-
1
-
-
33751184394
-
A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer
-
doi:10.4161/cbt.5.7.2874
-
Argiris A, Cohen E, Karrison T, Esparaz B, Mauer A, Ansari R, Wong S, Lu Y, Pins M, Dancey J et al. 2006 A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer. Cancer Biology &Therapy 5 766-770. (doi:10.4161/cbt.5.7.2874)
-
(2006)
Cancer Biology &Therapy
, vol.5
, pp. 766-770
-
-
Argiris, A.1
Cohen, E.2
Karrison, T.3
Esparaz, B.4
Mauer, A.5
Ansari, R.6
Wong, S.7
Lu, Y.8
Pins, M.9
Dancey, J.10
-
2
-
-
81755172138
-
Randomized placebo-controlled phase II trial of perifosine plus capecitabine as second- or third-line therapy in patients with metastatic colorectal cancer
-
doi:10.1200/JCO.2011.36.1980
-
Bendell JC, Nemunaitis J, Vukelja SJ, Hagenstad C, Campos LT, Hermann RC, Sportelli P, Gardner L & Richards DA 2011 Randomized placebo-controlled phase II trial of perifosine plus capecitabine as second- or third-line therapy in patients with metastatic colorectal cancer. Journal of Clinical Oncology 29 4394-4400. (doi:10.1200/JCO.2011.36.1980)
-
(2011)
Journal of Clinical Oncology
, vol.29
, pp. 4394-4400
-
-
Bendell, J.C.1
Nemunaitis, J.2
Vukelja, S.J.3
Hagenstad, C.4
Campos, L.T.5
Hermann, R.C.6
Sportelli, P.7
Gardner, L.8
Richards, D.A.9
-
3
-
-
51349164790
-
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
-
doi:10.1172/JCI34739
-
Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC et al. 2008 Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. Journal of Clinical Investigation 118 3065-3074. (doi:10.1172/JCI34739)
-
(2008)
Journal of Clinical Investigation
, vol.118
, pp. 3065-3074
-
-
Carracedo, A.1
Ma, L.2
Teruya-Feldstein, J.3
Rojo, F.4
Salmena, L.5
Alimonti, A.6
Egia, A.7
Sasaki, A.T.8
Thomas, G.9
Kozma, S.C.10
-
4
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
-
doi:10.1126/science.292.5522.1728
-
Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB III, Kaestner KH, Bartolomei MS, Shulman GI &Birnbaum MJ 2001a Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292 1728-1731. (doi:10.1126/science.292.5522.1728)
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw III, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
5
-
-
0035914388
-
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
doi:10.1074/jbc.C100462200
-
Cho H, Thorvaldsen JL, Chu Q, Feng F & Birnbaum MJ 2001b Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. Journal of Biological Chemistry 276 38349-38352. (doi:10.1074/jbc.C100462200)
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
6
-
-
67449136114
-
Akt1 and Akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression
-
doi:10.1158/0008-5472.CAN-08-4287
-
Dillon RL, Marcotte R, Hennessy BT, Woodgett JR, Mills GB & Muller WJ 2009 Akt1 and Akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Cancer Research 69 5057-5064. (doi:10.1158/0008- 5472.CAN-08-4287)
-
(2009)
Cancer Research
, vol.69
, pp. 5057-5064
-
-
Dillon, R.L.1
Marcotte, R.2
Hennessy, B.T.3
Woodgett, J.R.4
Mills, G.B.5
Muller, W.J.6
-
7
-
-
20044382806
-
