Rho-Kinase Inhibitor Attenuates Cholestasis-Induced CXC Chemokine Formation, Leukocyte Recruitment, and Hepatocellular Damage in the Liver

Journal of Surgical Research

Volumn 159, Issue 2, 2010, Pages 666-673

  Laschke, Matthias W ^a,b   Dold, Stefan ^a,b   Jeppsson, Bengt ^a   Schilling, Martin K ^b   Menger, Michael D ^b   Thorlacius, Henrik ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

bile duct ligation; cholestasis; CXC chemokines; intravital fluorescence microscopy; leukocytes; Rho kinase; Y 27632

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALANINE AMINOTRANSFERASE; ALPHA CHEMOKINE; ASPARTATE AMINOTRANSFERASE; PHOSPHATE BUFFERED SALINE; RHO KINASE INHIBITOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE DUCT LIGATION; CHOLESTASIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DOSE COMPARISON; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MOUSE; EXPERIMENTAL STUDY; FLUORESCENCE MICROSCOPY; INHIBITION KINETICS; LEUKOCYTE; LIVER CELL DAMAGE; LIVER PERFUSION; LIVER PROTECTION; LIVER SINUSOID; MALE; MOUSE; NONHUMAN; OBSTRUCTIVE CHOLESTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION; SHAM PROCEDURE; SIGNAL TRANSDUCTION;

ALANINE TRANSAMINASE; AMIDES; ANIMALS; ANTIHYPERTENSIVE AGENTS; ASPARTATE AMINOTRANSFERASES; CHEMOKINES, CXC; CHOLESTASIS; CHOLESTASIS, INTRAHEPATIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; LIVER; MALE; MICE; MICE, INBRED C57BL; PYRIDINES; RHO-ASSOCIATED KINASES;

EID: 77949485210     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2008.08.023     Document Type: Article

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