Structural Basis for Tetrodotoxin-resistant Sodium Channel Binding by μ-Conotoxin SmIIIA

Journal of Biological Chemistry

Volumn 278, Issue 47, 2003, Pages 46805-46813

  Keizer, David W ^a   West, Peter J ^b,c   Lee, Erinna F ^a   Yoshikami, Doju ^c   Olivera, Baldomero M ^c   Bulaj, Grzegorz ^c,d   Norton, Raymond S ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d NMR Laboratory ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL BONDS; CONFORMATIONS; MOLECULAR STRUCTURE; SODIUM; TOXIC MATERIALS;

SODIUM CHANNELS;

BIOCHEMISTRY;

ARGININE; CONOTOXIN; HYDROXYPROLINE; LYSINE; MU CONOTOXIN SMIIIA; PEPTIDE; SODIUM CHANNEL; TETRODOTOXIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ADRENERGIC NERVE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHEMICAL BOND; CIS ISOMER; CONFORMATION; CONTROLLED STUDY; CONUS GEOGRAPHUS; FROG; NERVE FIBER C; NERVE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; SNAIL; STRUCTURE ANALYSIS; TOXIN STRUCTURE; TRANS ISOMER;

ACTION POTENTIALS; AMINO ACID SEQUENCE; ANIMALS; AXONS; CONOTOXINS; MOLLUSK VENOMS; NEUROPEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; RANIDAE; RECOMBINANT FUSION PROTEINS; SNAILS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; ANURA; CONUS GEOGRAPHUS; CONUS STERCUSMUSCARUM; GASTROPODA; VERTEBRATA;

EID: 0345306633     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309222200     Document Type: Article

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