Identification of TLT2 as an engulfment receptor for apoptotic cells

Journal of Immunology

Volumn 188, Issue 12, 2012, Pages 6381-6388

  De Freitas, Andressa ^a   Banerjee, Sami ^a   Xie, Na ^a   Cui, Huachun ^a   Davis, Kasey I ^b   Friggeri, Arnaud ^c,d   Fu, Mingui ^e   Abraham, Edward ^f   Liu, Gang ^a  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c AMIENS UNIVERSITY HOSPITAL   (France)

^d INSERM   (France)

^e UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^f WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 9; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNE RESPONSE; IMMUNE SYSTEM; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PATHOGEN CLEARANCE; PHAGOCYTOSIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; THYMOCYTE;

ANIMALS; APOPTOSIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNITY, INNATE; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHAGOCYTOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3;

EID: 84862631995     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1200020     Document Type: Article

References (34)

1. Elliott, M. R., and K. S. Ravichandran. 2010. Clearance of apoptotic cells: implications in health and disease. J. Cell Biol. 189: 1059-1070.
2. Park, D., A. C. Tosello-Trampont, M. R. Elliott, M. Lu, L. B. Haney, Z. Ma, A. L. Klibanov, J. W. Mandell, and K. S. Ravichandran. 2007. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature 450: 430-434. (Pubitemid 350126756)
3. Miyanishi, M., K. Tada, M. Koike, Y. Uchiyama, T. Kitamura, and S. Nagata. 2007. Identification of Tim4 as a phosphatidylserine receptor. Nature 450: 435-439. (Pubitemid 350126753)
4. Friggeri, A., S. Banerjee, S. Biswas, A. de Freitas, G. Liu, A. Bierhaus, and E. Abraham. 2011. Participation of the receptor for advanced glycation end products in efferocytosis. J. Immunol. 186: 6191-6198.
5. Park, S. Y., M. Y. Jung, S. J. Lee, K. B. Kang, A. Gratchev, V. Riabov, J. Kzhyshkowska, and I. S. Kim. 2009. Stabilin-1 mediates phosphatidylserine- dependent clearance of cell corpses in alternatively activated macrophages. J. Cell Sci. 122: 3365-3373.
6. Kawai, T., and S. Akira. 2010. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11: 373-384.
7. Klesney-Tait, J., I. R. Turnbull, and M. Colonna. 2006. The TREM receptor family and signal integration. Nat. Immunol. 7: 1266-1273. (Pubitemid 46111244)
8. Ford, J. W., and D. W. McVicar. 2009. TREM and TREM-like receptors in inflammation and disease. Curr. Opin. Immunol. 21: 38-46.
9. Westcott, M. M., C. J. Henry, A. S. Cook, K. W. Grant, and E. M. Hiltbold. 2007. Differential susceptibility of bone marrow-derived dendritic cells and macrophages to productive infection with Listeria monocytogenes. Cell. Microbiol. 9: 1397-1411. (Pubitemid 46774013)
10. Wan, M., X. Shi, X. Feng, and X. Cao. 2001. Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression. J. Biol. Chem. 276: 10119-10125.
11. Hanayama, R., M. Tanaka, K. Miwa, A. Shinohara, A. Iwamatsu, and S. Nagata. 2002. Identification of a factor that links apoptotic cells to phagocytes. Nature 417: 182-187. (Pubitemid 34506799)
12. Rodriguez-Manzanet, R., M. A. Sanjuan, H. Y. Wu, F. J. Quintana, S. Xiao, A. C. Anderson, H. L. Weiner, D. R. Green, and V. K. Kuchroo. 2010. T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc. Natl. Acad. Sci. USA 107: 8706-8711.
13. Liu, G., A. Friggeri, Y. Yang, Y. J. Park, Y. Tsuruta, and E. Abraham. 2009. miR- 147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. Proc. Natl. Acad. Sci. USA 106: 15819-15824.
14. Liu, G., A. Friggeri, Y. Yang, J. Milosevic, Q. Ding, V. J. Thannickal, N. Kaminski, and E. Abraham. 2010. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J. Exp. Med. 207: 1589-1597.
