Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients: A prospective study based on genomic DNA analysis

American Journal of Respiratory and Critical Care Medicine

Volumn 156, Issue 5, 1997, Pages 1647-1655

  Garrouste Orgeas, M ^a   Chevret, S ^a   Arlet, C ^a   Marie, O ^a   Rouveau, M ^a   Popoff, N ^a   Schlemmer, B ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA;

ACINETOBACTER; ADULT; AGED; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL PNEUMONIA; CONTROLLED STUDY; ENTEROBACTERIACEAE; FEMALE; GENOME; HOSPITAL INFECTION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MOUTH INFECTION; PHARYNGITIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STOMACH;

EID: 0030719853     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.156.5.96-04076     Document Type: Article

References (37)

1. Johanson, W. G., A. K. Pierce, S. P. Sanford, and G. D. Thomas. 1972. Nosocomial respiratory infections with gram negative bacilli: the significance of colonization of the respiratory tract. Ann. Intern. Med. 77: 701-704.
2. Craven, D. E., T. W. Barber, K. A. Steger, and M. A. Monecalvo. 1990. Nosocomial pneumonia in the 1990s: update of epidemiology and risk factors. Semin. Respir. Infect. 5:157-172.
3. Atherton, S. T., and D. J. White. 1978. Stomach as a source of bacteria colonizing respiratory tract during artificial ventilation. Lancet 2:968-969.
4. Du Moulin, G. C., D. G. Paterson, J. Hedley Whyte, and A. Lisbon. 1983. Aspiration of gastric bacteria in antacid treated patients: a frequent case of postoperative colonization of the airway. Lancet 1:242-245.
5. Cade, J. F., E. McOwat, R. Singaporia, C. Keighley, J. Preisnell, and V. Sinickas. 1992. Uncertain relevance of gastric colonization in the seriously ill. Intensive Care Med. 18:210-217.
6. Bonten, M. J. M., G. A. Gaillard, F. H. Van Tiel, G. G. W. Smeets, S. Van Der Geest, and E. E. Stobberingh. 1994. The stomach is not a source for colonization of the upper respiratory tract and pneumonia in ICU patients. Chest 105:878-884.
7. Tompkins, L. S. 1992. The use of molecular methods in infectious diseases. N. Engl. J. Med. 327:1290-1297.
8. Goering, R. V. 1993. Molecular epidemiology of nosocomial infection: analysis of chromosomal restriction patterns by pulsed-field gel electrophoresis. Infection Control and Hospital Epidemiology 14:595-600.
9. Gouby, A., M. J. Carles-Nury, N. Bouziges, G. Bourg, R. Mesnard, and P. Bouvet. 1992. Use of pulsed-field gel electrophoresis for investigation of hospital outbreaks of Acinetobacter baumannii. J. Clin. Microbiol. 30:1588-1591.
10. Ichiyama, S., M. Otha, K. Shimokata, N. Kato, and J. Takeuchi. 1991. Genomic DNA fingerprinting by pulse-field gel electrophoresis as an epidemiologic marker for study of nosocomial infections caused by methicillin-resistant Staphylococcus aureus. J. Clin. Microbiol. 29:2690-2695.
11. Schlichting, C., C. Branger, J. M. Fournier, W. Witte, A. Boutonnier, C. Wolz, P. Goullet, and G. Doring. 1993. Typing of Staphylococcus aureus by pulsed-field gel electrophoresis, zymotyping, capsular typing, and phage typing: resolution of clonal relationships. J. Clin. Microbiol. 3:227-232.
12. Bohm, H., and H. Karch. 1992. DNA fingerprinting of Escherichia coli O157 H7 strains by pulsed-field electrophoresis. J. Clin. Microbiol. 30:2169-2172.
13. Haertl, R., and G. Bandlow. 1993. Epidemiological fingerprinting of Enterobacter cloacae by small fragment restriction endonuclease analysis and pulsed-field gel electrophoresis of genomic restriction fragments. J. Clin. Microbiol. 31:128-133.
14. Poh, C. L., C. C. Yeo, and L. Tay. 1992. Genome fingerprinting by pulsed-field gel electrophoresis and ribotyping to differentiate Pseudomonas aeruginosa serotype 011 strains. Eur. J. Clin. Microbiol. Infecf. Dis. 11: 817-822.
15. Le Gall, J. R., P. Loirat, and A. Alperovitch. 1984. A simplified acute physiology score for ICU patients. Crit. Care Med. 12:957-977.
16. McCabe, W. R., and G. G. Jackson. 1962. Gram negative bacteremia: etiology and ecology. Arch. Intern. Med. 110:847-855.
17. Pham, L. A., C. Brun-Buisson, P. Legrand, A. Rauss, F. Verra, L. Brochard, and F. Lemaire. 1991. Diagnosis of nosocomial pneumonia in mechanically ventilated patients: comparison of a plugged telescoping catheter with the protected specimen brush. Am. Rev. Respir. Dis. 143: 1055-1061.