Role for Akt3/protein kinase Bgamma in attainment of normal brain size
-
doi:10.1128/MCB.25.5.1869-1878.2005
-
Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS, Lee VM, Szabolcs M, de Jong R, Oltersdorf T et al. 2005 Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Molecular and Cellular Biology 25 1869-1878. (doi:10.1128/MCB.25.5.1869-1878.2005)
-
(2005)
Molecular and Cellular Biology
, vol.25
, pp. 1869-1878
-
-
Easton, R.M.1
Cho, H.2
Roovers, K.3
Shineman, D.W.4
Mizrahi, M.5
Forman, M.S.6
Lee, V.M.7
Szabolcs, M.8
De Jong, R.9
Oltersdorf, T.10
-
8
-
-
31544448600
-
Phase II study of perifosine in previously untreated patients with metastatic melanoma
-
doi:10.1007/s10637-005-1157-4
-
Ernst DS, Eisenhauer E, Wainman N, Davis M, Lohmann R, Baetz T, Belanger K & Smylie M 2005 Phase II study of perifosine in previously untreated patients with metastatic melanoma. Investigational New Drugs 23 569-575. (doi:10.1007/s10637-005-1157-4)
-
(2005)
Investigational New Drugs
, vol.23
, pp. 569-575
-
-
Ernst, D.S.1
Eisenhauer, E.2
Wainman, N.3
Davis, M.4
Lohmann, R.5
Baetz, T.6
Belanger, K.7
Smylie, M.8
-
9
-
-
76049121742
-
Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia
-
doi:10.1158/1078-0432.CCR-09-1837
-
Ghobrial IM, Roccaro A, Hong F, Weller E, Rubin N, Leduc R, Rourke M, Chuma S, Sacco A, Jia X et al. 2010 Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia. Clinical Cancer Research 16 1033-1041. (doi:10.1158/1078-0432.CCR-09-1837)
-
(2010)
Clinical Cancer Research
, vol.16
, pp. 1033-1041
-
-
Ghobrial, I.M.1
Roccaro, A.2
Hong, F.3
Weller, E.4
Rubin, N.5
Leduc, R.6
Rourke, M.7
Chuma, S.8
Sacco, A.9
Jia, X.10
-
10
-
-
60349088457
-
Perifosine: Update on a novel Akt inhibitor
-
doi:10.1007/s11912-009-0016-4
-
Gills JJ & Dennis PA 2009 Perifosine: update on a novel Akt inhibitor. Current Oncology Reports 11 102-110. (doi:10.1007/s11912-009-0016-4)
-
(2009)
Current Oncology Reports
, vol.11
, pp. 102-110
-
-
Gills, J.J.1
Dennis, P.A.2
-
11
-
-
33646577479
-
Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
-
doi:10.1182/blood-2005-08-3434
-
Hideshima T, Catley L, Yasui H, Ishitsuka K, Raje N, Mitsiades C, Podar K, Munshi NC, Chauhan D, Richardson PG et al. 2006 Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood 107 4053-4062. (doi:10.1182/blood-2005-08-3434)
-
(2006)
Blood
, vol.107
, pp. 4053-4062
-
-
Hideshima, T.1
Catley, L.2
Yasui, H.3
Ishitsuka, K.4
Raje, N.5
Mitsiades, C.6
Podar, K.7
Munshi, N.C.8
Chauhan, D.9
Richardson, P.G.10
-
12
-
-
2342527930
-
Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion
-
doi:10.1158/0008-5472.CAN-03-3465
-
Hutchinson JN, Jin J, Cardiff RD, Woodgett JR & Muller WJ 2004 Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Research 64 3171-3178. (doi:10.1158/0008-5472.CAN-03-3465)
-
(2004)
Cancer Research
, vol.64
, pp. 3171-3178
-
-
Hutchinson, J.N.1
Jin, J.2
Cardiff, R.D.3
Woodgett, J.R.4
Muller, W.J.5
-
13
-
-
79251512978
-
mTOR expression and activity patterns in gastroenteropancreatic neuroendocrine tumours
-
doi:10.1677/ERC-10-0126
-
