μ-calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptosis

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Valero, Juan García ^a   Cornut Thibaut, Aurélie ^b   Jugé, Romain ^b   Debaud, Anne Laure ^a   Giménez, Diana ^c   Gillet, Germain ^d   Bonnefoy Bérard, Nathalie ^a   Salgado, Jesús ^c   Salles, Gilles ^b   Aouacheria, Abdel ^b   Kucharczak, Jérôme ^b  

^a UNIVERSITÉ LYON 1   (France)

^b UNIVERSITÉ DE LYON   (France)

^c UNIVERSITY OF VALENCIA   (Spain)

^d CENTRE LÉON BÉRARD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BCL2 RELATED PROTEIN A1; BIOLOGICAL FACTOR; CALPAIN 1; CYTOCHROME C; PRODEATH FACTOR; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ALPHA HELIX; ANIMAL CELL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CLEARANCE; CONTROLLED STUDY; EMBRYO; GENETIC TRANSFECTION; MEMBRANE STABILIZATION; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; THREE DIMENSIONAL IMAGING; TUMOR CELL CLEARANCE;

ANIMALS; APOPTOSIS; CALPAIN; CELL LINE, TUMOR; CYTOCHROMES C; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; MICE; MICROSCOPY, CONFOCAL; MITOCHONDRIA; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84862667284     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038620     Document Type: Article

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