Magnetic nanoparticles for targeted vascular delivery

IUBMB Life

Volumn 63, Issue 8, 2011, Pages 613-620

  Chorny, Michael ^a   Fishbein, Ilia ^a   Forbes, Scott ^a   Alferiev, Ivan ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

biodegradable nanoparticle; drug delivery; gene therapy; magnetic targeting; restenosis; stent angioplasty; vascular disease

Indexed keywords

ADENOVIRUS VECTOR; ANTIGEN; CATALASE; MAGNETIC NANOPARTICLE; PACLITAXEL; POLYGLACTIN; POLYLACTIDE; SUPEROXIDE DISMUTASE;

BINDING AFFINITY; BIOCOMPATIBILITY; CARDIOVASCULAR SYSTEM; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; FEASIBILITY STUDY; GENE VECTOR; HUMAN; IN-STENT RESTENOSIS; MAGNETIC FIELD; MAGNETISM; NONHUMAN; REVIEW; SAFETY; STENT;

BLOOD VESSELS; HUMANS; MAGNETICS; NANOPARTICLES;

EID: 79960791273     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.479     Document Type: Review

References (66)

1. Grief, A. D., and, Richardson, G., (2005) Mathematical modelling of magnetically targeted drug delivery. J. Magn. Magn. Mater. 293, 455-463. (Pubitemid 40608966)
2. Yellen, B. B., Forbes, Z. G., Halverson, D. S., Fridman, G., Barbee, K. A., Chorny, M., Levy, R., and, Friedman, G., (2005) Targeted drug delivery to magnetic implants for therapeutic applications. J. Magn. Magn. Mater. 293, 647-654. (Pubitemid 40608991)
3. Chorny, M., Fishbein, I., Yellen, B. B., Alferiev, I. S., Bakay, M., Ganta, S., Adamo, R., Amiji, M., Friedman, G., and, Levy, R. J., (2010) Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields. Proc. Natl. Acad. Sci. USA 107, 8346-8351.
4. Lubbe, A. S., Alexiou, C., and, Bergemann, C., (2001) Clinical applications of magnetic drug targeting. J. Surg. Res. 95, 200-206. (Pubitemid 34953556)
5. Alexiou, C., Schmid, R. J., Jurgons, R., Kremer, M., Wanner, G., Bergemann, C., Huenges, E., Nawroth, T., Arnold, W., and, Parak, F. G., (2006) Targeting cancer cells: magnetic nanoparticles as drug carriers. Eur. Biophys. J. 35, 446-450.
6. Goodwin, S., Peterson, C., Hoh, C., and, Bittner, C., (1999) Targeting and retention of magnetic targeted carriers (MTCs) enhancing intra-arterial chemotherapy. J. Magn. Magn. Mater. 194, 132-139.
7. Neuberger, T., Schöpf, B., Hofmann, H., Hofmann, M., and, von Rechenberg, B., (2005) Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system. J. Magn. Magn. Mater. 293, 483-496. (Pubitemid 40608969)
8. Kubo, T., Sugita, T., Shimose, S., Nitta, Y., Ikuta, Y., and, Murakami, T., (2001) Targeted systemic chemotherapy using magnetic liposomes with incorporated adriamycin for osteosarcoma in hamsters. Int. J. Oncol. 18, 121-125.
9. Pislaru, S. V., Harbuzariu, A., Agarwal, G., Witt, T., Gulati, R., Sandhu, N. P., Mueske, C., Kalra, M., Simari, R. D., and, Sandhu, G. S., (2006) Magnetic forces enable rapid endothelialization of synthetic vascular grafts. Circulation 114, I314-I318. (Pubitemid 44297169)
10. Pislaru, S. V., Harbuzariu, A., Gulati, R., Witt, T., Sandhu, N. P., Simari, R. D., and, Sandhu, G. S., (2006) Magnetically targeted endothelial cell localization in stented vessels. J. Am. Coll. Cardiol. 48, 1839-1845. (Pubitemid 44648636)
11. Asmatulu, R., Zalich, M. A., Claus, R. O., and, Riffle, J. S., (2005) Synthesis, characterization and targeting of biodegradable magnetic nanocomposite particles by external magnetic fields. J. Magn. Magn. Mater. 292, 108-119. (Pubitemid 40423107)
12. Mathieu, J. B., and, Martel, S., (2007) Magnetic microparticle steering within the constraints of an MRI system: proof of concept of a novel targeting approach. Biomed. Microdevices 9, 801-808. (Pubitemid 350020674)
13. Kyrtatos, P. G., Lehtolainen, P., Junemann-Ramirez, M., Garcia-Prieto, A., Price, A. N., Martin, J. F., Gadian, D. G., Pankhurst, Q. A., and, Lythgoe, M. F., (2009) Magnetic tagging increases delivery of circulating progenitors in vascular injury. JACC Cardiovasc. Interv. 2, 794-802.
