Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout

Amino Acids

Volumn 42, Issue 6, 2012, Pages 2461-2472

  Stellingwerff, Trent ^a   Anwander, Helen ^b   Egger, Andrea ^b   Buehler, Tania ^b   Kreis, Roland ^b   Decombaz, Jacques ^a   Boesch, Chris ^b  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

alanine; Carnosine; Dose response; Muscle; Synthesis; Washout

Indexed keywords

BETA ALANINE; CARNOSINE; CREATINE; PLACEBO;

ABNORMAL SENSATION; ADULT; ARTICLE; BLOOD CHEMISTRY; CLINICAL CHEMISTRY; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; DRUG SAFETY; FLUSHING; GASTROCNEMIUS MUSCLE; HUMAN; HUMAN EXPERIMENT; LOW DRUG DOSE; MALE; MOOD CHANGE; MUSCLE LEVEL; NORMAL HUMAN; PARESTHESIA; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TIBIALIS ANTERIOR MUSCLE; TREATMENT DURATION; UPREGULATION;

ADULT; BETA-ALANINE; CARNOSINE; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MUSCLE, SKELETAL; PLACEBOS;

EID: 84862770558     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-1054-4     Document Type: Article

References (40)

1. H Abe 2000 Role of histidine-related compounds as intracellular proton buffering constituents in vertebrate muscle Biochemistry (Mosc) 65 757 765 1:CAS:528:DC%2BD3cXlvFOlsb4%3D
2. C Albani G Blaser M Geyer G Schmutzer E Brähler H Bailer, et al. 2005 Überprüfung der Gütekriterien der deutschen Kurzform des Fragebogens "Profile of Mood States" (POMS) in einer repräsentativen Bevolkerungsstichprobe Psychother Psychiatr Med 55 324 330 10.1055/s-2004-834727
3. GG Artioli B Gualano A Smith J Stout AH Lancha Jr 2010 Role of beta-alanine supplementation on muscle carnosine and exercise performance Med Sci Sports Exerc 42 1162 1173 20479615 1:CAS:528:DC%2BC3cXmtFKlu78%3D
4. AM Asatoor JK Bandoh AF Lant MD Milne F Navab 1970 Intestinal absorption of carnosine and its constituent amino acids in man Gut 11 250 254 5423906 10.1136/gut.11.3.250 1:CAS:528:DyaE3cXktleitrk%3D
5. A Baguet H Reyngoudt A Pottier I Everaert S Callens E Achten, et al. 2009 Carnosine loading and washout in human skeletal muscles J Appl Physiol 106 837 842 19131472 10.1152/japplphysiol.91357.2008 1:CAS:528:DC%2BD1MXjvFWmtrg%3D
6. A Baguet J Bourgois L Vanhee E Achten W Derave 2010 Important role of muscle carnosine in rowing performance J Appl Physiol 109 1096 1101 20671038 10.1152/japplphysiol.00141.2010
7. A Baguet K Koppo A Pottier W Derave 2010 Beta-alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise Eur J Appl Physiol 108 495 503 19841932 10.1007/s00421-009-1225-0 1:CAS:528:DC%2BC3cXmsVGku7s%3D
8. A Bakardjiev K Bauer 1994 Transport of beta-alanine and biosynthesis of carnosine by skeletal muscle cells in primary culture Eur J Biochem 225 617 623 7957176 10.1111/j.1432-1033.1994.00617.x 1:CAS:528:DyaK2cXmt1Ojtb0%3D
9. EC Bate-Smith 1938 The buffering of muscle in rigor: protein, phosphate and carnosine J Physiol 92 336 343
10. MA Batrukova AM Rubtsov 1997 Histidine-containing dipeptides as endogenous regulators of the activity of sarcoplasmic reticulum Ca-release channels Biochim Biophys Acta 1324 142 150 9059507 10.1016/S0005-2736(96)00216-7 1:CAS:528:DyaK2sXpt1yhtQ%3D%3D
