Clinical chemistry of human FcRn transgenic mice

Mammalian Genome

Volumn 23, Issue 3-4, 2012, Pages 259-269

  Stein, Carsten ^a,b   Kling, Lothar ^a   Proetzel, Gabriele ^c   Roopenian, Derry C ^c   De Angelis, Martin Hrabě ^d,e   Wolf, Eckhard ^b   Rathkolb, Birgit ^b,d  

^a ROCHE DIAGNOSTICS GMBH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c JACKSON LABORATORY   (United States)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; FC RECEPTOR; IMMUNOGLOBULIN G;

ALBUMIN BLOOD LEVEL; ARTICLE; C57BL 6 MOUSE; CLINICAL CHEMISTRY; CONTROLLED STUDY; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FUNCTION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; STRAIN DIFFERENCE; TRANSGENIC MOUSE; WILD TYPE;

ALBUMINS; ANIMALS; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNOGLOBULIN G; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, FC;

MURINAE; MUS; MUS MUSCULUS; RATTUS;

EID: 84862638874     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-011-9379-6     Document Type: Article

References (73)

1. Andersen JT, Daba MB, Berntzen G, Michaelsen TE, Sandlie I (2010) Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding. J Biol Chem 285:4826-4836
2. Ando S, Kon K, Tanaka Y, Nagase S, Nagai Y (1980) Characterization of hyperlipidemia in Nagase analbuminemia rat (NAR). J Biochem 87:1859-1862 (Pubitemid 10028368)
3. Avery RA, Alpert E, Weigand K, Dugaiczyk A (1983) Structural integrity of the human albumin gene in congenital analbuminemia. Biochem Biophys Res Commun 116:817-821 (Pubitemid 14202666)
4. Baldo G, Fellin R, Manzato E, Baiocchi MR, Ongaro G, Baggio G, Fabiani F, Pauluzzi S, Crepaldi G (1983) Characterization of hyperlipidemia in two patients with analbuminemia. Clin Chim Acta 128:307-319 (Pubitemid 13110843)
5. Baldo-Enzi G, Baiocchi MR, Vigna G, Andrian C, Mosconi C, Fellin R (1987) Analbuminaemia: a natural model of metabolic compensatory systems. J Inherit Metab Dis 10:317-329
6. Ballmer PE (2001) Causes and mechanisms of hypoalbuminaemia. Clin Nutr 20:271-273
7. Braschi S, Lagrost L, Florentin E, Martin C, Athias A, Gambert P, Krempf M, Lallemant C, Jacotot B (1996) Increased cholesteryl ester transfer activity in plasma from analbuminemic patients. Arterioscler Thromb Vasc Biol 16:441-449 (Pubitemid 26084319)
8. Burgess LJ, Marais AD (2001) The use of simvastatin in analbuminaemia. Cardiovasc Drugs Ther 15:555-558 (Pubitemid 34163943)
9. Campagnoli M, Rossi A, Palmqvist L, Flisberg A, Niklasson A, Minchotti L, Galliano M (2002) A novel splicing mutation causes an undescribed type of analbuminemia. Biochim Biophys Acta 1586:43-49 (Pubitemid 34066615)
10. Campagnoli M, Sala A, Labo S, Rossi A, Neuhaus TJ, Braegger CP, Minchiotti L, Galliano M (2005) Analbuminemia in a Swiss family is caused by a C ? T transition at nucleotide 4446 of the albumin gene. Clin Biochem 38:819-823 (Pubitemid 41097489)
11. Campagnoli M, Rosipal S, Debreova M, Rosipal R, Sala A, Romano A, Labo S, Galliano M, Minchiotti L (2006) Analbuminemia in a Slovak Romany (gypsy) family: case report and mutational analysis. Clin Chim Acta 365:188-193 (Pubitemid 43196437)
12. Campagnoli M, Hansson P, Dolcini L, Caridi G, Dagnino M, Candiano G, Bruschi M, Palmqvist L, Galliano M, Minchiotti L (2008) Analbuminemia in a Swedish male is caused by the Kayseri mutation (c228-229delAT). Clin Chim Acta 396:89-92
13. Catanozzi S, Rocha JC, Nakandakare ER, Oliveira HC, Quintao EC (1994) Nagase analbuminemic rats have faster plasma triacylglycerol and VLDL synthesis rates. Biochim Biophys Acta 1212:103-108 (Pubitemid 24123893)
14. Champy MF, Selloum M, Zeitler V, Caradec C, Jung B, Rousseau S, Pouilly L, Sorg T, Auwerx J (2008) Genetic background determines metabolic phenotypes in the mouse. Mamm Genome 19:318-331
15. Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, Anderson CL (2003) The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 197:315-322 (Pubitemid 36184238)
16. Cormode EJ, Lyster DM, Israels S (1975) Analbuminemia in a neonate. J Pediatr 86:862-867
17. Dammacco F, Miglietta A, D'Addabbo A, Fratello A, Moschetta R, Bonomo L (1980) Analbuminemia: report of a case and review of the literature. Vox Sang 39:153-161 (Pubitemid 11210046)
18. Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Jiang W, Wroblewski VJ (2007a) Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates. Drug Metab Dispos 35:86-94 (Pubitemid 46036480)
19. Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Wroblewski VJ (2007b) Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor. J Biol Chem 282:1709-1717 (Pubitemid 47076691)
20. Emori T, Takahashi M, Sugiyama K, Shumiya S, Nagase S (1983) Age-related changes in plasma proteins of analbuminemic rats. Jikken Dobutsu 32:123-132
21. Esumi H, Sato S, Takahashi Y, Nagase S, Sugimura T (1982a) A seven base pair deletion in an intron blocks albumin mRNA processing. Princess Takamatsu Symp 12:87-100
22. Esumi H, Takahashi Y, Sekiya T, Sato S, Nagase S, Sugimura T (1982b) Presence of albumin mRNA precursors in nuclei of analbuminemic rat liver lacking cytoplasmic albumin mRNA. Proc Natl Acad Sci USA 79:734-738 (Pubitemid 12160306)
23. Frohlich J, Pudek MR, Cormode EJ, Sellers EM, Abel JG (1981) Further studies on plasma proteins, lipids, and dye- and drugbinding in a child with analbuminemia. Clin Chem 27:1213-1216 (Pubitemid 11071862)
24. Gailus-Durner V, Fuchs H, Adler T, Aguilar PA, Becker L, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Ferwagner B, Hans W, Holter SM, Holzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Morth C, Mossbrugger I, Naton B, Prehn C, Puk O, Rathkolb B, Rozman J, Schrewe A, Thiele F, Adamski J, Aigner B, Behrendt H, Busch DH, Favor J, Graw J, Heldmaier G, Ivandic B, Katus H, Klingenspor M, Klopstock T, Kremmer E, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, de Angelis MH (2009) Systemic first-line phenotyping. Methods Mol Biol 530:463-509
25. Galliano M, Campagnoli M, Rossi A, Wirsing von Konig CH, Lyon AW, Cefle K, Yildiz A, Palanduz S, Ozturk S, Minchiotti L (2002) Molecular diagnosis of analbuminemia: a novel mutation identified in two Amerindian and two Turkish families. Clin Chem 48:844-849 (Pubitemid 34587583)
26. Gambino R, Desvarieux E, Orth M, Matan H, Ackattupathil T, Lijoi E, Wimmer C, Bower J, Gunter E (1997) The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferrin concentrations in human serum. Clin Chem 43:2408-2412 (Pubitemid 28022980)
27. Gomez JL, Gunnerson KJ, Song M, Li J, Kellum JA (2007) Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats. Chest 131:1295-1300 (Pubitemid 46762331)
28. Hinton PR, Xiong JM, Johlfs MG, Tang MT, Keller S, Tsurushita N (2006) An engineered human IgG1 antibody with longer serum half-life. J Immunol 176:346-356 (Pubitemid 43023280)
29. Inaba M, Morii H, Katsumata T, Goto H, Ishimura E, Kawagishi T, Kamao M, Okano T, Nishizawa Y (2000) Hyperparathyroidism is augmented by ovariectomy in Nagase analbuminemic rats. J Nutr 130:1543-1547 (Pubitemid 30340700)
30. Joles JA, Willekes-Koolschijn N, Van Tol A, Geelhoed-Mieras MM, Danse LH, Van GE, Kortlandt W, Erkelens DW, Koomans HA (1991) Hyperlipoproteinemia in one-year-old analbuminemic rats. Atherosclerosis 88:35-47
31. Kallee E (1996) Bennhold's analbuminemia: a follow-up study of the first two cases (1953-1992). J Lab Clin Med 127:470-480
32. Kaysen GA (1988) Albumin metabolism in the nephrotic syndrome: the effect of dietary protein intake. Am J Kidney Dis 12:461-480
