Carnosine and its (S)-Trolox™ derivative protect animals against oxidative stress

Amino Acids

Volumn 43, Issue 1, 2012, Pages 165-170

  Stvolinsky, S ^a   Toropova, K ^b   Gordeeva, M ^b   Kazey, V ^c   Sato, T ^d   Meguro, K ^d   Boldyrev, A ^a,b  

^a RESEARCH CENTER OF NEUROLOGY   (Russian Federation)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

^c Chemical Diversity Research Institute   (Russian Federation)

^d Technology Department / Yonezawa Hamari Chemicals Ltd 2 4300 18   (Japan)

Author keywords

Acute hypobaric hypoxia; Antioxidant defense; Brain; Carnosine; Oxidative stress; Trolox

Indexed keywords

6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMAN 2 CARBONYL BETA ALANYLHISTIDINE; CARNOSINE; CARNOSINE DERIVATIVE; TROLOX C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN HYPOXIA; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG STRUCTURE; FEMALE; GERONTOLOGY; LIFESPAN; MALE; NEUROLOGY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SEX DIFFERENCE;

ANIMALS; ANOXIA; ANTIOXIDANTS; BRAIN; CARNOSINE; CHROMANS; DROSOPHILA MELANOGASTER; FEMALE; HISTIDINE; MALE; MAZE LEARNING; OXIDATIVE STRESS; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 84862731041     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-012-1256-4     Document Type: Article

References (32)

