Effects of tracheal orientation on development of ventilator-associated pneumonia: An experimental study

Intensive Care Medicine

Volumn 38, Issue 4, 2012, Pages 677-685

  Zanella, Alberto ^a,b   Cressoni, Massimo ^a,c,e   Epp, Myra ^a   Hoffmann, Viktoria ^d   Stylianou, Mario ^a   Kolobow, Theodor ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Artificial adverse effects; Intratracheal adverse effects Respiratory tract infections prevention and control Aspiration prevention and control; Intubation Postural drainage; Mechanical ventilation; Nosocomial infections; Pigs; Pneumonia Ventilator associated pneumonia Semirecumbent position; Pulmonary; Respiration

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; BACTERIAL COLONIZATION; ENDOTRACHEAL INTUBATION; ENDOTRACHEAL TUBE; ENTERIC FEEDING; EXPERIMENTAL PIG; EXPERIMENTAL STUDY; FEMALE; LUNG LOBE; MINIPIG; NONHUMAN; RESPIRATORY FAILURE; THORAX RADIOGRAPHY; TRACHEAL ORIENTATION; VENTILATOR ASSOCIATED PNEUMONIA;

ANIMALS; FEMALE; HEMODYNAMICS; INTUBATION, INTRATRACHEAL; PATIENT POSITIONING; PNEUMONIA, VENTILATOR-ASSOCIATED; RESPIRATION, ARTIFICIAL; STATISTICS, NONPARAMETRIC; SWINE; SWINE, MINIATURE; TRACHEA;

EID: 84862537702     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-012-2495-2     Document Type: Article

References (25)

1. Chastre J, Fagon JY (2002) Ventilatorassociated pneumonia. Am J Respir Crit Care Med 165:867-903
2. Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogue S, Ferrer M (1999) Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 354:1851-1858
3. Torres A, El-Ebiary M, Gonzalez J, Ferrer M, Puig de la Bellacasa J, Gene A, Martos A, Rodriguez-Roisin R (1993) Gastric and pharyngeal flora in nosocomial pneumonia acquired during mechanical ventilation. Am Rev Respir Dis 148:352-357
4. van Nieuwenhoven CA, Vandenbroucke-Grauls C, van Tiel FH, Joore HC, van Schijndel RJ, van der Tweel I, Ramsay, Bonten MJ (2006) Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med 34:396-402
5. Panigada M, Berra L, Greco G, Stylianou M, Kolobow T (2003) Bacterial colonization of the respiratory tract following tracheal intubationeffect of gravity: an experimental study. Crit Care Med 31:729-737
6. Stiletto RJ (2003) Bacterial colonization of the respiratory tract under artificial ventilation: is there proof of clinically relevant effects of the endotracheal tube orientation under positioning therapy? Crit Care Med 31:973-974
7. Luna CM, Sibila O, Agusti C, Torres A (2009) Animal models of ventilatorassociated pneumonia. Eur Respir J 33:182-188
8. Garrouste-Orgeas M, Chevret S, Arlet G, Marie O, Rouveau M, Popoff N, Schlemmer B (1997) Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients. a prospective study based on genomic DNA analysis. Am J Respir Crit Care Med 156:1647-1655
9. Torres A, Serra-Batlles J, Ros E, Piera C, Puig de la Bellacasa J, Cobos A, Lomena F, Rodriguez-Roisin R (1992) Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation: the effect of body position. Ann Intern Med 116:540-543
10. Zanella A, Cressoni M, Epp M, Stylianou M, Kolobow T (2008) A double-layer tracheal tube cuff designed to prevent leakage: a bench-top study. Intensive Care Med 34:1145-1149
11. Torres A, El-Ebiary M, Soler N, Monton C, Fabregas N, Hernandez C (1996) Stomach as a source of colonization of the respiratory tract during mechanical ventilation: association with ventilator-associated pneumonia. Eur Respir J 9:1729-1735
12. Bassi GL, Zanella A, Cressoni M, Stylianou M, Kolobow T (2008) Following tracheal intubation, mucus flow is reversed in the semirecumbent position: possible role in the pathogenesis of ventilator-associated pneumonia. Crit Care Med 36:518-525
13. Atkinson WJ (1970) Posture of the unconscious patient. Lancet 1:404-405
14. Alexiou VG, Ierodiakonou V, Dimopoulos G, Falagas ME (2009) Impact of patient position on the incidence of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials. J Crit Care 24:515-522
15. Cook DJ, Walter SD, Cook RJ, Griffith LE, Guyatt GH, Leasa D, Jaeschke RZ, Brun-Buisson C (1998) Incidence of and risk factors for ventilator- associated pneumonia in critically ill patients. Ann Intern Med 129:433-440
16. Orozco-Levi M, Torres A, Ferrer M, Piera C, El-Ebiary M, de la Bellacasa JP, Rodriguez-Roisin R (1995) Semirecumbent position protects from pulmonary aspiration but not completely from gastroesophageal reflux in mechanically ventilated patients. Am J Respir Crit Care Med 152:1387-1390
17. Vincent JL, Bihari DJ, Suter PM, Bruining HA, White J, Nicolas-Chanoin MH, Wolff M, Spencer RC, Hemmer M (1995) The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study EPIC International Advisory Committee. JAMA 274:639-644
18. Johanson WG Jr, Holcomb JR, Coalson JJ (1982) Experimental diffuse alveolar damage in baboons. Am Rev Respir Dis 126:142-151
19. Crouch TW, Higuchi JH, Coalson JJ, Johanson WG Jr (1984) Pathogenesis and prevention of nosocomial pneumonia in a nonhuman primate model of acute respiratory failure. Am Rev Respir Dis 130:502-504
20. Marquette CH, Wermert D, Wallet F, Copin MC, Tonnel AB (1999) Characterization of an animal model of ventilator-acquired pneumonia. Chest 115:200-209
21. Kuster SP, Ruef C, Ledergerber B, Hintermann A, Deplazes C, Neuber L, Weber R (2008) Quantitative antibiotic use in hospitals: comparison of measurements, literature review, and recommendations for a standard of reporting. Infection 36:549-559
22. Johanson WG Jr, Pierce AK, Sanford JP, Thomas GD (1972) Nosocomial respiratory infections with gramnegative bacilli. The significance of colonization of the respiratory tract. Ann Intern Med 77:701-706
23. Mauri T, Berra L, Kumwilaisak K, Pivi S, Ufberg JW, Kueppers F, Pesenti A, Bigatello LM (2010) Lateral-horizontal patient position and horizontal orientation of the endotracheal tube to prevent aspiration in adult surgical intensive care unit patients: a feasibility study. Respir Care 55:294-302
24. Aly H, Badawy M, El-Kholy A, Nabil R, Mohamed A (2008) Randomized, controlled trial on tracheal colonization of ventilated infants: can gravity prevent ventilator-associated pneumonia? Pediatrics 122:770-774
25. Hess DR (2005) Patient positioning and ventilator-associated pneumonia. Respir Care 50:892-898; discussion 898-899