메뉴 건너뛰기




Volumn 64, Issue 7, 2012, Pages 595-602

BAFF/BLyS inhibitors: A new prospect for treatment of systemic lupus erythematosus

Author keywords

Atacicept; B cells; B1 B cells; BAFF; Belimumab; Benlysta; BLyS; IL 10; Lymphostat B; T cells

Indexed keywords

ANTIMALARIAL AGENT; ATACICEPT; B CELL ACTIVATING FACTOR; B CELL ACTIVATING FACTOR RECEPTOR; B CELL MATURATION ANTIGEN; BELIMUMAB; CORTICOSTEROID; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID; PLACEBO; TABALUMAB; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR;

EID: 84862536209     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1046     Document Type: Review
Times cited : (37)

References (63)
  • 1
    • 0033538468 scopus 로고    scopus 로고
    • BlyS: Member of the tumor necrosis factor family and B lymphocyte stimulator
    • Moore, P. A., Belvedere, O., Orr, A., Pieri, K., LaFleur, D. W., et al. (1999) BlyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 285, 260-263.
    • (1999) Science , vol.285 , pp. 260-263
    • Moore, P.A.1    Belvedere, O.2    Orr, A.3    Pieri, K.4    Lafleur, D.W.5
  • 2
    • 0033532634 scopus 로고    scopus 로고
    • BAFF, a novel ligand of the tumor necrosis factor (TNF) family, stimulates B-cell growth
    • Schneider, P., Mackay, F., Steiner, V., Hofmann, K., Bodmer, J. L., et al. (1999) BAFF, a novel ligand of the tumor necrosis factor (TNF) family, stimulates B-cell growth. J. Exp. Med. 189, 1747-1756.
    • (1999) J. Exp. Med. , vol.189 , pp. 1747-1756
    • Schneider, P.1    MacKay, F.2    Steiner, V.3    Hofmann, K.4    Bodmer, J.L.5
  • 4
    • 0032915632 scopus 로고    scopus 로고
    • TALL-1 is a novel member of the TNF family that is down-regulated by mitogens
    • Shu, H.-B., Hu, W.-H., and, Johnson, H., (1999) TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leuk. Biol. 65, 680-683.
    • (1999) J. Leuk. Biol. , vol.65 , pp. 680-683
    • Shu, H.-B.1    Hu, W.-H.2    Johnson, H.3
  • 5
    • 0033428703 scopus 로고    scopus 로고
    • Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
    • Mackay, F., Woodcock, S. A., Lawton, P., Ambrose, C., Baetscher, M., (1999) Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 190, 1697-1710.
    • (1999) J. Exp. Med. , vol.190 , pp. 1697-1710
    • MacKay, F.1    Woodcock, S.A.2    Lawton, P.3    Ambrose, C.4    Baetscher, M.5
  • 6
    • 0034601020 scopus 로고    scopus 로고
    • BAFF binds to the TNF receptor-like molecule BCMA and is important for maintaining the peripheral B cell population
    • Thompson, J. S., Schneider, P., Kalled, S. L., Wang, L., Lefevre, E. A., et al. (2000) BAFF binds to the TNF receptor-like molecule BCMA and is important for maintaining the peripheral B cell population. J. Exp. Med. 192, 129-135.
    • (2000) J. Exp. Med. , vol.192 , pp. 129-135
    • Thompson, J.S.1    Schneider, P.2    Kalled, S.L.3    Wang, L.4    Lefevre, E.A.5
  • 7
    • 0038076049 scopus 로고    scopus 로고
    • Ligand-receptor binding revealed by the TNF family member TALL-1
    • Liu, Y., Hong, X., Kappler, J., Jiang, L., Zhang, R., et al. (2003) Ligand-receptor binding revealed by the TNF family member TALL-1. Nature 423, 49-56.
    • (2003) Nature , vol.423 , pp. 49-56
    • Liu, Y.1    Hong, X.2    Kappler, J.3    Jiang, L.4    Zhang, R.5
  • 8
    • 0034694088 scopus 로고    scopus 로고
    • BAFF mediates survival of peripheral immature B lymphocytes
    • Batten, M., Groom, J., Cachero, T. G., Qian, F., Schneider, P., et al. (2000) BAFF mediates survival of peripheral immature B lymphocytes. J. Exp. Med. 192, 1453-1465.