14. Mathieu, J. B., and, Martel, S., (2010) Steering of aggregating magnetic microparticles using propulsion gradients coils in an MRI Scanner. Magn. Reson. Med. 63, 1336-1345.
15. Riegler, J., Wells, J. A., Kyrtatos, P. G., Price, A. N., Pankhurst, Q. A., and, Lythgoe, M. F., (2010) Targeted magnetic delivery and tracking of cells using a magnetic resonance imaging system. Biomaterials 31, 5366-5371.
16. Amirfazli, A., (2007) Nanomedicine: magnetic nanoparticles hit the target. Nat. Nanotechnol. 2, 467-468. (Pubitemid 47220076)
17. Avilés, M. O., Ebner, A. D., and, Ritter, J. A., (2008) Implant assisted-magnetic drug targeting: comparison of in vitro experiments with theory. J. Magn. Magn. Mater. 320, 2704-2713.
18. Polyak, B., Fishbein, I., Chorny, M., Alferiev, I., Williams, D., Yellen, B., Friedman, G., and, Levy, R. J., (2008) High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents. Proc. Natl. Acad. Sci. USA 105, 698-703. (Pubitemid 351171771)
19. Kempe, H., and, Kempe, M., (2010) The use of magnetite nanoparticles for implant-assisted magnetic drug targeting in thrombolytic therapy. Biomaterials 31, 9499-9510.
20. Kiemeneij, F., Patterson, M. S., Amoroso, G., Laarman, G., and, Slagboom, T., (2008) Use of the Stereotaxis Niobe magnetic navigation system for percutaneous coronary intervention: results from 350 consecutive patients. Catheter. Cardiovasc. Interv. 71, 510-516. (Pubitemid 351498094)
21. Weissleder, R., Stark, D. D., Engelstad, B. L., Bacon, B. R., Compton, C. C., White, D. L., Jacobs, P., and, Lewis, J., (1989) Superparamagnetic iron oxide: pharmacokinetics and toxicity. AJR Am. J. Roentgenol. 152, 167-173. (Pubitemid 19024086)
22. Hiramoto, J. S., Reilly, L. M., Schneider, D. B., Skorobogaty, H., Rapp, J., and, Chuter, T. A., (2007) The effect of magnetic resonance imaging on stainless-steel Z-stent-based abdominal aortic prosthesis. J. Vasc. Surg. 45, 472-474. (Pubitemid 46281521)
23. Chorny, M., Cohen-Sacks, H., Fishbein, I., Danenberg, H. D., and, Golomb, G., (2004) Biodegradable nanoparticles as drug delivery systems for parenteral administration. In Tissue Engineering and Novel Delivery Systems (, Yaszemsky, M. J., Trantolo, D. J., Lewandrowski, K.-U., Hasirci, V., Altobelli, D. E., and, Wise, D. L., eds.). pp. 393-422, Marcel Dekker, New York.
24. Gupta, A. K., and, Gupta, M., (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26, 3995-4021. (Pubitemid 40044762)
25. 4, B=Mn, Co (x=0-1)] for biomedical applications. J. Magn. Magn. Mater. 320, 724-730.
26. Hadjipanayis, C. G., Bonder, M. J., Balakrishnan, S., Wang, X., Mao, H., and, Hadjipanayis, G. C., (2008) Metallic iron nanoparticles for MRI contrast enhancement and local hyperthermia. Small 4, 1925-1929.
27. Dobson, J., (2006) Magnetic nanoparticles for drug delivery. Drug Dev. Res. 67, 55-60. (Pubitemid 43765049)
28. Nakazawa, G., Ladich, E., Finn, A. V., and, Virmani, R., (2008) Pathophysiology of vascular healing and stent mediated arterial injury. EuroIntervention 4 (Suppl C), C7-C10.
29. Aminian, A., Kabir, T., and, Eeckhout, E., (2009) Treatment of drug-eluting stent restenosis: an emerging challenge. Catheter. Cardiovasc. Interv. 74, 108-116.
30. Umashankar, P. R., Hari, P. R., and, Sreenivasan, K., (2009) Effect of blood flow on drug release from DES: an experimental study. Int. J. Cardiol. 131, 415-417.
31. van Beusekom, H. M., Schoemaker, R., Roks, A. J., Zijlstra, F., and, van der Giessen, W. J., (2007) Coronary stent healing, endothelialisation and the role of co-medication. Neth. Heart J. 15, 395-396. (Pubitemid 350206883)
32. Kamath, K. R., Barry, J. J., and, Miller, K. M., (2006) The Taxus drug-eluting stent: a new paradigm in controlled drug delivery. Adv. Drug Deliv. Rev. 58, 412-436. (Pubitemid 43949060)