11. C Boesch R Kreis 2001 Dipolar coupling and ordering effects observed in magnetic resonance spectra of skeletal muscle NMR Biomed 14 140 148 11320539 10.1002/nbm.684 1:CAS:528:DC%2BD3MXjvVentL4%3D
12. AA Boldyrev A Koldobski E Kurella V Maltseva S Stvolinski 1993 Natural histidine-containing dipeptide carnosine as a potent hydrophilic antioxidant with membrane stabilizing function. A biomedical aspect Mol Chem Neuropathol 19 185 192 8363703 10.1007/BF03160178 1:CAS:528:DyaK3sXltlSktrw%3D
13. J Decombaz M Beaumont J Vuichoud F Bouisset M Enslen T Stellingwerff 2011 The effect of slow-release β-alanine on absorption kinetics and paresthesia (abstract) Med Sci Sports Exerc 43 S2224 10.1249/MSS. 0b013e318223522d
14. W Derave MS Ozdemir RC Harris A Pottier H Reyngoudt K Koppo, et al. 2007 β-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters J Appl Physiol 103 1736 1743 17690198 10.1152/japplphysiol.00397.2007 1:CAS:528:DC%2BD2sXhtlyrtrzK
15. W Derave I Everaert S Beeckman A Baguet 2010 Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training Sports Med 40 247 263 20199122 10.2165/11530310-000000000-00000
16. M Dunnett RC Harris 1995 Carnosine and taurine contents of different fibre types in the middle gluteal muscle of the thoroughbred horse Equine Vet J S18 214 217
17. I Everaert A Mooyaart A Baguet A Zutinic H Baelde E Achten, et al. 2011 Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans Amino Acids 40 1221 1229 20865290 10.1007/s00726-010-0749-2 1:CAS:528:DC%2BC3MXjsFGjur4%3D
18. L Flancbaum JC Fitzpatrick DN Brotman AM Marcoux E Kasziba H Fisher 1990 The presence and significance of carnosine in histamine-containing tissues of several mammalian species Agents Actions 31 190 196 2085137 10.1007/BF01997607 1:CAS:528:DyaK3cXmtVGhsbc%3D
19. RC Harris K Soderlund E Hultman 1992 Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation Clin Sci 8 367 374
20. RC Harris MJ Tallon M Dunnett L Boobis J Coakley HJ Kim, et al. 2006 The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis Amino Acids 30 279 289 16554972 10.1007/s00726-006-0299-9 1:CAS:528:DC%2BD28Xktlaksrk%3D
21. Harris RC, Jones GA, Wise JA (2008) The plasma concentration-time profile of beta-alanine using a controlled-release formulation (Carnosyn) (abstract). FASEB J 22:701.9
22. CA Hill RC Harris HJ Kim BD Harris C Sale LH Boobis, et al. 2007 Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity Amino Acids 32 225 233 16868650 10.1007/s00726-006-0364-4 1:CAS:528:DC%2BD2sXhtFyhtbo%3D
23. AR Hipkiss 2005 Glycation, ageing and carnosine: are carnivorous diets beneficial? Mech Ageing Dev 126 1034 1039 15955546 10.1016/j.mad.2005.05.002 1:CAS:528:DC%2BD2MXpvFeisbk%3D
24. J Hoffman N Ratamess J Kang G Mangine A Faigenbaum J Stout 2006 Effect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes Int J Sport Nutr Exerc Metab 16 430 446 17136944 1:CAS:528:DC%2BD2sXlvFylsbo%3D
25. E Hultman K Soderlund JA Timmons G Cederblad PL Greenhaff 1996 Muscle creatine loading in men J Appl Physiol 81 232 237 8828669 1:CAS:528: DyaK28XkvFemtL0%3D
