The role of CD4+ and CD8+ T cells in demyelinating disease following Theiler's virus infection: A model for multiple sclerosis

Journal of NeuroVirology

Volumn 3, Issue SUPPL. 1, 1997, Pages

  Rodriguez, M ^a   Rivera Quinones, Cynthia ^a   Murray, Paul D ^a   Njenga, M Kariuki ^a   Wettstein, Peter J ^a   Mak, Tak ^b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Multiple sclerosis; Myelin; Picornavirus; Theiler's murine encephalomyelitis virus

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CENTRAL NERVOUS SYSTEM INFECTION; CONFERENCE PAPER; DEMYELINATING DISEASE; MOUSE; MULTIPLE SCLEROSIS; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PICORNAVIRUS; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; H-2 ANTIGENS; HUMANS; MICE; MICE, INBRED BALB C; MICE, SCID; MULTIPLE SCLEROSIS; MYELIN SHEATH; NEURONS; POLIOMYELITIS; RNA, VIRAL; SPINAL CORD; THEILOVIRUS;

EID: 0030943998     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (6)

1. Kariuki Njenga M, Pavelko KD, Baisch J, et al (1996). Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice. J Virol 70: 1729-1737.
2. Mak TW, Rahemtulla A, Schilham M, Koh DR, Fung-Leung WP (1992). Generation of mutant mice lacking surface expression of CD4 or CD8 gene targeting. [Review]. Adv Exp Med Biol 323: 73-77.
3. Rodriguez M, Pease LP and David CD (1986). Immune-mediated injury of virus-infected oligodendrocytes: A model of multiple sclerosis. Immunol Today 7: 359-363.
4. Rodriguez M, Oleszak E, Leibowitz J (1987). Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus. Crit Rev Immunol 7: 325-365.
5. Rodriguez M, Dunkel AJ, Thiemann RL, Leibowitz J, Zijlstra M, Jaenisch R (1993). Abrogation of resistance to Theiler's virus-induced demyelination in H-2b mice deficient in beta 2-microglobulin. J Immunol 151: 266-276.
6. Rodriguez M, Pavelko KD, Njenga MK, Logan WC, Wettstein PJ (1996). The balance between persistent virus infection and immune cells determines demyelination. J Immunol 157: 5699-5708.