Protective effects of carnosine and homocarnosine on ferritin and hydrogen peroxide-mediated DNA damage

BMB Reports

Volumn 43, Issue 10, 2010, Pages 683-687

  Kang, Jung Hoon ^a  

^a Chongju University   (South Korea)

Author keywords

Carnosine; DNA; Ferritin; Hydroxyl radical; Mutation

Indexed keywords

ANTIOXIDANT; CARNOSINE; DRUG DERIVATIVE; FERRITIN; HOMOCARNOSINE; HYDROGEN PEROXIDE; HYDROXYL RADICAL;

ARTICLE; CHEMISTRY; DNA DAMAGE; DRUG ANTAGONISM; DRUG EFFECT; EVALUATION; IN VITRO STUDY; LACTOSE OPERON; METABOLISM; MUTAGEN TESTING; MUTAGENESIS; OXIDATION REDUCTION REACTION; PLASMID;

ANTIOXIDANTS; CARNOSINE; DNA DAMAGE; FERRITINS; HYDROGEN PEROXIDE; HYDROXYL RADICAL; LAC OPERON; MUTAGENESIS; MUTAGENICITY TESTS; OXIDATION-REDUCTION; PLASMIDS;

EID: 78649479398     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.3858/BMBRep.2010.43.10.683     Document Type: Article

References (33)