26. IP Kendrick RC Harris HJ Kim CK Kim VH Dang TQ Lam, et al. 2008 The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition Amino Acids 34 547 554 18175046 10.1007/s00726-007-0008-3 1:CAS:528:DC%2BD1cXlsVOgsb0%3D
27. IP Kendrick HJ Kim RC Harris CK Kim VH Dang TQ Lamb, et al. 2009 The effect of 4 weeks beta-alanine supplementation and isokinetic training on carnosine concentrations in type I and II human skeletal muscle fibres Eur J Appl Physiol 106 131 138 19214556 10.1007/s00421-009-0998-5 1:CAS:528: DC%2BD1MXkvValtLk%3D
28. Kley RA, Tarnopolsky MA, Vorgerd M (2011) Creatine for treating muscle disorders. Cochrane Database Syst Rev 2:CD004760
29. A Naressi C Couturier JM Devos M Janssen C Mangeat R de Beer, et al. 2001 Java-based graphical user interface for the MRUI quantitation package Magma 12 141 152 11390270 10.1007/BF02668096 1:STN:280:DC%2BD3MzitVelsA%3D%3D
30. MS Ozdemir H Reyngoudt Y De Deene HS Sazak E Fieremans S Delputte, et al. 2007 Absolute quantification of carnosine in human calf muscle by proton magnetic resonance spectroscopy Phys Med Biol 52 6781 6794 18029975 10.1088/0031-9155/52/23/001 1:CAS:528:DC%2BD1cXhtVCjsrw%3D
31. YJ Park SL Volpe EA Decker 2005 Quantitation of carnosine in humans plasma after dietary consumption of beef J Agric Food Chem 53 4736 4739 15941308 10.1021/jf047934h 1:CAS:528:DC%2BD2MXjslKls7k%3D
32. WS Parkhouse DC McKenzie 1984 Possible contribution of skeletal muscle buffers to enhanced anaerobic performance: a brief review Med Sci Sports Exerc 16 328 338 6092820 1:CAS:528:DyaL2MXht12ht7c%3D
33. C Sale B Saunders RC Harris 2010 Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance Amino Acids 39 321 333 20091069 10.1007/s00726-009-0443-4 1:CAS:528:DC%2BC3cXotVaisL4%3D
34. Sale C, Saunders B, Hudson S, Wise JA, Harris RC, Sunderland CD (2011) Effect of beta-alanine plus sodium bicarbonate on high-intensity cycling capacity. Med Sci Sports Exerc. doi: 10.1249/MSS.0b013e3182188501
35. L Schroder P Bachert 2003 Evidence for a dipolar-coupled AM system in carnosine in human calf muscle from in vivo 1H NMR spectroscopy J Magn Reson 164 256 269 14511594 10.1016/S1090-7807(03)00205-2 1:CAS:528:DC%2BD3sXnsVKgtbg%3D
36. S Shacham 1983 A shortened version of the profile of mood states J Pers Assess 47 305 306 6886962 10.1207/s15327752jpa4703-14 1:STN:280: DyaL3s3ptl2qsg%3D%3D
37. Y Shen S Zhang L Fu W Hu Z Chen 2008 Carnosine attenuates mast cell degranulation and histamine release induced by oxygen-glucose deprivation Cell Biochem Funct 26 334 338 18064721 10.1002/cbf.1447 1:CAS:528: DC%2BD1cXlsF2ht7o%3D
38. Spielberger CD, Gorsuch RL, Lushene PR, Vagg PR, Jacobs AG (1983) Manual for the state-trait anxiety inventory (Form Y). Consulting Psychologists Press Inc., Palo Alto, CA, p 36
39. JR Stout JT Cramer M Mielke J O'Kroy DJ Torok RF Zoeller 2006 Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold J Strength Cond Res 20 928 931 17194255
40. RF Zoeller JR Stout JA O'Kroy DJ Torok M Mielke 2007 Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion Amino Acids 33 505 510 16953366 10.1007/s00726-006-0399-6 1:CAS:528:DC%2BD2sXpvVahu74%3D