A novel μ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

British Journal of Pharmacology

Volumn 166, Issue 5, 2012, Pages 1654-1668

  Favreau, Philippe ^a,b   Benoit, Evelyne ^b   Hocking, Henry G ^c   Carlier, Ludovic ^c,i   D'Hoedt, Dieter ^d   Leipold, Enrico ^e   Markgraf, René ^e   Schlumberger, Sébastien ^b   Córdova, Marco A ^f   Gaertner, Hubert ^a,g   Paolini Bertrand, Marianne ^g   Hartley, Oliver ^g   Tytgat, Jan ^h   Heinemann, Stefan H ^e   Bertrand, Daniel ^d,j   Boelens, Rolf ^c   Stöcklin, Reto ^a   Molgó, Jordi ^b  

^a ATHERIS LABORATORIES   (Switzerland)

^b CNRS   (France)

^c UTRECHT UNIVERSITY   (Netherlands)

^d Department of Neuroscience ^*  (Switzerland)

^e JENA UNIVERSITY HOSPITAL   (Germany)

^f UNIVERSITY OF CHILE   (Chile)

^g UNIVERSITY OF GENEVA   (Switzerland)

^h Laboratorium voor Toxicologie   (Belgium)

ⁱ SORBONNE UNIVERSITÉ   (France)

^j HiQScreen   (Switzerland)

more..

Author keywords

conotoxin; cone snail venom; myorelaxant; nicotinic acetylcholine receptor; NMR structure; twitch tension; voltage gated sodium channel

Indexed keywords

ALPHA CONOTOXIN; BUNGAROTOXIN RECEPTOR; CONOTOXIN; MU CONOTOXIN CNIIIC; MU CONOTOXIN PIIIA; MU CONOTOXIN SIIIA; MU CONOTOXIN SMIIIA; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA2; NICOTINIC RECEPTOR ALPHA4BETA2; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.4; SODIUM CHANNEL NAV1.8; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; EXTENSOR DIGITORUM LONGUS MUSCLE; FEMALE; HEMIDIAPHRAGM; HUMAN; HUMAN CELL; MALE; MOUSE; MUSCLE ACTION POTENTIAL; MUSCLE RELAXATION; MUSCLE TWITCH; NONHUMAN; OLFACTORY NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BLOCKING; SCIATIC NERVE; SKELETAL MUSCLE; STRUCTURAL HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CONOTOXINS; CONUS SNAIL; ESOCIDAE; FEMALE; HEK293 CELLS; HUMANS; MALE; MICE; MOLECULAR SEQUENCE DATA; MUSCLE CONTRACTION; MUSCLE, SKELETAL; NICOTINIC ANTAGONISTS; OLFACTORY NERVE; OOCYTES; PEPTIDES; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC; SCIATIC NERVE; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; XENOPUS LAEVIS;

EID: 84862746833     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01837.x     Document Type: Article

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