1. G Aldini M Orioli G Rossoni F Savi P Braidotti G Vistoli KJ Yeum G Negrisoli M Carini 2011 The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats J Cell Mol Med 15 6 1339 1354 20518851 10.1111/j.1582-4934.2010.01101.x 1:CAS:528:DC%2BC3MXnvFelsrk%3D
2. O Aruoma M Laughton B Halliwell 1989 Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo? Biochem J 264 863 869 2559719 1:CAS:528:DyaK3cXltlyq (Pubitemid 20023461)
3. A Biegel I Knütter B Hartrodt S Gebauer S Theis P Luckner G Kottra M Rastetter K Zebisch I Thondorf H Daniel K Neubert M Brandsch 2006 The renal type H+/peptide symporter PEPT2: structure-affinity relationships Amino Acids 31 2 137 156 16868651 10.1007/s00726-006-0331-0 1:CAS:528:DC%2BD28XotVynurs%3D (Pubitemid 44222575)
4. AA Boldyrev 1993 Does carnosine possess direct antioxidant activity? Int J Biochem 25 1101 1107 8405650 10.1016/0020-711X(93)90587-5 1:CAS:528: DyaK3sXlvFGjs7o%3D (Pubitemid 23236246)
5. Boldyrev AA (2003) Significance of reactive oxygen species for neuronal function. In: Tomasi A et al (eds) Free radicals, NO, and Inflammation: molecular, biochemical and clinical aspects. IOS Press, The Netherlands, pp 153-169
6. A Boldyrev 2005 Protection of proteins from oxidative stress: a new illusion or a novel strategy? Ann N Y Acad Sci 1057 193 205 16399895 10.1196/annals.1356.013 1:CAS:528:DC%2BD28XhvFGntbo%3D (Pubitemid 43211635)
7. Boldyrev A (2006) Carnosine and protection of cells and tissues against oxidative stress, NovaPubl., NY
8. AA Boldyrev AM Dupin AYa Bunin MA Babizhaev SE Severin 1987 The antioxidative properties of carnosine, a natural histidine containing dipeptide Biochem Int 15 1105 1113 3326603 1:CAS:528:DyaL1cXovVSgsQ%3D%3D (Pubitemid 18014870)
9. AA Boldyrev SL Stvolinsky OV Tyulina VB Koshelev N Hori D Carpenter 1997 Biochemical and physiological evidence that carnosine is an endogenous neuroprotector against free radicals Cell Mol Neurobiol 17 2 259 271 9140702 10.1023/A:1026374114314 1:CAS:528:DyaK2sXjtleqtL4%3D (Pubitemid 27190685)
10. A Boldyrev R Song D Lawrence DO Carpenter 1999 Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species Neuroscience 94 571 577 10579217 10.1016/S0306-4522(99)00273-0 1:CAS:528:DyaK1MXmt1entrs%3D (Pubitemid 29436082)
11. A Boldyrev S Stvolinsky T Fedorova Z Suslina 2010 Carnosine as a natural antioxidant and geroprotector: from molecular mechanisms to clinical trials Rejuv Res 13 2-3 156 158 10.1089/rej.2009.0923 1:CAS:528:DC%2BC3cXlvFyksLo%3D
12. D Dobrota T Fedorova M Stepanova E Babusikova D Statelova Z Tatarkova S Stvolinsky A Boldyrev 2010 Oxidative stress, induced in rat brain by a combination of 3-nitropropionic acid and global ischemia J Clin Exp Med 3 144 152 1:CAS:528:DC%2BC3cXmslyjs7w%3D
13. LA Feldman ML Shapiro J Nalbantoglu 2010 A novel, rapidly acquired and persistent spatial memory task that induces immediate early gene expression Behav Brain Funct 6 35 46 20594357 10.1186/1744-9081-6-35
14. S Gallant M Kukley S Stvolinsky E Bulygina A Boldyrev 2000 Effect of carnosine on rats under experimental brain ischemia Tohoku J Exp Med 191 85 99 10946918 10.1620/tjem.191.85 1:CAS:528:DC%2BD3cXlvFWgtbc%3D
15. S Gupta SS Sharma 2006 Neuroprotective effects of Trolox™ in global cerebral ischemia in gerbils Biol Pharm Bull 29 957 961 16651726 10.1248/bpb.29.957 1:CAS:528:DC%2BD28Xmt1eht7c%3D
16. A Hipkiss 2009 Carnosine and its possible roles in nutrition and health Adv Food Nutr Res 57 87 154 19595386 10.1016/S1043-4526(09)57003-9 1:CAS:528:DC%2BC3cXmt1Ohuw%3D%3D
17. KG Iliadi NN Iliadi GL Boulianne 2009 Regulation of Drosophila life-span: effect of genetic background, sex, mating and social status Exp Gerontol 44 546 553 19481597 10.1016/j.exger.2009.05.008
18. JH Kang 2010 Protective effects of carnosine and homocarnosine on ferritin and hydrogen peroxide-mediated DNA damage BMB Rep 43 10 683 687 21034531 10.5483/BMBRep.2010.43.10.683 1:CAS:528:DC%2BC3cXhsVKrt7bN
19. R Kohen Y Yamamoto K Cundy BN Ames 1988 Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain Proc Natl Acad Sci USA 85 3175 3179 3362866 10.1073/pnas.85.9.3175 1:CAS:528: DyaL1cXitF2ns7w%3D
20. E Koren R Kohen I Ginsburg 2010 Polyphenols enhance total oxidant-scavenging capacities of human blood by binding to red blood cells Exp Biol Med 235 689 699 10.1258/ebm.2010.009370 1:CAS:528:DC%2BC3cXpsVOjsbs%3D
21. VA Kosolapov AA Spasov EV Tibirjkov 2009 Antioxidant and membrane protector properties of Trolox™ Exptl Clin Pharmacol 2 47 50
22. T Leinsoo H Abe A Boldyrev 2006 Carnosine and related compounds protect double-helices DNA against oxidative injury J Evol Biochem Physiol 42 453 456 10.1134/S0022093006050061 1:STN:280:DC%2BD28nltlCksw%3D%3D (Pubitemid 44951116)
23. FA Lints M Bourgois A Delalieux J Stoll CV Lints 1983 Does the female life span exceed that of the male? A study in Drosophila melanogaster Gerontology 29 336 352 6413302 10.1159/000213136 1:STN:280: DyaL2c%2FgsF2isw%3D%3D (Pubitemid 13039186)
24. DJ Miller A O'Dowd 2000 Vascular smooth muscle actions of carnosine as its zinc complex are mediated by histamine H(1) and H(2) receptors Biochemistry (Mosc) 65 7 798 806 1:CAS:528:DC%2BD3cXlvFOlsbg%3D
25. R Morris 1984 Developments of a water-maze procedure for studying spatial learning in the rat J Neurosci Methods 11 47 60 6471907 10.1016/0165-0270(84) 90007-4 1:STN:280:DyaL2c3ptl2lug%3D%3D (Pubitemid 14088970)
26. K Schlesier M Harwat V Bohm R Bitsch 2002 Assessment of antioxidant activity by using different in vitro methods Free Rad Res 36 177 187 10.1080/10715760290006411 1:CAS:528:DC%2BD38XotFGmsrw%3D
27. SS Sharma RK Kaundal 2007 Neuroprotective effects of 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid (Trolox™), an antioxidant in middle cerebral artery occlusion induced focal cerebral ischemia in rats Neurol Res 29 3 304 309 17509231 10.1179/016164107X158983 1:CAS:528:DC%2BD2sXntFOlsr0%3D (Pubitemid 46802369)
28. SL Stvolinsky ML Kukley D Dobrota M Matejovicova I Tkac AA Boldyrev 1999 Carnosine: an endogeneous neuroprotector in ischemic brain Cell Molec Neurobiol 19 45 56 10079964 10.1023/A:1006960407008 1:CAS:528:DyaK1MXhsFSit7c%3D (Pubitemid 29102093)
29. SL Stvolinsky ER Bulygina TN Fedorova K Meguro T Sato OV Tyulina H Abe AA Boldyrev 2010 Biological activity of novel synthetic derivatives of carnosine Cell Mol Neurobiol 30 3 395 404 19798566 10.1007/s10571-009-9462-7 1:CAS:528:DC%2BC3cXksVekt7w%3D
30. S Stvolinsky M Antipin K Meguro T Sato H Abe A Boldyrev 2010 Effect of carnosine and its Trolox™-modified derivatives on lifespan of Drosophila melanogaster Rejuv Res 13 4 453 457 10.1089/rej.2009.1010 1:CAS:528: DC%2BC3cXhtVKitLzF
31. M Tanida A Niijima Y Fukuda H Sawai N Tsuruoka J Shen S Yamada Y Kiso K Nagai 2005 Dose-dependent effects of l-carnosine on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats Am J Physiol Regul Integr Comp Physiol 288 2 R447 R455 15498968 10.1152/ajpregu.00275.2004 1:CAS:528: DC%2BD2MXhsFelsbs%3D (Pubitemid 40129612)
32. AO Yuneva GG Kramarenko TV Vetreshchak S Gallant AA Boldyrev 2010 Effect of carnosine on Drosophila melanogaster life span Bull Exp Biol Med 133 6 559 661 10.1023/A:1020273506970