A novel class of cyclin-dependent kinase inhibitors identified by molecular docking act through a unique mechanism

Journal of Biological Chemistry

Volumn 284, Issue 43, 2009, Pages 29945-29955

  Corsino, Patrick ^a,b   Horenstein, Nicole ^c   Ostrov, David ^a,b   Rowe, Thomas ^a,b   Law, Mary ^a,b   Barrett, Amanda ^a   Aslanidi, George ^a   Cress, W Douglas ^d   Law, Brian ^a,b,e  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c University of Florida   (United States)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CDK INHIBITORS; CELL CYCLE; CELL-CYCLE ARREST; CONTROL PROCESS; CYCLIN-DEPENDENT KINASE; CYCLIN-DEPENDENT KINASE INHIBITORS; HIGH THROUGHPUT; IN-SILICO; MOLECULAR DOCKING; PRIMARY MECHANISM; PROTEIN AGGREGATION; PROTEIN LEVEL; SMALL MOLECULES; THERAPEUTIC TARGETS;

RUBIDIUM; TRANSCRIPTION;

CELL MEMBRANES;

1 (5 METHYLTHIOPHEN 2 YL) 3 PHENYLPROPENONE; 2 (4 METHOXYPHENYL) 3 PYRIDIN 2 YL ACRYLONITRILE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; NSC 117024; NSC 269621; NSC 43042; NSC 43067; NSC 63002; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE REGULATION; COMPUTER MODEL; CONTROLLED STUDY; CYTOSTASIS; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG MECHANISM; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION;

ADENOSINE TRIPHOSPHATE; CELL CYCLE; CELL LINE; CYCLIN-DEPENDENT KINASES; E2F TRANSCRIPTION FACTORS; ENZYME INDUCTION; HUMANS; PROTEIN KINASE INHIBITORS; RETINOBLASTOMA PROTEIN;

EID: 70350357186     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.055251     Document Type: Article

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