33. Farb, A., Heller, P. F., Shroff, S., Cheng, L., Kolodgie, F. D., Carter, A. J., Scott, D. S., Froehlich, J., and, Virmani, R., (2001) Pathological analysis of local delivery of paclitaxel via a polymer-coated stent. Circulation 104, 473-479. (Pubitemid 32678280)
34. Závisová, V., Koneracká, M., Múcková, M., Kopcanský, P., Tomasovicová, N., Lancz, G., Timko, M., Pätoprstá, B., Bartos, P., and, Fabián, M., (2009) Synthesis and characterization of polymeric nanospheres loaded with the anticancer drug paclitaxel and magnetic particles. J. Magn. Magn. Mater. 321, 1613-1616.
35. Verrecchia, T., Spenlehauer, G., Bazile, D. V., Murry-Brelier, A., Archimbaud, Y., and, Veillard, M., (1995) Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers. J. Control. Release 36, 49-61.
36. Chorny, M., Fishbein, I., Danenberg, H. D., and, Golomb, G., (2002) Study of the drug release mechanism from tyrphostin AG-1295-loaded nanospheres by in situ and external sink methods. J. Control. Release 83, 401-414. (Pubitemid 35223262)
37. Washington, C., (1990) Drug release from microdisperse systems: a critical review. Int. J. Pharm. 58, 1-12. (Pubitemid 20034221)
38. Washington, C., (1989) Evaluation of non-sink dialysis methods for the measurement of drug release from colloids: effects of drug partition. Int. J. Pharm. 56, 71-74. (Pubitemid 19274692)
39. Vassileva, V., Grant, J., De Souza, R., Allen, C., and, Piquette-Miller, M., (2007) Novel biocompatible intraperitoneal drug delivery system increases tolerability and therapeutic efficacy of paclitaxel in a human ovarian cancer xenograft model. Cancer Chemother. Pharmacol. 60, 907-914. (Pubitemid 47389398)
40. Song, C., Labhasetwar, V., Cui, X., Underwood, T., and, Levy, R. J., (1998) Arterial uptake of biodegradable nanoparticles for intravascular local drug delivery: results with an acute dog model. J. Control. Release 54, 201-211. (Pubitemid 28342699)
41. Chan, J. M., Zhang, L., Tong, R., Ghosh, D., Gao, W., Liao, G., Yuet, K. P., Gray, D., Rhee, J. W., Cheng, J., Golomb, G., Libby, P., Langer, R., and, Farokhzad, O. C., (2010) Spatiotemporal controlled delivery of nanoparticles to injured vasculature. Proc. Natl. Acad. Sci. USA 107, 2213-2218.
42. Maa, Y. F., and, Hsu, C. C., (1997) Protein denaturation by combined effect of shear and air-liquid interface. Biotechnol. Bioeng. 54, 503-512. (Pubitemid 27209319)
43. Maa, Y. F., and, Hsu, C. C., (1996) Effect of high shear on proteins. Biotechnol. Bioeng. 51, 458-465. (Pubitemid 26313480)
44. Zambaux, M. F., Bonneaux, F., Gref, R., Dellacherie, E., and, Vigneron, C., (1999) Preparation and characterization of protein C-loaded PLA nanoparticles. J. Control. Release 60, 179-188. (Pubitemid 29335944)
45. Mok, H., Park, J. W., and, Park, T. G., (2007) Microencapsulation of PEGylated adenovirus within PLGA microspheres for enhanced stability and gene transfection efficiency. Pharm. Res. 24, 2263-2269. (Pubitemid 350060718)
46. Schwendeman, S. P., (2002) Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems. Crit. Rev. Ther. Drug Carrier Syst. 19, 73-98. (Pubitemid 34521249)
47. Rexroad, J., Evans, R. K., and, Middaugh, C. R., (2006) Effect of pH and ionic strength on the physical stability of adenovirus type 5. J. Pharm. Sci. 95, 237-247. (Pubitemid 43241967)
48. Mah, C., Fraites, T. J. Jr. , Zolotukhin, I., Song, S., Flotte, T. R., Dobson, J., Batich, C., and, Byrne, B. J., (2002) Improved method of recombinant AAV2 delivery for systemic targeted gene therapy. Mol. Ther. 6, 106-112. (Pubitemid 36124277)
49. Kadota, S., Kanayama, T., Miyajima, N., Takeuchi, K., and, Nagata, K., (2005) Enhancing of measles virus infection by magnetofection. J. Virol. Methods 128, 61-66. (Pubitemid 40980210)
50. Morishita, N., Nakagami, H., Morishita, R., Takeda, S., Mishima, F., Terazono, B., Nishijima, S., Kaneda, Y., and, Tanaka, N., (2005) Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector. Biochem. Biophys. Res. Commun. 334, 1121-1126. (Pubitemid 41074690)