Kasajima A, Pavel M, Darb-Esfahani S, Noske A, Stenzinger A, Sasano H, Dietel M, Denkert C, Rocken C, Wiedenmann B et al. 2011 mTOR expression and activity patterns in gastroenteropancreatic neuroendocrine tumours. Endocrine-Related Cancer 18 181-192. (doi:10.1677/ERC-10-0126)
-
(2011)
Endocrine-Related Cancer
, vol.18
, pp. 181-192
-
-
Kasajima, A.1
Pavel, M.2
Darb-Esfahani, S.3
Noske, A.4
Stenzinger, A.5
Sasano, H.6
Dietel, M.7
Denkert, C.8
Rocken, C.9
Wiedenmann, B.10
-
14
-
-
34548266099
-
AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines
-
doi:10.4161/cbt.6.5.3995
-
Koseoglu S, Lu Z, Kumar C, Kirschmeier P & Zou J 2007 AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines. Cancer Biology & Therapy 6 755-762. (doi:10.4161/cbt.6.5.3995)
-
(2007)
Cancer Biology & Therapy
, vol.6
, pp. 755-762
-
-
Koseoglu, S.1
Lu, Z.2
Kumar, C.3
Kirschmeier, P.4
Zou, J.5
-
15
-
-
84863011775
-
Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration
-
doi:10.1111/j.1349-7006.2011.02025.x
-
Lee MW, Kim DS, Lee JH, Lee BS, Lee SH, Jung HL, Sung KW, Kim HT, Yoo KH & Koo HH 2011 Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration. Cancer Science 102 1822-1828. (doi:10.1111/j.1349-7006.2011.02025.x)
-
(2011)
Cancer Science
, vol.102
, pp. 1822-1828
-
-
Lee, M.W.1
Kim, D.S.2
Lee, J.H.3
Lee, B.S.4
Lee, S.H.5
Jung, H.L.6
Sung, K.W.7
Kim, H.T.8
Yoo, K.H.9
Koo, H.H.10
-
16
-
-
0142227019
-
Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
-
doi:10.1016/S1535-6108(03)00248-4
-
Luo J, Manning BD & Cantley LC 2003 Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4 257-262. (doi:10.1016/S1535-6108(03)00248-4)
-
(2003)
Cancer Cell
, vol.4
, pp. 257-262
-
-
Luo, J.1
Manning, B.D.2
Cantley, L.C.3
-
17
-
-
33947243276
-
PHLPPing it off: Phosphatases get in the Akt
-
doi:10.1016/j.molcel.2007.03.007
-
Mendoza MC & Blenis J 2007 PHLPPing it off: phosphatases get in the Akt. Molecular Cell 25 798-800. (doi:10.1016/j.molcel.2007.03.007)
-
(2007)
Molecular Cell
, vol.25
, pp. 798-800
-
-
Mendoza, M.C.1
Blenis, J.2
-
18
-
-
23844457178
-
Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo
-
doi:10.1158/0008-5472.CAN-05-1042
-
Momota H, Nerio E & Holland EC 2005 Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Research 65 7429-7435. (doi:10.1158/0008-5472.CAN-05-1042)
-
(2005)
Cancer Research
, vol.65
, pp. 7429-7435
-
-
Momota, H.1
Nerio, E.2
Holland, E.C.3
-
19
-
-
77952309277
-
Akt2 and Akt3 play a pivotal role in malignant gliomas
-
doi:10.1093/neuonc/nop026
-
Mure H, Matsuzaki K, Kitazato KT, Mizobuchi Y, Kuwayama K, Kageji T & Nagahiro S 2010 Akt2 and Akt3 play a pivotal role in malignant gliomas. Neuro-Oncology 12 221-232. (doi:10.1093/neuonc/nop026)
-
(2010)
Neuro-Oncology
, vol.12
, pp. 221-232
-
-
Mure, H.1
Matsuzaki, K.2
Kitazato, K.T.3
Mizobuchi, Y.4
Kuwayama, K.5
Kageji, T.6
Nagahiro, S.7
-
20
-
-
0025726216
-
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
-
doi:10.1016/0022-1759(91)90198-O
-
