The autonomic response to human esophageal acidification and the development of hyperalgesia

Neurogastroenterology and Motility

Volumn 24, Issue 7, 2012, Pages

  Sharma, A ^a   Paine, P ^a   Rhodes, S ^a   Warburton, F ^b   Chua, Y C ^b   Aziz, Q ^b  

^a SALFORD ROYAL NHS FOUNDATION TRUST   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Autonomic nervous system; Central sensitization; Cortisol; Esophagus; Hyperalgesia; Pain

Indexed keywords

HYDROCORTISONE; PLACEBO; SODIUM CHLORIDE;

ADULT; ANXIETY; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; ESOPHAGEAL ACIDIFICATION; ESOPHAGUS DISEASE; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYPERALGESIA; MALE; PAIN THRESHOLD; PREDICTIVE VALUE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SKIN CONDUCTANCE; VAGUS TONE;

ADULT; AUTONOMIC NERVOUS SYSTEM; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ELECTRIC STIMULATION; ESOPHAGUS; FEMALE; HUMANS; HYDROCHLORIC ACID; HYDROGEN-ION CONCENTRATION; HYPERALGESIA; MALE; MIDDLE AGED; PAIN THRESHOLD; YOUNG ADULT;

EID: 84862672553     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2012.01929.x     Document Type: Article

References (39)