    • (2000) J. Exp. Med. , vol.192 , pp. 1453-1465
    • Batten, M.1    Groom, J.2    Cachero, T.G.3    Qian, F.4    Schneider, P.5
  • 9
    • 0035860559 scopus 로고    scopus 로고
    • An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    • Schiemann, B., Gommerman, J. L., Vora, K., Cachero, T. G., Shulga-Morskaya, S., et al. (2001) An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293, 2111-2114.
    • (2001) Science , vol.293 , pp. 2111-2114
    • Schiemann, B.1    Gommerman, J.L.2    Vora, K.3    Cachero, T.G.4    Shulga-Morskaya, S.5
  • 10
    • 17944375043 scopus 로고    scopus 로고
    • TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease: Impaired B cell maturation in mice lacking BLyS
    • Gross, J. A., Dillon, S. R., Mudri, S., Johnston, J., Littau, A., et al. (2001) TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease: impaired B cell maturation in mice lacking BLyS. Immunity 15, 289-302.
    • (2001) Immunity , vol.15 , pp. 289-302
    • Gross, J.A.1    Dillon, S.R.2    Mudri, S.3    Johnston, J.4    Littau, A.5
  • 11
    • 13544261427 scopus 로고    scopus 로고
    • Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA
    • Day, E. S., Cachero, T. G., Qian, F., Sun, Y., Wen, D., et al. (2005) Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA. Biochemistry 44, 1919-1931.
    • (2005) Biochemistry , vol.44 , pp. 1919-1931
    • Day, E.S.1    Cachero, T.G.2    Qian, F.3    Sun, Y.4    Wen, D.5
  • 12
    • 77955882476 scopus 로고    scopus 로고
    • B-cell stage and context-dependent requirements for survival signals from BAFF and the B-cell receptor
    • Mackay, F., Figgett, W. A., Saulep, D., Lepage, M., and, Hibbs, M. L., (2010) B-cell stage and context-dependent requirements for survival signals from BAFF and the B-cell receptor. Immunol. Rev. 237, 205-225.
    • (2010) Immunol. Rev. , vol.237 , pp. 205-225
    • MacKay, F.1    Figgett, W.A.2    Saulep, D.3    Lepage, M.4    Hibbs, M.L.5
  • 13
    • 0242495115 scopus 로고    scopus 로고
    • Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B Lymphocyte Stimulator
    • Baker, K. P., Edwards, B. M., Main, S. H., Choi, G. H., Wager, R. E., et al. (2003) Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B Lymphocyte Stimulator. Arthritis Rheum 48, 3253-3265.
    • (2003) Arthritis Rheum , vol.48 , pp. 3253-3265
    • Baker, K.P.1    Edwards, B.M.2    Main, S.H.3    Choi, G.H.4    Wager, R.E.5
  • 14
    • 0035860466 scopus 로고    scopus 로고
    • BAFF-R, a novel TNF receptor that specifically interacts with BAFF
    • Thompson, J. S., Bixler, S. A., Qian, F., Vora, K., Scott, M. L., et al. (2001) BAFF-R, a novel TNF receptor that specifically interacts with BAFF. Science 293, 2108-2111.
    • (2001) Science , vol.293 , pp. 2108-2111
    • Thompson, J.S.1    Bixler, S.A.2    Qian, F.3    Vora, K.4    Scott, M.L.5
  • 15
    • 4043146475 scopus 로고    scopus 로고
    • B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation
    • Shulga-Morskaya, S., Dobles, M., Walsh, M. E., Ng, L. G., MacKay, F., et al. (2004) B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation. J. Immunol. 173, 2331-2341.
    • (2004) J. Immunol. , vol.173 , pp. 2331-2341
    • Shulga-Morskaya, S.1    Dobles, M.2    Walsh, M.E.3    Ng, L.G.4    MacKay, F.5
  • 16
    • 0035007222 scopus 로고    scopus 로고
    • B-cell maturation protein, which binds the Tumor Necrosis Factor family members BAFF and APRIL, is dispensable for humoral immune responses