15. Hanayama, R., K. Miyasaka, M. Nakaya, and S. Nagata. 2006. MFG-E8- dependent clearance of apoptotic cells, and autoimmunity caused by its failure. Curr. Dir. Autoimmun. 9: 162-172.
16. Wu, Y., N. Tibrewal, and R. B. Birge. 2006. Phosphatidylserine recognition by phagocytes: a view to a kill. Trends Cell Biol. 16: 189-197.
17. Gardai, S. J., K. A. McPhillips, S. C. Frasch, W. J. Janssen, A. Starefeldt, J. E. Murphy-Ullrich, D. L. Bratton, P. A. Oldenborg, M. Michalak, and P. M. Henson. 2005. Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 123: 321-334. (Pubitemid 41457220)
18. Yoon, H. J., S. B. Jeon, I. H. Kim, and E. J. Park. 2008. Regulation of TLR2 expression by prostaglandins in brain glia. J. Immunol. 180: 8400-8409.
19. Perry, A. K., G. Chen, D. Zheng, H. Tang, and G. Cheng. 2005. The host type I interferon response to viral and bacterial infections. Cell Res. 15: 407-422. (Pubitemid 41642869)
20. King, R. G., B. R. Herrin, and L. B. Justement. 2006. Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is upregulated in response to inflammation. J. Immunol. 176: 6012-6021.
21. Park, S. Y., M. Y. Jung, H. J. Kim, S. J. Lee, S. Y. Kim, B. H. Lee, T. H. Kwon, R. W. Park, and I. S. Kim. 2008. Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Cell Death Differ. 15: 192-201.
22. Munoz, L. E., B. Frey, F. Pausch, W. Baum, R. B. Mueller, B. Brachvogel, E. Poschl, F. Rödel, K. von der Mark, M. Herrmann, and U. S. Gaipl. 2007. The role of annexin A5 in the modulation of the immune response against dying and dead cells. Curr. Med. Chem. 14: 271-277.
23. Ravichandran, K. S., and U. Lorenz. 2007. Engulfment of apoptotic cells: signals for a good meal. Nat. Rev. Immunol. 7: 964-974. (Pubitemid 350166061)
24. Baumann, I., W. Kolowos, R. E. Voll, B. Manger, U. Gaipl, W. L. Neuhuber, T. Kirchner, J. R. Kalden, and M. Herrmann. 2002. Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum. 46: 191-201. (Pubitemid 34121664)
25. Hanayama, R., M. Tanaka, K. Miyasaka, K. Aozasa, M. Koike, Y. Uchiyama, and S. Nagata. 2004. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 304: 1147-1150. (Pubitemid 38661849)
26. Tas, S. W., P. Quartier, M. Botto, and L. Fossati-Jimack. 2006. Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells. Ann. Rheum. Dis. 65: 216-221. (Pubitemid 43131996)
27. Fujimoto, I., J. Pan, T. Takizawa, and Y. Nakanishi. 2000. Virus clearance through apoptosis-dependent phagocytosis of influenza A virus-infected cells by macrophages. J. Virol. 74: 3399-3403. (Pubitemid 30143765)
28. Hiscott, J. 2007. Triggering the innate antiviral response through IRF-3 activation. J. Biol. Chem. 282: 15325-15329. (Pubitemid 47093257)
29. Haslett, C. 1999. Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am. J. Respir. Crit. Care Med. 160: S5-S11.
30. Hashiguchi, M., H. Kobori, P. Ritprajak, Y. Kamimura, H. Kozono, and M. Azuma. 2008. Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses. Proc. Natl. Acad. Sci. USA 105: 10495-10500.
31. Gibot, S., M. N. Kolopp-Sarda, M. C. Béné, P. E. Bollaert, A. Lozniewski, F. Mory, B. Levy, and G. C. Faure. 2004. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J. Exp. Med. 200: 1419-1426. (Pubitemid 39657289)
32. Piccio, L., C. Buonsanti, M. Cella, I. Tassi, R. E. Schmidt, C. Fenoglio, J. Rinker, II, R. T. Naismith, P. Panina-Bordignon, N. Passini, et al. 2008. Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation. Brain 131: 3081-3091.
33. Jung, Y. S., S. W. Kim, J. Y. Yoon, J. H. Lee, S. M. Jeon, S. P. Hong, T. I. Kim, W. H. Kim, and J. H. Cheon. 2011. Expression of a soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) correlates with clinical disease activity in intestinal Behcet's disease. Inflamm. Bowel Dis. 17: 2130-2137.
34. Notley, C. A., M. A. Brown, G. P. Wright, and M. R. Ehrenstein. 2011. Natural IgM is required for suppression of inflammatory arthritis by apoptotic cells. J. Immunol. 186: 4967-4972.