Discovery of antimicrobial ribonucleotide reductase inhibitors by screening in microwell format

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 25, 2012, Pages 9798-9803

  Tholander, Fredrik ^a,b   Sjöberg, Britt Marie ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

High throughput assay; National Cancer Institute diversity set II; Nucleotide metabolism; Ribonucleotide reductase assay

Indexed keywords

CARBENICILLIN; DEOXYRIBONUCLEOTIDE; ENZYME INHIBITOR; HYDROXYUREA; NSC 228155; NSC 361666; RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDE REDUCTASE INHIBITOR; RUFOCROMOMYCIN; TETRACYCLINE; TOLONIUM CHLORIDE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONCENTRATION RESPONSE; DATA BASE; DRUG DEVELOPMENT; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; PSEUDOMONAS AERUGINOSA; RIBONUCLEOTIDE REDUCTASES;

EID: 84862560633     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1113051109     Document Type: Article

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