Oesophageal afferent pathway sensitivity in non-erosive reflux disease

Neurogastroenterology and Motility

Volumn 20, Issue 8, 2008, Pages 877-883

  Hobson, A R ^a   Furlong, P L ^b   Aziz, Q ^c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b ASTON UNIVERSITY   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Afferent; Cortical evoked potentials; Electrical; Hypersensitivity; Non erosive reflux disease; Oesophagus

Indexed keywords

ACID;

ADULT; ALTERNATIVE MEDICINE; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTROSTIMULATION; ESOPHAGUS; ESOPHAGUS PAIN; EVOKED RESPONSE; FEMALE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL ENDOSCOPY; HUMAN; LATENT PERIOD; MALE; MANOMETRY; MONITORING; NOCICEPTION; NON EROSIVE REFLUX DISEASE; PAIN THRESHOLD; PERCEPTIVE THRESHOLD; PH; PRIORITY JOURNAL; SCORING SYSTEM; SENSORY NERVE; SENSORY SYSTEM EXAMINATION; VOLUNTEER;

ADULT; AFFERENT PATHWAYS; ELECTRIC STIMULATION; ESOPHAGUS; EVOKED POTENTIALS; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; MANOMETRY; MIDDLE AGED; PAIN THRESHOLD;

EID: 47649094233     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2008.01122.x     Document Type: Article

References (32)

