Bacterial colonization of the respiratory tract following tracheal intubation - Effect of gravity: An experimental study

Critical Care Medicine

Volumn 31, Issue 3, 2003, Pages 729-737

  Panigada, Mario ^a   Berra, L ^a   Greco, G ^a   Stylianou, M ^a   Kolobow, T ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Body rotation; Lung bacterial colonization; Mechanical ventilation; Tracheal bacterial colonization; Tracheal tube orientation; Ventilator associated pneumonia

Indexed keywords

ANTIBIOTIC AGENT;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; AUTOPSY; BACTERIAL COLONIZATION; BACTERIUM CULTURE; BRONCHUS; CONTROLLED STUDY; ENDOTRACHEAL INTUBATION; ENDOTRACHEAL TUBE; FEMALE; GAS EXCHANGE; GRAVITY; LUNG FUNCTION; LUNG PARENCHYMA; NONHUMAN; NOSE FEEDING; PRIORITY JOURNAL; PROSPECTIVE STUDY; ROTATION; SHEEP; TRACHEA;

ANIMALS; BACTERIA; BACTERIAL TRANSLOCATION; BLOOD GAS ANALYSIS; BRONCHI; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; ENTERAL NUTRITION; FEMALE; GRAVITATION; HEAD; INTUBATION, INTRATRACHEAL; LUNG; NECK; PNEUMONIA, BACTERIAL; POSTURE; PROSPECTIVE STUDIES; PULMONARY GAS EXCHANGE; RANDOM ALLOCATION; RESPIRATION, ARTIFICIAL; RISK FACTORS; ROTATION; SHEEP; TIME FACTORS; TRACHEA;

EID: 0037352427     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000049943.01252.E5     Document Type: Article

References (28)

1. Vincent JL, Bihari DJ, Suter PM, et al: The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee. JAMA 1995; 274:639-644
2. Nair P, Jani K, Sanderson PJ: Transfer of oropharyngeal bacteria into the trachea during endotracheal intubation. J Hosp Infect 1986; 8:96-103
3. Craven DE, Kunches LM, Kilinsky V, et al: Risk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation. Am Rev Respir Dis 1986; 133:792-796
4. Johanson WG, Pierce AK, Sanford JP, et al: Nosocomial respiratory infections with Gram-negative bacilli. The significance of colonization of the respiratory tract. Ann Intern Med 1972; 77:701-706
5. Young PJ, Basson C, Hamilton D, et al: Prevention of tracheal aspiration using the pressure-limited tracheal tube cuff. Anaesthesia 1999; 54:559-563
6. Rello J, Sonora R, Jubert P, et al: Pneumonia in intubated patients: Role of respiratory airway care. Am J Respir Crit Care Med 1996; 154:111-115
7. van Uffelen R, van Saene HK, Fidler V, et al: Oropharyngeal flora as a source of bacteria colonizing the lower airways in patients on artificial ventilation. Intensive Care Med 1984; 10:233-237
8. Bergmans DC, Bonten MJ, Gaillard CA, et al: Prevention of ventilator-associated pneumonia by oral decontamination. A prospective, randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med 2001; 164:382-388
9. Atherton ST, White DJ: Stomach as source of bacteria colonising respiratory tract during artificial ventilation. Lancet 1978; 2:968-969
10. du Moulin GC, Paterson DG, Hedley-Whyte J, et al: Aspiration of gastric bacteria in antacid-treated patients: A frequent cause of post-operative colonisation of the airway. Lancet 1982; 1:242-245
11. Valles J, Artigas A, Rello J, et al: Continuous aspiration of subglottic secretions in preventing ventilator-associated pneumonia. Ann Intern Med 1995; 122:179-186
12. Drakulovic MB, Torres A, Bauer TT, et al: Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: A randomised trial. Lancet 1999; 354:1851-1858
13. Kollef MH: Ventilator-associated pneumonia. A multivariate analysis. JAMA 1993; 270:1965-1970
14. Torres A, Serra-Batlles J, Ros E, et al: Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation: The effect of body position. Ann Intern Med 1992; 116:540-543
15. Marquette CH, Wermert D, Wallet F, et al: Characterization of an animal model of ventilator-acquired pneumonia. Chest 1999; 115:200-209
16. Greco G, Panigada M, Kolobow T: Effect of tracheal tube position on tracheo-bronchial and lung bacterial colonization and nosocomial pneumonia. Abstr. Am J Respir Crit Care Med 2001; 163:A803
17. Ibanez J, Penafiel A, Raurich JM, et al: Gastroesophageal reflux in intubated patients receiving enteral nutrition: Effect of supine and semirecumbent positions. JPEN J Parenter Enteral Nutr 1992; 16:419-422
18. National Institutes of Health: Guide for the Care and Use of Laboratory Animals (NIH Publication No. 86-23). Washington, DC: U.S. Government Printing Office, 1985
19. Schalm OW, Jain NC, Carroll EJ: Veterinary Hematology. Philadelphia, 1975
20. Hecker JF: The Sheep as an Experimental Animal. New York, Harcourt Brace Jovanovic, 1983
21. Hollander MWDA: Nonparametric Statistical Methods. 1973
22. StatXact 3 for Windows: Statistical software for exact nonparametric inference [computer program]. Cytel Software Corporation, 1996
23. Sussman M: The Virulence of Escherichia coli. Reviews and Methods. New York, Academic Press, 1985
24. Gyles CL, Thoen CO: Pathogenesis of Bacterial Infections in Animals. Ames, IA, Iowa State University Press, 1993
25. Carter GR, Chengappa MM, Roberts AW: Essentials of Veterinary Microbiology. Baltimore, William & Wilkins, 1995
26. Starr PM, Stolp H, Truper HG, et al: The Prokaryotes. New York, Springer-Verlag, 1981
27. Inglis TJ, Sherratt MJ, Sproat LJ, et al: Gastroduodenal dysfunction and bacterial colonisation of the ventilated lung. Lancet 1993; 341:911-913
28. Hardy JP: Large volume gastroesophageal reflux: A rationale for risk reduction in the perioperative period. Can J Anaesth 1988; 35:162-173