    • Xu, S., and, Lam, K.-P., (2001) B-cell maturation protein, which binds the Tumor Necrosis Factor family members BAFF and APRIL, is dispensable for humoral immune responses. Mol. Cell. Biol. 21, 4067-4074.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4067-4074
    • Xu, S.1    Lam, K.-P.2
  • 17
    • 0347285357 scopus 로고    scopus 로고
    • BCMA is essential for the survival of long-lived bone marrow plasma cells
    • O'Connor, B. P., Raman, V. S., Erickson, L. D., Cook, W. J., Weaver, L. K., et al. (2004) BCMA is essential for the survival of long-lived bone marrow plasma cells. J. Exp. Med. 199, 91-97.
    • (2004) J. Exp. Med. , vol.199 , pp. 91-97
    • O'Connor, B.P.1    Raman, V.S.2    Erickson, L.D.3    Cook, W.J.4    Weaver, L.K.5
  • 18
    • 44849097480 scopus 로고    scopus 로고
    • Cutting edge: The dependence of plasma cells and independence of memory B cells on BAFF and APRIL
    • Benson, M. J., Dillon, S. R., Castigli, E., Geha, R. S., Xu, S., et al. (2008) Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J. Immunol. 180, 3655-3659.
    • (2008) J. Immunol. , vol.180 , pp. 3655-3659
    • Benson, M.J.1    Dillon, S.R.2    Castigli, E.3    Geha, R.S.4    Xu, S.5
  • 19
    • 0034919939 scopus 로고    scopus 로고
    • Activation and accumulation of B cells in TACI-deficient mice
    • Yan, M., Wang, H., Chan, B., Roose-Girma, M., Erickson, S., et al. (2001) Activation and accumulation of B cells in TACI-deficient mice. Nature Immunol. 2, 638-643.
    • (2001) Nature Immunol. , vol.2 , pp. 638-643
    • Yan, M.1    Wang, H.2    Chan, B.3    Roose-Girma, M.4    Erickson, S.5
  • 20
    • 0037332043 scopus 로고    scopus 로고
    • Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor
    • Seshasayee, D., Valdez, P., Yan, M., Dixit, V. M., Tumas, D., et al. (2003) Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity 18, 279-288.
    • (2003) Immunity , vol.18 , pp. 279-288
    • Seshasayee, D.1    Valdez, P.2    Yan, M.3    Dixit, V.M.4    Tumas, D.5
  • 21
    • 0035004320 scopus 로고    scopus 로고
    • Regulation of the T-independent humoral response by TACI
    • von Bulow, G.-U., van Deursen, J. M., and, Bram, R. J., (2001) Regulation of the T-independent humoral response by TACI. Immunity 14, 573-582.
    • (2001) Immunity , vol.14 , pp. 573-582
    • Von Bulow, G.-U.1    Van Deursen, J.M.2    Bram, R.J.3
  • 22
    • 67649172968 scopus 로고    scopus 로고
    • Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells
    • e1275.
    • Ozcan, E., Garibyan, L., Lee, J. J., Bram, R. J., Lam, K. P., et al. (2009) Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells. J. Allergy Clin. Immunol. 123, 1277-1286 e1275.
    • (2009) J. Allergy Clin. Immunol. , vol.123 , pp. 1277-1286
    • Ozcan, E.1    Garibyan, L.2    Lee, J.J.3    Bram, R.J.4    Lam, K.P.5
  • 23
    • 38949206321 scopus 로고    scopus 로고
    • TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts
    • Bossen, C., Cachero, T. G., Tardivel, A., Ingold, K., Willen, L., et al. (2008) TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. Blood 111, 1004-1012.
    • (2008) Blood , vol.111 , pp. 1004-1012
    • Bossen, C.1    Cachero, T.G.2    Tardivel, A.3    Ingold, K.4    Willen, L.5
  • 24
    • 0035803468 scopus 로고    scopus 로고
    • Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen
    • Schneider, P., Takatsuka, H., Wilson, A., Mackay, F., Tardivel, A., et al. (2001) Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. J. Exp. Med. 194, 1691-1697.
    • (2001) J. Exp. Med. , vol.194 , pp. 1691-1697
