the role of microtubules in intracellular cholesterol transport. Biochem J. 1986;236:345-50.
17. Takikawa H, Sano N, Yamazaki R, Yamanaka M. Colchicine inhibits lithocholate-3-O-glucuroni-de-induced cholestasis in rats. J Hepatol. 1995;22:88-93.
18. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidi-zed glutathione: applications to mammalian blood and other tissues. Anal Biochem. 1969;27:502-22.
19. Koopen NR, Wolters H, Havinga R, Vonk RJ, Jansen PL, Muller M, et al. Impaired activity of the bile canalicular organic anion transporter (Mrp2/cmoat) is not the main cause of ethinylestradiol-induced cholestasis in the rat. Hepatology. 1998;27:537-545. (Pubitemid 28081071)
20. Ruiz ML, Villanueva SS, Luquita MG, Ikushiro S, Mottino AD, Catania VA. Beneficial effect of spironolactone administration on ethynylestradiol-induced cholestasis in the rat: involvement of up-regulation of multidrug resistance-associated protein 2. Drug Metab Dispos. 2007;35:2060-6. (Pubitemid 350005196)
21. Sanchez Pozzi EJ, Crocenzi FA, Pellegrino JM, Catania VA, Luquita MG, Roma MG, et al. Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. J Pharmacol Exp Ther. 2003;306:279-86. (Pubitemid 36734383)
22. Nathanson MH, Boyer JL. Mechanisms and regulation of bile secretion. Hepatology. 1991;14:551-66.
23. Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 2003;83:633-71. (Pubitemid 36378680)
24. Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, et al. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem. 1998;273:10046-50. (Pubitemid 28183107)
25. Rebbeor JF, Connolly GC, Ballatori N. Inhibition of Mrp2- and Ycf1p-mediated transport by reducing agents: evidence for GSH transport on rat Mrp2. Biochim Biophys Acta. 2002;1559:171-8. (Pubitemid 34164425)
26. Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ. Human bi-le salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem. 2001;276:28857-65.
27. Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem. 2002;277:2908-15. (Pubitemid 34953324)
28. Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell. 2000;6:517-26.
29. Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell. 2000;6:507-15.
30. Denson LA, Sturm E, Echevarria W, Zimmerman TL, Makishima M, Mangelsdorf DJ, et al. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology. 2001;121:140-7. (Pubitemid 32591524)
31. Zimmer V, Mullenbach R, Simon E, Bartz C, Matern S, Lammert F. Combined functional variants of hepatobiliary transporters and FXR aggravate intrahepatic cholestasis of pregnancy. Liver Int. 2009;29:1286-8.
32. Van Mil SW, Milona A, Dixon PH, Mullenbach R, Geenes VL, Chambers J, et al. Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy. Gastroenterology. 2007;133:507-16.
33. Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, et al. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol. 2006;290:G1124-30.
34. Aoyama N, Ohya T, Chandler K, Gresky S, Holzbach RT. Transcellular transport of organic anio-ns in the isolated perfused rat liver: the differential effects of monensin and colchicine. Hepatology. 1991;14:1-9.
35. Tachizawa H, Sano N, Takikawa H. Effects of colchicine on the maximum biliary excretion of cholephilic compounds in rats. J Gastroenterol Hepatol. 2004;19:1016-22. (Pubitemid 39237436)
36. Takikawa H, Sano N, Akimoto K, Ogasawara T, Yamanaka M. Effects of colchicine and phenothiazine on biliary excretion of organic anions in rats. J Gastroenterol Hepatol. 1998;13:427-32. (Pubitemid 28215954)