Nicoletti I, Migliorati G, Pagliacci MC, Grignani F &Riccardi C 1991 A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. Journal of Immunological Methods 139 271-279. (doi:10.1016/0022-1759(91)90198-O)
-
(1991)
Journal of Immunological Methods
, vol.139
, pp. 271-279
-
-
Nicoletti, I.1
Migliorati, G.2
Pagliacci, M.C.3
Grignani, F.4
Riccardi, C.5
-
21
-
-
32944457518
-
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
doi:10.1158/0008-5472.CAN-05-2925
-
O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, Lane H, Hofmann F, Hicklin DJ, Ludwig DL et al. 2006 mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Research 66 1500-1508. (doi:10.1158/0008-5472.CAN-05-2925)
-
(2006)
Cancer Research
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
Lane, H.7
Hofmann, F.8
Hicklin, D.J.9
Ludwig, D.L.10
-
22
-
-
83255167036
-
Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associatedwith carcinoid syndrome(RADIANT-2): A randomised, placebo-controlled, phase 3 study
-
doi:10.1016/S0140-6736(11)61742-X
-
Pavel ME, Hainsworth JD, Baudin E, Peeters M, Horsch D, Winkler RE, Klimovsky J, Lebwohl D, Jehl V, Wolin EM et al. 2011 Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associatedwith carcinoid syndrome(RADIANT-2): a randomised, placebo-controlled, phase 3 study. Lancet 378 2005-2012. (doi:10.1016/S0140-6736(11)61742-X)
-
(2011)
Lancet
, vol.378
, pp. 2005-2012
-
-
Pavel, M.E.1
Hainsworth, J.D.2
Baudin, E.3
Peeters, M.4
Horsch, D.5
Winkler, R.E.6
Klimovsky, J.7
Lebwohl, D.8
Jehl, V.9
Wolin, E.M.10
-
23
-
-
15944406971
-
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species
-
doi:10.1158/0008-5472.CAN-04-2440
-
Rahmani M, Reese E, Dai Y, Bauer C, Payne SG, Dent P, Spiegel S & Grant S 2005 Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer Research 65 2422-2432. (doi:10.1158/0008-5472.CAN-04-2440)
-
(2005)
Cancer Research
, vol.65
, pp. 2422-2432
-
-
Rahmani, M.1
Reese, E.2
Dai, Y.3
Bauer, C.4
Payne, S.G.5
Dent, P.6
Spiegel, S.7
Grant, S.8
-
24
-
-
81155151824
-
Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: Results of a multicenter phase I/II trial
-
doi:10.1200/JCO.2010.33.9788
-
Richardson PG, Wolf J, Jakubowiak A, Zonder J, Lonial S, Irwin D, Densmore J, Krishnan A, Raje N, Bar M et al. 2011 Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trial. Journal of Clinical Oncology 29 4243-4249. (doi:10.1200/JCO.2010.33.9788)
-
(2011)
Journal of Clinical Oncology
, vol.29
, pp. 4243-4249
-
-
Richardson, P.G.1
Wolf, J.2
Jakubowiak, A.3
Zonder, J.4
Lonial, S.5
Irwin, D.6
Densmore, J.7
Krishnan, A.8
Raje, N.9
Bar, M.10
-
25
-
-
80054963481
-
Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer
-
doi:10.1038/onc.2011.136
-
Saji M, Narahara K, McCarty SK, Vasko VV, La Perle KM, Porter K, Jarjoura D, Lu C, Cheng SY & Ringel MD 2011 Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer. Oncogene 30 4307-4315. (doi:10.1038/onc.2011.136)
-
(2011)
Oncogene
, vol.30
, pp. 4307-4315
-
-
Saji, M.1
Narahara, K.2
McCarty, S.K.3
Vasko, V.V.4
La Perle, K.M.5
Porter, K.6
Jarjoura, D.7
Lu, C.8
Cheng, S.Y.9
Ringel, M.D.10
-
26
-
-
33746104821
-
Will kinase inhibitors have a dark side?
