Low fidelity bypass of O 2-(3-Pyridyl)-4-oxobutylthymine, the most persistent bulky adduct produced by the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Model DNA polymerases

Chemical Research in Toxicology

Volumn 25, Issue 6, 2012, Pages 1195-1202

  Gowda, A S Prakasha ^a   Krishnegowda, Gowdahalli ^a   Suo, Zucai ^b   Amin, Shantu ^a   Spratt, Thomas E ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; CARCINOGEN; DNA; DNA POLYMERASE; EXONUCLEASE; NITROSAMINE; O2 (3 PYRIDYL) 4 OXOBUTYLTHYMINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; DNA ADDUCT; DNA DAMAGE; DNA STRUCTURE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME KINETICS; MUTAGENESIS; SULFOLOBUS SOLFATARICUS; TOBACCO;

DNA; DNA POLYMERASE BETA; DNA POLYMERASE I; ESCHERICHIA COLI; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; NITROSAMINES; SULFOLOBUS SOLFATARICUS; THYMINE; TOBACCO;

EID: 84862579184     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200483g     Document Type: Article

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