1. Dickman R., Fass R. Functional heartburn. Curr Treat Options Gastroenterol 2005 8 : 285 91.
2. Fass R, Tougas G. Functional heartburn: the stimulus, the pain, and the brain. Gut 2002 51 : 885 92.
3. Quigley EM. Non-erosive reflux disease, functional heartburn and gastroesophageal reflux disease; insights into pathophysiology and clinical presentation. Chin J Dig Dis 2006 7 : 186 90.
4. Barlow WJ, Orlando RC. The pathogenesis of heartburn in nonerosive reflux disease: a unifying hypothesis. Gastroenterology 2005 128 : 771 8.
5. Drewes AM, Reddy H, Staahl C et al. Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid. World J Gastroenterol 2005 11 : 4367 74.
6. Fass R, Yalam JM, Camargo L, Johnson C, Garewal HS, Sampliner RE. Increased esophageal chemoreceptor sensitivity to acid in patients after successful reversal of Barrett's esophagus. Dig Dis Sci 1997 42 : 1853 8.
7. Pedersen J, Reddy H, Funch-Jensen P, Arendt-Nielsen L, Gregersen H, Drewes AM. Cold and heat pain assessment of the human oesophagus after experimental sensitisation with acid. Pain 2004 110 : 393 9.
8. Sarkar S, Aziz Q, Woolf CJ, Hobson AR, Thompson DG. Contribution of central sensitisation to the development of non-cardiac chest pain. Lancet 2000 356 : 1154 9.
9. Sarkar S, Hobson AR, Furlong PL, Woolf CJ, Thompson DG, Aziz Q. Central neural mechanisms mediating human visceral hypersensitivity. Am J Physiol Gastrointest Liver Physiol 2001 281 : G1196 202.
10. Sarkar S, Woolf CJ, Hobson AR, Thompson DG, Aziz Q. Perceptual wind-up in the human oesophagus is enhanced by central sensitisation. Gut 2006 55 : 920 5.
11. Sarkar S, Thompson DG, Woolf CJ, Hobson AR, Millane T, Aziz Q. Patients with chest pain and occult gastroesophageal reflux demonstrate visceral pain hypersensitivity which may be partially responsive to acid suppression. Am J Gastroenterol 2004 99 : 1998 2006.
12. Drewes AM, Schipper KP, Dimcevski G et al. Multi-modal induction and assessment of allodynia and hyperalgesia in the human oesophagus. Eur J Pain 2003 7 : 539 49.
13. Hobson AR, Aziz Q, Furlong PL, Barlow JD, Bancewicz J, Thompson DG. Identification of the optimal parameters for recording cortical evoked potentials to human oesophageal electrical stimulation. Neurogastroenterol Motil 1998 10 : 421 30.
14. Hobson AR, Sarkar S, Furlong PL, Thompson DG, Aziz Q. A cortical evoked potential study of afferents mediating human esophageal sensation. Am J Physiol Gastrointest Liver Physiol 2000 279 : G139 47.
15. Hobson AR, Furlong PL, Worthen SF et al. Real-time imaging of human cortical activity evoked by painful esophageal stimulation. Gastroenterology 2005 128 : 610 9.
16. DeMeester TR, Wang CI, Wernly JA et al. Technique, indications, and clinical use of 24 hour esophageal pH monitoring. J Thorac Cardiovasc Surg 1980 79 : 656 70.
17. Fass R, Shapiro M, Dekel R, Sewell J. Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease - where next? Aliment Pharmacol Ther 2005 22 : 79 94.
18. Tack J, Fass R. Review article: approaches to endoscopic-negative reflux disease: part of the GERD spectrum or a unique acid-related disorder? Aliment Pharmacol Ther 2004 19 (Suppl. 1 28 34.
19. Sami SA, Rossel P, Dimcevski G et al. Cortical changes to experimental sensitization of the human esophagus. Neuroscience 2006 140 : 269 79.
20. Sarkar S, Hobson AR, Hughes A et al. The prostaglandin E2 receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans. Gastroenterology 2003 124 : 18 25.
21. Willert RP, Woolf CJ, Hobson AR, Delaney C, Thompson DG, Aziz Q. The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-d-aspartate receptor. Gastroenterology 2004 126 : 683 92.
22. Willert RP, Hobson AR, Delaney C, Hicks KJ, Dewit OE, Aziz Q. Neurokinin-1 receptor antagonism in a human model of visceral hypersensitivity. Aliment Pharmacol Ther 2007 25 : 309 16.
23. Willert RP, Delaney C, Hobson AR, Thompson DG, Woolf CJ, Aziz Q. Constitutive cyclo-oxygenase-2 does not contribute to the development of human visceral pain hypersensitivity. Eur J Pain 2006 10 : 487 94.
24. Aziz Q. Acid sensors in the gut: a taste of things to come. Eur J Gastroenterol Hepatol 2001 13 : 885 8.
25. Dickman R, Pasricha PJ, Winston J, Shenoy M, Hernandez D, Fass R. Patients with non-erosive reflux disease (NERD) demonstrate upregulation of TRPV1 receptors in the distal esophagus as compared to the other GERD groups. Gastroenterology 2006 130 : A-392, M2002.
26. Matthews PJ, Aziz Q, Facer P, Davis JB, Thompson DG, Anand P. Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human oesophagus. Eur J Gastroenterol Hepatol 2004 16 : 897 902.
27. Bhat YM, Bielefeldt K. Capsaicin receptor (TRPV1) and non-erosive reflux disease. Eur J Gastroenterol Hepatol 2006 18 : 263 70.
28. Trimble KC, Pryde A, Heading RC. Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD. Gut 1995 37 : 7 12.
29. Reddy H, Staahl C, Arendt-Nielsen L, Gregersen H, Drewes AM, Funch-Jensen P. Sensory and biomechanical properties of the esophagus in non-erosive reflux disease. Scand J Gastroenterol 2007 42 : 432 40.
30. Kern MK, Birn RM, Jaradeh S et al. Identification and characterization of cerebral cortical response to esophageal mucosal acid exposure and distention. Gastroenterology 1998 115 : 1353 62.
31. Hobson AR, Furlong PL, Sarkar S et al. Neurophysiologic assessment of esophageal sensory processing in noncardiac chest pain. Gastroenterology 2006 130 : 80 8.
32. Yang M, Li ZS, Xu XR et al. Characterization of cortical potentials evoked by oesophageal balloon distention and acid perfusion in patients with functional heartburn. Neurogastroenterol Motil 2006 18 : 292 9.