-
doi:10.1056/NEJMcibr062354
-
Sawyers CL 2006 Will kinase inhibitors have a dark side? New England Journal of Medicine 355 313-315. (doi:10.1056/NEJMcibr062354)
-
(2006)
New England Journal of Medicine
, vol.355
, pp. 313-315
-
-
Sawyers, C.L.1
-
27
-
-
33645457528
-
Epidermal growth factor receptor expression and activation in neuroendocrine tumours
-
doi:10.1111/j.1365-2826.2006.01425.x
-
Shah T, Hochhauser D, Frow R, Quaglia A, Dhillon AP &Caplin ME 2006 Epidermal growth factor receptor expression and activation in neuroendocrine tumours. Journal of Neuroendocrinology 18 355-360. (doi:10.1111/j.1365-2826. 2006.01425.x)
-
(2006)
Journal of Neuroendocrinology
, vol.18
, pp. 355-360
-
-
Shah, T.1
Hochhauser, D.2
Frow, R.3
Quaglia, A.4
Dhillon, A.P.5
Caplin, M.E.6
-
28
-
-
4944249733
-
Deregulated Akt3 activity promotes development of malignant melanoma
-
doi:10.1158/0008-5472.CAN-04-1399
-
Stahl JM, Sharma A, Cheung M, Zimmerman M, Cheng JQ, Bosenberg MW, Kester M, Sandirasegarane L &Robertson GP 2004 Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Research 64 7002-7010. (doi:10.1158/0008-5472.CAN-04-1399)
-
(2004)
Cancer Research
, vol.64
, pp. 7002-7010
-
-
Stahl, J.M.1
Sharma, A.2
Cheung, M.3
Zimmerman, M.4
Cheng, J.Q.5
Bosenberg, M.W.6
Kester, M.7
Sandirasegarane, L.8
Robertson, G.P.9
-
29
-
-
33747889727
-
Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration
-
doi:10.1016/j.tcb.2006.07.001
-
Stambolic V & Woodgett JR 2006 Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration. Trends in Cell Biology 16 461-466. (doi:10.1016/j.tcb.2006.07.001)
-
(2006)
Trends in Cell Biology
, vol.16
, pp. 461-466
-
-
Stambolic, V.1
Woodgett, J.R.2
-
30
-
-
80052448870
-
Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT
-
doi:10.1002/cncr.26011
-
Svejda B, Kidd M, Kazberouk A, Lawrence B, Pfragner R &Modlin IM 2011 Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT. Cancer 117 4141-4154. (doi:10.1002/cncr.26011)
-
(2011)
Cancer
, vol.117
, pp. 4141-4154
-
-
Svejda, B.1
Kidd, M.2
Kazberouk, A.3
Lawrence, B.4
Pfragner, R.5
Modlin, I.M.6
-
31
-
-
23144449547
-
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis
-
doi:10.1242/dev.01864
-
Tschopp O, Yang ZZ, Brodbeck D, Dummler BA, Hemmings-Mieszczak M, Watanabe T, Michaelis T, Frahm J & Hemmings BA 2005 Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development 132 2943-2954. (doi:10.1242/dev.01864)
-
(2005)
Development
, vol.132
, pp. 2943-2954
-
-
Tschopp, O.1
Yang, Z.Z.2
Brodbeck, D.3
Dummler, B.A.4
Hemmings-Mieszczak, M.5
Watanabe, T.6
Michaelis, T.7
Frahm, J.8
Hemmings, B.A.9
-
32
-
-
33645047901
-
Radiosensitization of squamous cell carcinoma by the alkylphospholipid perifosine in cell culture and xenografts
-
doi:10.1158/1078-0432.CCR-05-2033
-
Vink SR, Lagerwerf S, Mesman E, Schellens JH, Begg AC, van Blitterswijk WJ & Verheij M 2006 Radiosensitization of squamous cell carcinoma by the alkylphospholipid perifosine in cell culture and xenografts. Clinical Cancer Research 12 1615-1622. (doi:10.1158/1078-0432.CCR-05-2033)
-
(2006)
Clinical Cancer Research
, vol.12
, pp. 1615-1622
-
-
Vink, S.R.1
Lagerwerf, S.2
Mesman, E.3
Schellens, J.H.4
Begg, A.C.5
Van Blitterswijk, W.J.6
Verheij, M.7
-
33
-
-
3042841621
-
SOCS-1 and SOCS-3 inhibit IFN-alpha-induced expression of the antiviral proteins 2,5-OAS and MxA
-
doi:10.1016/j.bbrc.2004.06.051
-