18. Chastre, J., F. Viau, P. Brun, J. Pierre, M. C. Dauge, A. Bouchama, A. Akesbi, and C. Gibert. 1984. Protective evaluation of the protected specimen brush for the diagnosis of pulmonary infections in ventilated patients. Am. Rev. Respir. Dis. 130:924-929.
19. Andrew, C. P., J. J. Coalson, J. D. Smith, and W. G. Johanson. 1981. Diagnosis of nosocomial bacterial pneumonia in acute lung injury. Chest 80:254-258.
20. Legrand, P., G. Fournier, A. Bure, V. Jarlier, M. H. Nicolas, D. Deere, J. Duval, and A. Philippon. 1989. Detection of extended spectrum betalactamase in Enterobacteriaceae in four French hospitals. Eur. J. Clin. Microbiol. Infect. Dis. 8:527-529.
21. Smith, C. L., and C. R. Cantor. 1987. Purification, specific fragmentation and separation of large DNA molecules. Methods Enzymol. 155:449-467.
22. Kaplan, E., and P. Meier. 1958. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53:457-481.
23. Peto, R., and J. Peto. 1972. Asymptotically efficient rank invariant test procedures. J. R. Stat. Soc. A. 135:185-206.
24. Cox, D. R. 1972. Regression models and life tables. J. R. Stat. Soc. B. 34: 187-220.
25. Johanson, W. G., A. K. Pierce, and J. P. Sanford. 1969. Changing pharyngeal flora of hospitalized patients. N. Engl. J. Med. 281:1137-1140.
26. Van Uffelen, R., H. K. F. Van Saene, V. Filder, and A. Lowenberg. 1984. Oropharyngeal flora as a source of bacteria colonizing the lower airways in patients on artificial ventilation. Intensive Care Med. 10:233-237.
27. Bonten, M. J. M., C. A. Gaillard, S. Van Der Geest, F. H. Van Tiel, A. J. Beysens, H. G. W. Smeets, and E. E. Stobberingh. 1995. The role of intragastric acidity and stress ulcus prophylaxis on colonization and infection in mechanically ventilated patients: a stratified, randomized, double-blind study of sucralfate versus antacids. Am. J. Respir. Crit. Care Med. 152:1825-1834.
28. Bonten, M. J. M., D. C. J. J. Bergmans, A. W. Ambergen, P. W. De Leeuw, S. Van Der Geest, E. E. Stobberingh, and C. A. Gaillard. 1996. Risk factors for pneumonia, and colonization of respiratory tract and stomach in mechanically ventilated ICU patients. Am. J. Respir. Crit. Care Med. 154:1339-1346.
29. Fagon, J. Y., J. Chastre, Y. Domart, J. L. Trouillet, J. Pierre, C. Darne, and C. Gibert. 1989. Nosocomial pneumonia in patients receiving continuous mechanical ventilation. Am. Rev. Respir. Dis. 139:877-884.
30. Fagon, J. Y., J. Chastre, A. J. Hance, P. Montravers, A. Novara, and C. Gibert. 1993. Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am. J. Med. 94:281-288.
31. Prevost, G., B. Jaulhac, and Y. Piemont. 1992. DNA fingerprinting by pulsed-field gel electrophoresis is more effective than ribotyping in distinguishing among methicillin-resistant Staphylococcus aureus isolates. J. Clin. Microbiol. 30:967-973.
32. De Latorre, F. J., T. Pont, A. Ferrer, J. Rossello, M. Palomar, and M. Planas. 1995. Pattern of tracheal colonization during mechanical ventilation. Am. J. Respir. Crit. Care Med. 152:1028-1033.
33. Niederman, M. S., R. Mantovani, P. Schoch, J. Papas, and A. M. Fein. 1989. Patterns and routes of tracheal bronchial colonization in mechanically ventilated patients: the role of nutritional status in colonization of the lower airway by Pseudomonas species. Chest 95:155-161.
34. Lortholary, O., J. Y. Fagon, A. Buu Hoi, M. A. Slama, J. Pierre, P. Giral, R. Rosenzweig, L. Gutmann, M. Safar, and J. Acar. 1995. Nosocomial acquisition of multiresistant Acinetobacter baumannii: risk factors and prognosis. Clin. Infect. Dis. 20:790-796.
35. Lucet, J. C., S. Chevret, D. Deere, D. Vanjak, A. Macrez, J. P. Bedos, M. Wolff, and B. Regnier. 1996. Outbreak of multiple resistant Enterobacteriaceae in an intensive care unit: epidemiology and risk factors for acquisition. Clin. Infect. Dis. 22:430-436.
36. Corbella, X., M. Pujol, J. Ayats, M. Sendra, C. Ardanuy, M. A. Dominguez, J. Linares, J. Ariza, and F. Gudiol. 1996. Relevance of digestive tract colonization in the epidemiology of nosocomial infections due to multiresistant Acinetobacter baumannii. Clin. Infect. Dis. 23:329-334.
37. Voss, A., D. Milatovic, C. Wallrauch-Schwarz, V. T. Rosdahl, and I. Braveny. 1994. Methicillin resistant Staphylococcus aureus in Europe. Eur. J. Clin. Microbiol. Infect. Dis. 13:50-55.