1. Knovich, M. A., Storey, J. A., Coffman, L. G., Torti, S. V. and Torti, F. M. (2009) Ferritin for the clinician. Blood Rev. 23, 95-104.
2. Monterio, H., Ville, G. and Winterbourn, C. (1989) Release of iron from ferritin by semiquinone, anthracycline, bipyridyl, and nitroaromatic radicals. Free Radic. Biol. Med. 6, 587-591.
3. Lapenna, D., de Gioia, S., Mezzetti, A., Ciofani, G., Consoli, A., Marzio, L. and Cuccurullo, F. (1995) Cigarette smoke, ferritin, and lipid peroxidation. Am. J. Respir. Crit. Care Med. 151, 431-435.
4. Linert, W., Herlinger, E., Jameson, R. F., Kienzl, E., Jellinger, K. and Youdim, M. B. (1996) Dopamine, 6-hydroxydopamine, iron, and dioxygen-their mutual interactions and possible implication in the development of Parkinson's disease. Biochim. Biophys. Acta. 1316, 160-168.
5. Double, K. L., Maywald, M., Schmittle, M., Riederer, P. and Gerlach, M. (1998) In vitro studies of ferritin iron release and neurotoxicity. J. Neurochem. 70, 2492-2499.
6. Monterio, H. and Winterbourn, C. (1988) The superoxide-dependent transfer of iron from ferritin to transferrin and lactoferrin. Biochem. J. 256, 923-928.
7. Boyer, R., Grabill, T. and Petrovich, R. (1988) Reductive release of ferritin iron: a kinetic assay. Anal. Biochem. 174, 17-22.
8. Halliwell, B. and Gutteridge, J. M. (1985) The importance of free radicals and catalytic metal ions in human diseases. Mol. Aspects Med. 8, 89-193.
9. Gotz, E., Kunig, G., Riderer, P. and Youdim, M. B. (1994) Oxidative stress: free radical production in neural degeneration. Pharmacol. Ther. 63, 37-122.
10. 2 in vitro. Brain Res. 671, 181-186.
11. Gius, D. and Spitt, D. R. (2006) Redox signaling in cancer biology. Antioxid. Redox. Signal. 8, 1249-1252.
12. Behl, C., Davis, J. B., Lesley, R. and Schubert, D. (1994) Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77. 817-827.
13. Hipkiss, A. R. (1998) Carnosine, a protective, anti-ageing peptide. Int. J. Biochem. Cell Biol. 30, 863-868.
14. Alhamdani, M. S., Al-Kassir, A. H., Abbas, F. K., Jaleel, N. A. and Al-Taee, M. F. (2007) Antiglycation and antioxidant effect of carnosine against glucose degradation products in peritoneal mesothelial cells. Nephron. Clin. Pract. 107, c26-34.
15. Decker, E. A., Livisay, S. A. and Zhou, S. (2000) A re-evaluation of the antioxidant activity of purified carnosine. Biochemistry (Mosc) 65, 766-770.
16. Boldyrev, A., Bulygina, E., Leinsoo, T., Petrushanko, I., Tsubone, S. and Abe, H. (2004) Protection of neuronal cells aginst reactive oxygen species by carnosine and related compounds. Comp. Biochem. Physiol. 137, 81-88.
17. Fu, Q., Dai, H., Hu, W., Fan, Y., Shenn, Y., Zhang, W. and Chen, Z. (2008) Carnosine protects against Abeta41-induced neurotoxicity in differentiated rat PC12 cells. Cell Mol. Neurobiol. 28, 307-316
18. 2 as oxidants. Biophys. Chem. 111, 173-181
19. Zastawny, T. H., Altman, S. A., Randers-Eichhorn, L., Madurawe, R., Lumpkin, J. A., Dizdaroglu, M. and Rao, G. (1995) DNA base modifications and membrane damage in cultured mammalian cells treated with iron ions. Free Radic. Biol. Med. 18, 1013-1022.
20. Helbock, H. J., Beckman, K. B. and Ames, B. N. (1999) 8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage. Methods Enzymol. 300, 156-166.
21. Boldyrev, A. A., Dupin, A. M., Pindel, E. V. and Severin, S. E. (1988) Antioxidative properties of histidine-containing dipeptides from skeletal muscles of vertebrates. Comp. Biochem. Physiol. 89, 245-250.
22. Auroma, O. I., Laughton, M. J. and Halliwell, B. (1989) Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo? Biochem. J. 264, 863-869.
23. Brown, C. E. (1981) Interactions among carnosine, anserine, ophidine and copper in biochemical adaptation. J. Theor. Biol. 88, 245-256.
24. Decker, E. A., Crum, A. D. and Calvert, J. T. (1992) Differences in the Antioxidant mechanism of carnosine in the presence of copper and iron. J. Agric. Food Chem. 40, 756-759.
25. Aldini, G., Carini, M., Beretta, G., Bradamante, S. and Facino, R. M. (2002) Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction. Biochem. Biophys. Res. Commun. 298, 699-706.
26. Halliwell, B. and Gutteridge, J. M. (1981) Formation of thiobarbituric-acid-reactive substance from deoxyribose in the presence of iron salts: the role of superoxide and hydroxyl radicals. FEBS Lett. 128, 347-352.
27. Boveries, A., Oshino, N. and Chance, B. (1972) The cellular production of hydrogen peroxide. Biochem. J. 128, 617-630.
28. Imlay, J. A. and Fridovich, I. (1991) Assay of metabolic superoxide production in Escherichia coli. J. Biol. Chem. 266, 6957-6965.
29. Turrens, J. F., Beoni, M., Brilla, J., Chavez, U. B. and McCord, J. M., (1991) Mitochondrial generation of oxygen radicals during reoxygenation of ischemic tissues. Free. Radic. Res. Comms. 12-13, 681-689.
30. D'Agostino, D. P., Olson, J. E. and Dean, J. B. (2009) Acute hyperoxia increases lipid peroxidation and induces plasma membrane blebbing in human U87 glioblastoma cells. Neuroscience 159, 1011-1022.
31. McBride, T. J., Preston, B. D. and Loeb, L. A. (1991) Mutagenic spectrum resulting from DNA damage by oxygen radicals. Biochemistry 30, 207-213.
32. Kohen, R., Yamamoto, Y., Cundy, K. C. and Ames B. N. (1988) Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc. Natl. Acad. Sci. U.S.A. 85, 3175-3179.
33. Chan, W. K. M., Decker, E. A., Lee, J. B. and Butterfield, D. A. (1994) EPR-spin trapping studies of the hydroxyl radical scavenging activity of carnosine and related dipeptides. J. Agric. Food Chem. 42, 1407-1410.