Vlotides G, Sorensen AS, Kopp F, Zitzmann K, Cengic N, Brand S, Zachoval R & Auernhammer CJ 2004 SOCS-1 and SOCS-3 inhibit IFN-alpha-induced expression of the antiviral proteins 2,5-OAS and MxA. Biochemical and Biophysical Research Communications 320 1007-1014. (doi:10.1016/j.bbrc.2004.06. 051)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.320
, pp. 1007-1014
-
-
Vlotides, G.1
Sorensen, A.S.2
Kopp, F.3
Zitzmann, K.4
Cengic, N.5
Brand, S.6
Zachoval, R.7
Auernhammer, C.J.8
-
34
-
-
0036001209
-
Differential expression of the PTEN tumor suppressor protein in fetal and adult neuroendocrine tissues and tumors: Progressive loss of PTEN expression in poorly differentiated neuroendocrine neoplasms
-
doi:10.1097/00022744-200206000-00008
-
Wang L, Ignat A & Axiotis CA 2002 Differential expression of the PTEN tumor suppressor protein in fetal and adult neuroendocrine tissues and tumors: progressive loss of PTEN expression in poorly differentiated neuroendocrine neoplasms. Applied Immunohistochemistry & Molecular Morphology 10 139-146. (doi:10.1097/00022744-200206000-00008)
-
(2002)
Applied Immunohistochemistry & Molecular Morphology
, vol.10
, pp. 139-146
-
-
Wang, L.1
Ignat, A.2
Axiotis, C.A.3
-
35
-
-
79851500081
-
Everolimus for advanced pancreatic neuroendocrine tumors
-
doi:10.1056/NEJMoa1009290
-
Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E, Hobday TJ, Okusaka T, Capdevila J, de Vries EG et al. 2011 Everolimus for advanced pancreatic neuroendocrine tumors. New England Journal of Medicine 364 514-523. (doi:10.1056/NEJMoa1009290)
-
(2011)
New England Journal of Medicine
, vol.364
, pp. 514-523
-
-
Yao, J.C.1
Shah, M.H.2
Ito, T.3
Bohas, C.L.4
Wolin, E.M.5
Van Cutsem, E.6
Hobday, T.J.7
Okusaka, T.8
Capdevila, J.9
De Vries, E.G.10
-
36
-
-
67650065524
-
Reduction of Akt2 inhibits migration and invasion of glioma cells
-
doi:10.1002/ijc.24314
-
Zhang B, Gu F, She C, Guo H, Li W, Niu R, Fu L, Zhang N &Ma Y 2009 Reduction of Akt2 inhibits migration and invasion of glioma cells. International Journal of Cancer 125 585-595. (doi:10.1002/ijc.24314)
-
(2009)
International Journal of Cancer
, vol.125
, pp. 585-595
-
-
Zhang, B.1
Gu, F.2
She, C.3
Guo, H.4
Li, W.5
Niu, R.6
Fu, L.7
Zhang, N.8
Ma, Y.9
-
37
-
-
33646184947
-
Novel interferon-lambdas induce antiproliferative effects in neuroendocrine tumor cells
-
doi:10.1016/j.bbrc.2006.04.043
-
Zitzmann K, Brand S, Baehs S, Goke B, Meinecke J, Spottl G, Meyer H & Auernhammer CJ 2006 Novel interferon-lambdas induce antiproliferative effects in neuroendocrine tumor cells. Biochemical and Biophysical Research Communications 344 1334-1341. (doi:10.1016/j.bbrc.2006.04.043)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.344
, pp. 1334-1341
-
-
Zitzmann, K.1
Brand, S.2
Baehs, S.3
Goke, B.4
Meinecke, J.5
Spottl, G.6
Meyer, H.7
Auernhammer, C.J.8
-
38
-
-
77953609118
-
Compensatory activation of Akt in response to mTOR and Raf inhibitors - A rationale for dual-targeted therapy approaches in neuroendocrine tumor disease
-
doi:10.1016/j.canlet.2010.02.018
-
Zitzmann K, Ruden J, Brand S, Goke B, Lichtl J, Spottl G &Auernhammer CJ 2010 Compensatory activation of Akt in response to mTOR and Raf inhibitors - a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease. Cancer Letters 295 100-109. (doi:10.1016/j.canlet.2010.02.018)
-
(2010)
Cancer Letters
, vol.295
, pp. 100-109
-
-
Zitzmann, K.1
Ruden, J.2
Brand, S.3
Goke, B.4
Lichtl, J.5
Spottl, G.6
Auernhammer, C.J.7
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