DNA-dependent protein kinase (DNA-PK) inhibitors. synthesis and biological activity of quinolin-4-one and pyridopyrimidin-4-one surrogates for the chromen-4-one chemotype

Journal of Medicinal Chemistry

Volumn 53, Issue 24, 2010, Pages 8498-8507

  Cano, Céline ^a   Barbeau, Olivier R ^a   Bailey, Christine ^b   Cockcroft, Xiao Ling ^b   Curtin, Nicola J ^a   Duggan, Heather ^b   Frigerio, Mark ^b   Golding, Bernard T ^a   Hardcastle, Ian R ^a   Hummersone, Marc G ^b   Knights, Charlotte ^b   Menear, Keith A ^b   Newell, David R ^a   Richardson, Caroline J ^b   Smith, Graeme C M ^b   Spittle, Ben ^b   Griffin, Roger J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b KuDOS Pharmaceuticals Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLIN 4 YL N [4 (2 MORPHOLIN 4 YL 4 OXO 4H PYRIDO[1,2 A]PYRIMIDIN 9 YL)DIBENZOTHIOPHEN 1 YL]ACETAMIDE; AMINE; CHROMENE DERIVATIVE; DIBENZOFURAN DERIVATIVE; DNA DEPENDENT PROTEIN KINASE; HETEROCYCLIC COMPOUND; MORPHOLINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CROSS COUPLING REACTION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; SUZUKI MIYAURA CROSS COUPLINGI;

BENZOPYRANS; CELL MEMBRANE PERMEABILITY; DNA DAMAGE; DNA-ACTIVATED PROTEIN KINASE; FURANS; HELA CELLS; HUMANS; PYRIDINES; PYRIMIDINONES; QUINOLONES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 78650350366     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100608j     Document Type: Article

References (19)

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