51. Tresilwised, N., Pithayanukul, P., Mykhaylyk, O., Holm, P. S., Holzmuller, R., Anton, M., Thalhammer, S., Adiguzel, D., Doblinger, M., and, Plank, C., (2010) Boosting oncolytic adenovirus potency with magnetic nanoparticles and magnetic force. Mol. Pharm. 7, 1069-1089.
52. Chorny, M., Polyak, B., Alferiev, I. S., Walsh, K., Friedman, G., and, Levy, R. J., (2007) Magnetically driven plasmid DNA delivery with biodegradable polymeric nanoparticles. FASEB J. 21, 2510-2519. (Pubitemid 47230680)
53. Chorny, M., Fishbein, I., Alferiev, I., and, Levy, R. J., (2009) Magnetically responsive biodegradable nanoparticles enhance adenoviral gene transfer in cultured smooth muscle and endothelial cells. Mol. Pharm. 6, 1380-1387.
54. Baker, A. H., (2004) Designing gene delivery vectors for cardiovascular gene therapy. Prog. Biophys. Mol. Biol. 84, 279-299. (Pubitemid 38215216)
55. Chorny, M., Fishbein, I., Alferiev, I. S., Nyanguile, O., Gaster, R., and, Levy, R. J., (2006) Adenoviral gene vector tethering to nanoparticle surfaces results in receptor-independent cell entry and increased transgene expression. Mol. Ther. 14, 382-391. (Pubitemid 44184965)
56. Chorny, M., Hood, E., Levy, R. J., and, Muzykantov, V. R., (2010) Endothelial delivery of antioxidant enzymes loaded into non-polymeric magnetic nanoparticles. J. Control. Release 146, 144-151.
57. Parikh, S. A., and, Edelman, E. R., (2000) Endothelial cell delivery for cardiovascular therapy. Adv. Drug Deliv. Rev. 42, 139-161. (Pubitemid 30609639)
58. Kipshidze, N., Dangas, G., Tsapenko, M., Moses, J., Leon, M. B., Kutryk, M., and, Serruys, P., (2004) Role of the endothelium in modulating neointimal formation: vasculoprotective approaches to attenuate restenosis after percutaneous coronary interventions. J. Am. Coll. Cardiol. 44, 733-739. (Pubitemid 39099565)
59. Gulati, R., and, Simari, R. D., (2004) Autologous cell-based therapies for vascular disease. Trends Cardiovasc. Med. 14, 262-267. (Pubitemid 39473304)
60. Gulati, R., and, Simari, R. D., (2009) Defining the potential for cell therapy for vascular disease using animal models. Dis. Model. Mech. 2, 130-137.
61. Dichek, D. A., Neville, R. F., Zwiebel, J. A., Freeman, S. M., Leon, M. B., and, Anderson, W. F., (1989) Seeding of intravascular stents with genetically engineered endothelial cells. Circulation 80, 1347-1353. (Pubitemid 19282525)
62. Koren, B., Weisz, A., Fischer, L., Gluzman, Z., Preis, M., Avramovitch, N., Cohen, T., Cosset, F. L., Lewis, B. S., and, Flugelman, M. Y., (2006) Efficient transduction and seeding of human endothelial cells onto metallic stents using bicistronic pseudo-typed retroviral vectors encoding vascular endothelial growth factor. Cardiovasc. Revasc. Med. 7, 173-178. (Pubitemid 44292063)
63. Patel, H. J., Su, S. H., Patterson, C., and, Nguyen, K. T., (2006) A combined strategy to reduce restenosis for vascular tissue engineering applications. Biotechnol. Prog. 22, 38-44. (Pubitemid 43221525)
64. Zhao, Q., Wei, M., and, Zhao, B., (2010) Fabrication of stents with endothelial function in vitro. Scand. Cardiovasc. J. 44, 76-81.
65. Consigny, P. M., Silverberg, D. A., and, Vitali, N. J., (1999) Use of endothelial cells containing superparamagnetic microspheres to improve endothelial cell delivery to arterial surfaces after angioplasty. J. Vasc. Interv. Radiol. 10, 155-163. (Pubitemid 29091709)
66. Hofmann, A., Wenzel, D., Becher, U. M., Freitag, D. F., Klein, A. M., Eberbeck, D., Schulte, M., Zimmermann, K., Bergemann, C., Gleich, B., Roell, W., Weyh, T., Trahms, L., Nickenig, G., Fleischmann, B. K., and, Pfeifer, A., (2009) Combined targeting of lentiviral vectors and positioning of transduced cells by magnetic nanoparticles. Proc. Natl. Acad. Sci. USA 106, 44-49.