Formulation and in vitro characterization of composite biodegradable magnetic nanoparticles for magnetically guided cell delivery

Pharmaceutical Research

Volumn 29, Issue 5, 2012, Pages 1232-1241

  Chorny, Michael ^a   Alferiev, Ivan S ^a   Fishbein, Ilia ^a   Tengood, Jillian E ^a   Folchman Wagner, Zoë ^a   Forbes, Scott P ^a   Levy, Robert J ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Biodegradable nanoparticle; Cell therapy; Magnetic targeting; Restenosis; Stent angioplasty; Vascular disease

Indexed keywords

ADENOVIRUS VECTOR; GREEN FLUORESCENT PROTEIN; MAGNETIC NANOPARTICLE; POLYLACTIDE;

ADENOVIRUS; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIODEGRADABILITY; CELL THERAPY; CELL TRANSPORT; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; COW; EMULSION; GENE TRANSFER; IN VITRO STUDY; MAGNETIC FIELD; NANOFABRICATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SEDIMENTATION RATE; STRUCTURE ANALYSIS; VIRUS REPLICATION;

ABSORBABLE IMPLANTS; ANIMALS; CATTLE; CELL SURVIVAL; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ENDOTHELIAL CELLS; FERUMOXYTOL; FLUORESCENT DYES; GENE TRANSFER TECHNIQUES; KINETICS; MAGNETICS; MOLECULAR STRUCTURE; NANOPARTICLES; PARTICLE SIZE; POLYESTERS; SURFACE-ACTIVE AGENTS;

EID: 84862681260     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0675-y     Document Type: Article

References (26)

1. Schlorf T, Meincke M, Kossel E, Gluer CC, Jansen O, Mentlein R. Biological properties of iron oxide nanoparticles for cellular and molecular magnetic resonance imaging. Int J Mol Sci. 2011;12(1):12-23.
2. Sykova E, Jendelova P, Herynek V. MR tracking of stem cells in living recipients. Methods Mol Biol. 2009;549:197-215.
3. Pislaru SV, Harbuzariu A, Agarwal G, Witt T, Gulati R, Sandhu NP, et al. Magnetic forces enable rapid endothelialization of synthetic vascular grafts. Circulation. 2006;114(1 Suppl):I314-8.
4. Pislaru SV, Harbuzariu A, Gulati R, Witt T, Sandhu NP, Simari RD, et al. Magnetically targeted endothelial cell localization in stented vessels. J Am Coll Cardiol. 2006;48(9):1839-45.
5. Kyrtatos PG, Lehtolainen P, Junemann-Ramirez M, Garcia-Prieto A, Price AN, Martin JF, et al. Magnetic tagging increases delivery of circulating progenitors in vascular injury. JACC Cardiovasc Interv. 2009;2(8):794-802.
6. Hofmann A, Wenzel D, Becher UM, Freitag DF, Klein AM, Eberbeck D, et al. Combined targeting of lentiviral vectors and positioning of transduced cells by magnetic nanoparticles. Proc Natl Acad Sci U S A. 2009;106(1):44-9.
7. Polyak B, Fishbein I, Chorny M, Alferiev I, Williams D, Yellen B, et al. High field magnetic gradients can target magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents. Proc Natl Acad Sci U S A. 2008;105(2):698-703.
8. Shimizu K, Ito A, Arinobe M, Murase Y, Iwata Y, Narita Y, et al. Effective cell-seeding technique using magnetite nanoparticles and magnetic force onto decellularized blood vessels for vascular tissue engineering. J Biosci Bioeng. 2007;103(5):472-8.
9. Muthana M, Scott SD, Farrow N, Morrow F, Murdoch C, Grubb S, et al. A novel magnetic approach to enhance the efficacy of cell-based gene therapies. Gene Ther. 2008;15(12):902-10.
10. Fishbein I, Chorny M, Levy RJ. Site-specific gene therapy for cardiovascular disease. Curr Opin Drug Discov Devel. 2010;13 (2):203-13.
11. Soenen SJ, Himmelreich U, Nuytten N, De Cuyper M. Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling. Biomaterials. 2010;32(1):195-205.
12. Nyanguile O, Dancik C, Blakemore J, Mulgrew K, Kaleko M, Stevenson SC. Synthesis of adenoviral targeting molecules by intein-mediated protein ligation. Gene Ther. 2003;10(16):1362-9.
13. Chorny M, Fishbein I, Alferiev IS, Nyanguile O, Gaster R, Levy RJ. Adenoviral gene vector tethering to nanoparticle surfaces results in receptor-independent cell entry and increased transgene expression. Mol Ther. 2006;14(3):382-91.
14. Chorny M, Polyak B, Alferiev IS, Walsh K, Friedman G, Levy RJ. Magnetically driven plasmid DNA delivery with biodegradable polymeric nanoparticles. FASEB J. 2007;21(10):2510-9.
15. Chorny M, Fishbein I, Alferiev I, Levy RJ. Magnetically responsive biodegradable nanoparticles enhance adenoviral gene transfer in cultured smooth muscle and endothelial cells. Mol Pharm. 2009;6 (5):1380-7.
16. Chorny M, Fishbein I, Yellen BB, Alferiev IS, Bakay M, Ganta S, et al. Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields. Proc Natl Acad Sci U S A. 2010;107(18):8346-51.
17. Wilhelm C, Gazeau F, Bacri JC. Rotational magnetic endosome microrheology: viscoelastic architecture inside living cells. Phys Rev E Stat Nonlin Soft Matter Phys. 2003;67(6 Pt 1):061908.
18. Tresilwised N, Pithayanukul P, Mykhaylyk O, Holm PS, Holzmuller R, Anton M, et al. Boosting oncolytic adenovirus potency with magnetic nanoparticles and magnetic force. Mol Pharm. 2010;7 (4):1069-89.
19. Tresilwised N, Pithayanukul P, Holm PS, Schillinger U, Plank C, Mykhaylyk O. Effects of nanoparticle coatings on the activity of oncolytic adenovirus-magnetic nanoparticle complexes. Biomaterials. 2012;33(1):256-69.
20. Mah C, Fraites Jr TJ, Zolotukhin I, Song S, Flotte TR, Dobson J, et al. Improved method of recombinant AAV2 delivery for systemic targeted gene therapy. Mol Ther. 2002;6(1):106-12.
21. Chorny M, Fishbein I, Levy RJ. Endothelial cells transduced with magnetically responsive nanoparticles formulated with iNOS encoding adenovirus inhibit proliferation of aortic smooth muscle cells in a direct co-culture model. Mol Ther. 2009;17:S393.
22. Huth S, Lausier J, Gersting SW, Rudolph C, Plank C, Welsch U, et al. Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer. J Gene Med. 2004;6(8):923-36.
23. Chorny M, Fishbein I, Forbes S, Alferiev I. Magnetic nanoparticles for targeted vascular delivery. IUBMB Life. 2011;63(8):613-20.
24. Kempe H, Kates SA, Kempe M. Nanomedicine's promising therapy: magnetic drug targeting. Expert Rev Med Devices. 2011;8 (3):291-4.
25. Astete CE, Sabliov CM. Synthesis and characterization of PLGA nanoparticles. J Biomater Sci Polym Ed. 2006;17(3):247-89.
26. Chorny M, Fishbein I, Danenberg HD, Golomb G. Lipophilic drug loaded nanospheres prepared by nanoprecipitation: effect of formulation variables on size, drug recovery and release kinetics. J Control Release. 2002;83(3):389-400.