Chromosomal regions associated with prostate cancer risk localize to lamin B-deficient microdomains and exhibit reduced gene transcription

Journal of Pathology

Volumn 226, Issue 5, 2012, Pages 735-745

  Helfand, Brian T ^a   Wang, Yuanyuan ^a   Pfleghaar, Katrin ^a,b   Shimi, Takeshi ^a   Taimen, Pekka ^a,c   Shumaker, Dale K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Chromatin organization; Lamins; Nucleoskeleton; RNA polymerase II transcription

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; HISTONE; LAMININ BINDING PROTEIN; RNA POLYMERASE II;

ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CELL ELONGATION; CELL MOTILITY; CELL NUCLEUS INCLUSION BODY; CELL STRAIN LNCAP; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN STRUCTURE; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE ACTIVATION; GENETIC TRANSCRIPTION; GLEASON SCORE; HUMAN; HUMAN CELL; LAMIN B DEFICIENT MICRODOMAIN; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

BINDING SITES; CELL LINE, TUMOR; CELL MOVEMENT; CELL NUCLEUS SHAPE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMOSOMES, HUMAN; COMPARATIVE GENOMIC HYBRIDIZATION; DOWN-REGULATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LAMIN TYPE A; LAMIN TYPE B; LASER CAPTURE MICRODISSECTION; MALE; MEMBRANE MICRODOMAINS; MICROSCOPY, FLUORESCENCE; NEOPLASM GRADING; NUCLEAR ENVELOPE; PROSTATIC NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANDROGEN; RNA POLYMERASE II; TIME FACTORS; TISSUE ARRAY ANALYSIS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84862777747     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.3033     Document Type: Article

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