pfmdr1 amplification is related to increased Plasmodium falciparum in vitro sensitivity to the bisquinoline piperaquine

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 7, 2012, Pages 3615-3619

  Veiga, M I ^a,b,h   Ferreira, P E ^a,c   Malmberg, M ^a   Jornhagen L ^a   Bjorkman A ^a   Nosten, F ^d,e,f   Gil, J P ^a,c,g  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF MINHO   (Portugal)

^c UNIVERSITY OF ALGARVE   (Portugal)

^d SHOKLO MALARIA RESEARCH UNIT   (Thailand)

^e MAHIDOL UNIVERSITY   (Thailand)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g BINGHAMTON UNIVERSITY   (United States)

^h Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOQUINOLINE; BENFLUMETOL; CHLOROQUINE; DIHYDROARTEMISININ; MEFLOQUINE; MULTIDRUG RESISTANCE PROTEIN; PIPERAQUINE; PROTEIN PFMDR1; QUINOLINE; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ARTICLE; CHROMOSOME 5; CONTROLLED STUDY; COPY NUMBER VARIATION; DRUG EFFICACY; GENE AMPLIFICATION; GENE DUPLICATION; GENE IDENTIFICATION; GENE LOCUS; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; MYANMAR; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTOZOAL GENETICS; STATISTICAL SIGNIFICANCE; THAILAND;

ANTIMALARIALS; ATP-BINDING CASSETTE TRANSPORTERS; CHLOROQUINE; GENE DOSAGE; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; QUINOLINES;

EID: 84862538598     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.06350-11     Document Type: Article

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