Urinary copper elevation in a mouse model of Wilson's disease is a regulated process to specifically decrease the hepatic copper load

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Gray, Lawrence W ^a   Peng, Fangyu ^b   Molloy, Shannon A ^c   Pendyala, Venkata S ^a   Muchenditsi, Abigael ^a   Muzik, Otto ^d   Lee, Jaekwon ^e   Kaplan, Jack H ^c   Lutsenko, Svetlana ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; COPPER; PROTEIN CTR1; SMALL COPPER CARRIER PROTEIN; UNCLASSIFIED DRUG;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BIOACCUMULATION; CELL DEATH; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; COPPER BLOOD LEVEL; COPPER METABOLISM; COPPER URINE LEVEL; DISEASE SEVERITY; DOWN REGULATION; HUMAN; HUMAN CELL; LIVER METABOLISM; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PROTEIN URINE LEVEL; TISSUE SPECIFICITY; URINE LEVEL; WILSON DISEASE;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BILE; CATION TRANSPORT PROTEINS; COPPER; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HEK293 CELLS; HEPATOLENTICULAR DEGENERATION; HOMEOSTASIS; HUMANS; KIDNEY; LIVER; LONGITUDINAL STUDIES; MICE; MICE, KNOCKOUT; UP-REGULATION;

EID: 84862649408     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038327     Document Type: Article

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