33. Kaysen GA (1993) Plasma composition in the nephrotic syndrome. Am J Nephrol 13:347-359
34. Kikuchi H, Tamura S, Nagase S, Tsuiki S (1983) Hypertriacylglycerolemia and adipose tissue lipoprotein lipase activity in the Nagase analbuminemic rat. Biochim Biophys Acta 744:165-170 (Pubitemid 13056258)
35. Kim EJ, Lee AK, Kim SH, Kim SG, Lee MG (2003) Pharmacokinetics and pharmacodynamics of intravenous azosemide in mutant Nagase analbuminemic rats. Drug Metab Dispos 31:194-201 (Pubitemid 36159611)
36. Kim J, Bronson CL, Hayton WL, Radmacher MD, Roopenian DC, Robinson JM, Anderson CL (2006) Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces. Am J Physiol Gastrointest Liver Physiol 290:G352-G360
37. Klempt M, Rathkolb B, Fuchs E, de Angelis MH, Wolf E, Aigner B (2006) Genotype-specific environmental impact on the variance of blood values in inbred and F1 hybrid mice. Mamm Genome 17:93-102 (Pubitemid 43209148)
38. Koot BG, Houwen R, Pot DJ, Nauta J (2004) Congenital analbuminaemia: biochemical and clinical implications. A case report and literature review. Eur J Pediatr 163:664-670 (Pubitemid 39517891)
39. Kuo TT, de Muinck EJ, Claypool SM, Yoshida M, Nagaishi T, Aveson VG, Lencer WI, Blumberg RS (2009) N-glycan moieties in neonatal Fc receptor determine steady-state membrane distribution and directional transport of IgG. J Biol Chem 284:8292-8300
40. Ladenson JH, Lewis JW, McDonald JM, Slatopolsky E, Boyd JC (1979) Relationship of free and total calcium in hypercalcemic conditions. J Clin Endocrinol Metab 48:393-397 (Pubitemid 9140779)
41. MacKenzie PI, Messer M (1976) Studies on the origin and excretion of serum alpha-amylase in the mouse. Comp Biochem Physiol B 54:103-106
42. Maugeais C, Braschi S, Ouguerram K, Maugeais P, Mahot P, Jacotot B, Darmaun D, Magot T, Krempf M (1997) Lipoprotein kinetics in patients with analbuminemia. Evidence for the role of serum albumin in controlling lipoprotein metabolism. Arterioscler Thromb Vasc Biol 17:1369-1375 (Pubitemid 27329862)
43. Montoyo HP, Vaccaro C, Hafner M, Ober RJ, Mueller W, Ward ES (2009) Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice. Proc Natl Acad Sci USA 106(8):2788-2793
44. Nagase S, Shimamune K, Shumiya S (1979) Albumin-deficient rat mutant. Science 205:590-591 (Pubitemid 9239302)
45. Nagase S, Shimamune K, Shumiya S (1980) Albumin-deficient rat mutant: an animal model for analbuminemia. Jikken Dobutsu 29:33-38 (Pubitemid 10185799)
46. Nicklas W, Baneux P, Boot R, Decelle T, Deeny AA, Fumanelli M, Illgen-Wilcke B (2002) Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units. Lab Anim 36:20-42 (Pubitemid 34073119)
47. Ober RJ, Radu CG, Ghetie V, Ward ES (2001) Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. Int Immunol 13:1551-1559 (Pubitemid 33133882)
48. Ochrietor JD, Harrison KA, Zahedi K, Mortensen RF (2000) Role of STAT3 and C/EBP in cytokine-dependent expression of the mouse serum amyloid P-component (SAP) and C-reactive protein (CRP) genes. Cytokine 12:888-899 (Pubitemid 30479470)
49. Payne RB, Little AJ, Williams RB, Milner JR (1973) Interpretation of serum calcium in patients with abnormal serum proteins. Br Med J 4:643-646
50. Payne RB, Carver ME, Morgan DB (1979) Interpretation of serum total calcium: effects of adjustment for albumin concentration on frequency of abnormal values and on detection of change in the individual. J Clin Pathol 32:56-60 (Pubitemid 9108607)
51. Peters T (1996) All about albumin: biochemistry, genetics, and medical applications. Academic Press, San Diego
52. Peterson J, Bengtsson-Olivecrona G, Olivecrona T (1986) Mouse preheparin plasma contains high levels of hepatic lipase with low affinity for heparin. Biochim Biophys Acta 878:65-70 (Pubitemid 16049130)
53. Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al KH, Brown AC, Presta LG, Meng YG, Roopenian DC (2006) Enhanced halflife of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 18:1759-1769 (Pubitemid 44884038)
54. Prinsen BH, Kaysen GA, Klomp LW, De BJ, Barrett PH, Thornalley PJ, Battah S, Berger R, Rabelink TJ, der Velden MG (2002) Idiopathic hypoalbuminemia explained by reduced synthesis rate and an increased catabolic rate. Clin Biochem 35:545-553 (Pubitemid 35462130)
55. Rathkolb B, Decker T, Fuchs E, Soewarto D, Fella C, Heffner S, Pargent W, Wanke R, Balling R, de Hrabe AM, Kolb HJ, Wolf E (2000) The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes. Mamm.Genome 11:543-546 (Pubitemid 30602221)
56. Roopenian DC, Akilesh S (2007) FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 7:715-725 (Pubitemid 47327396)
57. Roopenian DC, Christianson GJ, Sproule TJ, Brown AC, Akilesh S, Jung N, Petkova S, Avanessian L, Choi EY, Shaffer DJ, Eden PA, Anderson CL (2003) The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol 170:3528-3533 (Pubitemid 36359219)
58. Roopenian DC, Christianson GJ, Sproule TJ (2010) Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies. Methods Mol Biol 602:93-104
59. Ruot B, Breuille D, Rambourdin F, Bayle G, Capitan P, Obled C (2000) Synthesis rate of plasma albumin is a good indicator of liver albumin synthesis in sepsis. Am J Physiol Endocrinol Metab 279:E244-E251
60. Shin Y, Vaziri ND, Willekes N, Kim CH, Joles JA (2005) Effects of gender on hepatic HMG-CoA reductase, cholesterol 7alphahydroxylase, and LDL receptor in hereditary analbuminemia. Am J Physiol Endocrinol Metab 289:E993-E998 (Pubitemid 43671048)
61. Sierra F, Pittet AC, Schibler U (1986) Different tissue-specific expression of the amylase gene Amy-1 in mice and rats. Mol Cell Biol 6:4067-4076
62. Sugiyama K, Emori T, Shumiya S, Nagase S (1984) Anemia and potassium permeability of red blood cells in analbuminemic rats. Jikken Dobutsu 33:307-318
63. Sun X, Kaysen GA (1994) Albumin and transferrin synthesis are increased in H4 cells by serum from analbuminemic or nephrotic rats. Kidney Int 45(5):1381-1387 (Pubitemid 24135024)
64. Sun X, Jones H Jr., Joles JA, van TA, Kaysen GA (1992) Apolipoprotein gene expression in analbuminemic rats and in rats with Heymann nephritis. Am J Physiol 262:F755-F761
65. Takahashi M, Kusumi K, Shumiya S, Nagase S (1983) Plasma lipid concentrations and enzyme activities in Nagase analbuminemia rats (NAR). Jikken Dobutsu 32:39-46
66. Vaccaro C, Bawdon R, Wanjie S, Ober RJ, Ward ES (2006) Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies. Proc Natl Acad Sci USA 103:18709-18714 (Pubitemid 44913475)
67. Van Tol A, Jansen EH, Koomans HA, Joles JA (1991) Hyperlipoproteinemia in Nagase analbuminemic rats: effects of pravastatin on plasma (apo)lipoproteins and lecithin:cholesterol acyltransferase activity. J Lipid Res 32:1719-1728
68. Vusse GJ (2009) Albumin as fatty acid transporter. Drug Metab Pharmacokinet 24:300-307
69. Waldmann TA (1972) Protein-losing enteropathy and kinetic studies of plasma protein metabolism. Semin Nucl Med 2:251-263
70. Wang W, Vlasak J, Li Y, Pristatsky P, Fang Y, Pittman T, Roman J, Wang Y, Prueksaritanont T, Ionescu R (2011) Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies. Mol Immunol 48:860-866
71. Ward ES, Ober RJ (2009) Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn. Adv Immunol 103:77-115
72. Zalevsky J, Chamberlain AK, Horton HM, Karki S, Leung IW, Sproule TJ, Lazar GA, Roopenian DC, Desjarlais JR (2010) Enhanced antibody half-life improves in vivo activity. Nat Biotechnol 28:157-159
73. Zhou X, Hansson GK (2004) Effect of sex and age on serum biochemical reference ranges in C57BL/6J mice. Comp Med 54:176-178 (Pubitemid 38590833)