1. Kost RG, Straus SE. Postherpetic neuralgia - pathogenesis, treatment, and prevention. N Engl J Med 1996; 335: 32-42.
2. McKendrick MW, Read NW. Irritable bowel syndrome - post salmonella infection. J Infect 1994; 29: 1-3.
3. Fass R, Fennerty MB, Johnson C, Camargo L, Sampliner RE. Correlation of ambulatory 24-hour esophageal pH monitoring results with symptom improvement in patients with noncardiac chest pain due to gastroesophageal reflux disease. J Clin Gastroenterol 1999; 28: 36-9.
4. Iovino P, Azpiroz F, Domingo E, Malagelada JR. The sympathetic nervous system modulates perception and reflex responses to gut distention in humans. Gastroenterology 1995; 108: 680-6.
5. Ness TJ, Fillingim RB, Randich A, Backensto EM, Faught E. Low intensity vagal nerve stimulation lowers human thermal pain thresholds. Pain 2000; 86: 81-5.
6. Ren K, Zhuo M, Randich A, Gebhart GF. Vagal afferent stimulation-produced effects on nociception in capsaicin-treated rats. J Neurophysiol 1993; 69: 1530-40.
7. Tougas G, Spaziani R, Hollerbach S et al. Cardiac autonomic function and oesophageal acid sensitivity in patients with non-cardiac chest pain. Gut 2001; 49: 706-12.
8. Lightman SL, Conway-Campbell BL. The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration. Nat Rev Neurosci 2010; 11: 710-8.
9. Chang L, Sundaresh S, Elliott J et al. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome. Neurogastroenterol Motil 2009; 21: 149-59.
10. Posserud I, Agerforz P, Ekman R, Bjornsson ES, Abrahamsson H, Simren M. Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress. Gut 2004; 53: 1102-8.
11. Sarkar S, Aziz Q, Woolf CJ, Hobson AR, Thompson DG. Contribution of central sensitisation to the development of non-cardiac chest pain. Lancet 2000; 356: 1154-9.
12. Sarkar S, Hobson AR, Hughes A et al. The prostaglandin E2 receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans. Gastroenterology 2003; 124: 18-25.
13. Willert RP, Hobson AR, Delaney C, Hicks KJ, Dewit OE, Aziz Q. Neurokinin-1 receptor antagonism in a human model of visceral hypersensitivity. Aliment Pharmacol Ther 2007; 25: 309-16.
14. Barlow J. Static manometry. In: Evans FD, Buckton GK, eds. Clinical Measurement in Gastroenterology. Volume 1/The Oesophagus. Oxford: Blackwell Sciences, 1997: 16-79.
15. Spielberger CD, Gorsuch RL, Lushene RE Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press, 1970.
16. Julu PO, Kerr AM, Hansen S, Apartopoulos F, Jamal GA. Functional evidence of brain stem immaturity in Rett syndrome. Eur Child Adolesc Psychiatry 1997; 6(Suppl 1): 47-54.
17. Julu PO, Cooper VL, Hansen S, Hainsworth R. Cardiovascular regulation in the period preceding vasovagal syncope in conscious humans. J Physiol 2003; 549: 299-311.
18. Little CJ, Julu PO, Hansen S, Reid SW. Real-time measurement of cardiac vagal tone in conscious dogs. Am J Physiol 1999; 276: H758-65.
19. Eckberg DL. Temporal response patterns of the human sinus node to brief carotid baroreceptor stimuli. J Physiol 1976; 258: 769-82.
20. Julu PO. A linear scale for measuring vagal tone in man. J Auton Pharmacol 1992; 12: 109-15.
21. Dawson ME, Schell AM, Filion DL. The electrodermal system. In: Caccioppo JT, Tassinary LG, Berntson GG, eds. Handbook of Psychophysiology, 2nd edn. Cambridge University Press, 2004: 200-24.
22. Allen JJ, Chambers AS, Towers DN. The many metrics of cardiac chronotropy: a pragmatic primer and a brief comparison of metrics. Biol Psychol 2007; 74: 243-62.
23. Toichi M, Sugiura T, Murai T, Sengoku A. A new method of assessing cardiac autonomic function and its comparison with spectral analysis and coefficient of variation of R-R interval. J Auton Nerv Syst 1997; 62: 79-84.
24. Paine P, Kishor J, Worthen SF, Gregory LJ, Aziz Q. Exploring relationships for visceral and somatic pain with autonomic control and personality. Pain 2009; 144: 236-44.
25. Paine P, Worthen SF, Gregory LJ, Thompson DG, Aziz Q. Personality differences affect brainstem autonomic responses to visceral pain. Neurogastroenterol Motil 2009; 21: e1155-98.
26. Willert RP, Woolf CJ, Hobson AR, Delaney C, Thompson DG, Aziz Q. The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor. Gastroenterology 2004; 126: 683-92.
27. Matthews JNS, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in clinical research. Br Med J 1990; 300: 230-5.
28. Zollei E, Paprika D, Wittmann T et al. Oesophageal acid stimulation in humans: does it alter baroreflex function? Acta Physiol Hung 2003; 90: 109-14.
29. Berntson GG, Bigger J Jr, Eckberg DL et al. Heart rate variability: origins, methods, and interpretive caveats. Psychophysiology 1997; 34: 623-48.
30. Eckberg DL. Sympathovagal balance: a critical appraisal. Circulation 1997; 96: 3224-32.
31. Chen CL, Orr WC. Autonomic responses to heartburn induced by esophageal acid infusion. J Gastroenterol Hepatol 2004; 19: 922-6.
32. Hobson AR, Furlong PL, Aziz Q. Oesophageal afferent pathway sensitivity in non-erosive reflux disease. Neurogastroenterol Motil 2008; 20: 877-83.
33. Hausken T, Svebak S, Wilhelmsen I et al. Low vagal tone and antral dysmotility in patients with functional dyspepsia. Psychosom Med 1993; 55: 12-22.
34. Haug TT, Svebak S, Hausken T, Wilhelmsen I, Berstad A, Ursin H. Low vagal activity as mediating mechanism for the relationship between personality factors and gastric symptoms in functional dyspepsia. Psychosom Med 1994; 56: 181-6.
35. Ahern GL, Sollers JJ, Lane RD et al. Heart rate and heart rate variability changes in the intracarotid sodium amobarbital test. Epilepsia 2001; 42: 912-21.
36. Thayer JF, Friedman BH. Stop that! Inhibition, sensitization, and their neurovisceral concomitants. Scand J Psychol 2002; 43: 123-30.
37. Friedman BH, Thayer JF. Autonomic balance revisited: panic anxiety and heart rate variability. J Psychosom Res 1998; 44: 133-51.
38. Franz DN, Evans MH, Perl ER. Characteristics of viscerosympathetic reflexes in the spinal cat. Am J Physiol 1966; 211: 1292-8.
39. Coote JH, Downman CB, Weber WV. Reflex discharges into thoracic white rami elicited by somatic and visceral afferent excitation. J Physiol 1969; 202: 147-59.