The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: Screening for clinically relevant phenotypes

Mammalian Genome

Volumn 11, Issue 7, 2000, Pages 543-546

  Rathkolb, Birgit ^a   Decker, Tanja ^a   Fuchs, Edith ^b   Soewarto, Dian ^c   Fella, Christiane ^c   Heffner, Stephan ^c   Pargent, Walter ^c   Wanke, Rüdiger ^a   Balling, Rudi ^c   Hrabé De Angelis, Martin ^c   Kolb, Helmut J ^b   Wolf, Eckhard ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b City Hospital Munich Harlaching   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHM; ARTICLE; DIAGNOSTIC PROCEDURE; DIAGNOSTIC VALUE; GENETIC SCREENING; GLUCOSE METABOLISM; KIDNEY DISEASE; MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; PROGENY;

ANIMALS; BIOLOGICAL MARKERS; CLINICAL CHEMISTRY TESTS; ETHYLNITROSOUREA; GENETIC SCREENING; HEMATOLOGIC TESTS; KIDNEY DISEASES; MICE; MUTAGENESIS; MUTAGENS; PHENOTYPE;

EID: 0033862572     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003350010104     Document Type: Article

References (14)

1. Bocskei Z, Groom CR, Flower DR, Wright CE, Phillips SE et al. (1992) Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography. Nature 360, 186-188
2. Brazeau GA, Mathew M, Entrikin RK (1992) Serum and organ indices of the mdx dystrophic mouse. Res Commun Chem Pathol Pharmacol 77, 179-189
3. Doi T, Striker LJ, Gibson CC, Agodoa LYC, Brinster RL et al. (1990) Glomerular lesions in mice transgenic for growth hormone and insulin-like growth factor-I. I. Relationship between increased glomerular size and mesangial sclerosis. Am J Pathol 137, 541-552
4. nd ed. (Heidelberg, New York: Springer-Verlag)
5. Foreman JW, Chan JCM (1988) Chronic renal failure in infants and children. J Pediatr 113, 793-800
6. Gerich JE (1998) The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev 19, 491-503
7. Hrabé de Angelis M, Balling R (1998) Large scale ENU screens in the mouse. Genetics meets genomics. Mutat Res 400, 25-32
8. Levey AS, Perrone RD, Madias NE (1988) Serum creatinine and renal function. Annu Rev Med 39, 465-490
9. Pelegrin M, Devedjian JC, Costa C, Visa J, Solanes G, et al. (1998) Evidence from transgenic mice that interferon-beta may be involved in the onset of diabetes mellitus. J Biol Chem 273, 12332-12340
10. Saborio P, Scheinman J (1998) Genetic renal disease. Curr Opin Pediatr 70, 174-183
11. Saudubray JM, Charpentier C (1995) Clinical phenotypes: diagnosis/ algorithms. InThe Metabolic and Molecular Bases of Inherited Disease, Vol I. C Scriver et al., eds, 7th edn. (New York: McGraw-Hill, Inc.) pp 327-400
12. Wolf E, Wanke R (1997) Growth hormone overproduction in transgenic mice: phenotypic alterations and deduced animal models. In Welfare of Transgenic Animals, LFM van Zutphen, M van der Meer, eds. (Heidelberg: Springer-Verlag), pp 26-47
13. Wolf E, Kramer R, Blum WF, Föll J, Brem G (1994) Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth. Endocrinology 135, 1877-1886
14. Wu X, Wakamiya M, Vaishnav S, Geske R, Montgomer C Jr et al. (1994) Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. Proc Natl Acad Sci USA 91, 742-746