Carnosine and related compounds protect the double-chain DNA from oxidative damages

Journal of Evolutionary Biochemistry and Physiology

Volumn 42, Issue 5, 2006, Pages 570-574

  Leinsoo, T A ^a   Abe, H ^b   Boldyrev, A A ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Anserine; Carnosine; DNA; Histidine; Homocarnosine; Hydroxyl radical; Ophidine

Indexed keywords

ANIMALIA; VERTEBRATA;

EID: 33845653046     PISSN: 00220930     EISSN: None     Source Type: Journal    
DOI: 10.1134/S0022093006050061     Document Type: Article

References (14)

1. Gille, J.J., Pasman, P., and van Berkel, C.G., Effect of Antioxidants on Hyperoxia-Induced Chromosomal Breakage in Chinese Hamster Ovary Cells: Protection by Carnosine, Mutagenesis, 1991, vol. 6, pp. 313-318.
2. Chikira, M. and Murakami, Y., Stereo-Specific Binding of Dinuclear Copper (II) Complex of L-Carnosine with DNA, Chemistry Lett., 1991, pp. 189-190.
3. Hyland, P., Duggan, O., Hipkiss, A., Barnett, C., and Barnett, Y., The Effect of Carnosine on Oxidative DNA Damage Levels and in vitro Lifespan in Human Peripheral Blood Derived CD4+T Cell Clones, Mech. Ageing Dev., 2000, vol. 121, pp. 203-215.
4. Boldyrev, A.A., Leinsoo, T.A., and Abe, H., Methylation of Neuropeptide Carnosine Modifies Its Protecting but not Antioxidant Properties, Abstr. of the XXXIII Ann. Meeting Soc. Neurosci. Washington (DC), USA, 2002, No. 671.7.
5. Sambrook, J., Fritsch, E.F., and Maniatis, T., Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor, 1989.
6. Boldyrev, A., Abe, H., Stvolinsky, S., and Tyulina, O., Effect of Carnosine and Related Compounds on Generation of Free Oxygen Species: A Comparative Study, Comp. Biochem. Physiol., 1995, vol. 112B, pp. 481-485.
7. Okuma, E. and Abe, H., Major Buffering Constituents in Animal Muscles, Comp. Biochem. Physiol., 1992, vol. 102A, pp. 37-41.
8. Boldyrev, A. and Severin, S., The Histidine-Containing Dipeptides, Carnosine and Anserine: Distribution, Properties and Biological Significance, Adv. Enzyme Regul., 1990, vol. 30, pp. 175-193.
9. Boldyrev, A.A., Karnozin (Carnosine), Moscow, 1998.
10. Rubtsov, A., Schara, M., Shentyrc, M., and Boldyrev, A., Hydroxyl Radical Scavenging Activity of Carnosine: A Spin-Trapping Study, Acta Pharm. Yugosl., 1991, vol. 41, pp. 401-407.
11. Pavlov, A., Repina, A., Dupin, A., Boldyrev, A., and Yaropolov, A., The Mechanism of Interaction of Carnosine with Superoxide Radicals in Water Solutions, Biochim. Biophys. Acta, 1993, vol. 1157, pp. 304-312.
12. Lavery, R. and Pullman, B., The Molecular Electrostatic Potential, Steric Accessibility and Hydration of Dickerson's B-DNA Dodecamer d(CpGpCpGpApApTpTpCpGpCpG), Nucl. Acids Res., 1981, vol. 9, pp. 3765-3777.
13. Petushkova, E.V., Formation of Complexes between Carnosine and ATP, Dokl. Akad. Nauk SSSR, 1971, vol. 199, pp. 715-718.
14. Severin, S.E., Bushuev, V.N., Shnol', S.E., Vishnevskaya, V.I., and Golovanov, I.B., Study of Complexes of Carnosine with Nucleotides by the Method of High Performance Nuclear Magnetic Resonance, Biokhimiya, 1976, vol. 41, pp. 197-201.