    • Schneider, P.1    Takatsuka, H.2    Wilson, A.3    MacKay, F.4    Tardivel, A.5
  • 25
    • 18644369740 scopus 로고    scopus 로고
    • BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-κB2
    • Kayagaki, N., Yan, M., Seshasayee, D., Wang, H., Lee, W., et al. (2002) BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-κB2. Immunity 10, 515-524.
    • (2002) Immunity , vol.10 , pp. 515-524
    • Kayagaki, N.1    Yan, M.2    Seshasayee, D.3    Wang, H.4    Lee, W.5
  • 27
    • 33748872264 scopus 로고    scopus 로고
    • Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cells
    • Fletcher, C. A., Sutherland, A. P., Groom, J. R., Batten, M. L., Ng, L. G., et al. (2006). Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cells. Eur. J. Immunol. 36, 2504-2014.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 2504-2014
    • Fletcher, C.A.1    Sutherland, A.P.2    Groom, J.R.3    Batten, M.L.4    Ng, L.G.5
  • 28
    • 10744224617 scopus 로고    scopus 로고
    • B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: Longitudinal observations
    • Stohl, W., Metyas, S., Tan, S. M., Cheema, G. S., Oamar, B., et al. (2003) B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations. Arthritis Rheum. 48, 3475-3486.
    • (2003) Arthritis Rheum. , vol.48 , pp. 3475-3486
    • Stohl, W.1    Metyas, S.2    Tan, S.M.3    Cheema, G.S.4    Oamar, B.5
  • 29
    • 0035167632 scopus 로고    scopus 로고
    • A role for B lymphocyte stimulator in systemic lupus erythematosus
    • Zhang, J., Roschke, V., Baker, K. P., Wang, Z., Alarcon, G. S., et al. (2001) A role for B lymphocyte stimulator in systemic lupus erythematosus. J. Immunol. 166, 6-10.
    • (2001) J. Immunol. , vol.166 , pp. 6-10
    • Zhang, J.1    Roschke, V.2    Baker, K.P.3    Wang, Z.4    Alarcon, G.S.5
  • 30
    • 79952070370 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: A randomised, placebo-controlled, phase 3 trial
    • Navarra, S. V., Guzman, R. M., Gallacher, A. E., Hall, S., Levy, R. A., et al. (2011) Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 377, 721-731.
    • (2011) Lancet , vol.377 , pp. 721-731
    • Navarra, S.V.1    Guzman, R.M.2    Gallacher, A.E.3    Hall, S.4    Levy, R.A.5
  • 31
  • 32
    • 78649958105 scopus 로고    scopus 로고
    • Belimumab, a BLys-specific inhibitor, reduces disease activity and severe flares in seropositive SLE patients: BLISS-76 study
    • Section 74
    • Vollenhoven, R., Zamani, O., Wallace, D,., Tagzova, D., M. J., et al. (2010) Belimumab, a BLys-specific inhibitor, reduces disease activity and severe flares in seropositive SLE patients: BLISS-76 study. Ann. Rheum. Dis. 69 (Suppl 3) p. 1 Section 74.
    • (2010) Ann. Rheum. Dis. , vol.69 , Issue.SUPPL. 3 , pp. 1
    • Vollenhoven, R.1    Zamani, O.2    Wallace, D.3    Tagzova, D.4
  • 33
    • 79953223940 scopus 로고    scopus 로고
    • Belimumab, a BLys-specific inhibitor, reduced disease activity, flares, and steroid use in patients with seropositive systemic lupus erythematosus (SLE): BLISS-52 study
    • Section 555. 1. Accessed on April 26, 2012.
    • Navarra, S., Ilianova, E., Bae, S., Guzman, R., Tanasescu, C., et al. (2010) Belimumab, a BLys-specific inhibitor, reduced disease activity, flares, and steroid use in patients with seropositive systemic lupus erythematosus (SLE): BLISS-52 study. Ann. Rheum. Dis. 69 (Suppl 3) p. 1 Section 555. Available at:, 1. Accessed on April 26, 2012.
    • (2010) Ann. Rheum. Dis. , vol.69 , Issue.SUPPL. 3 , pp. 1
    • Navarra, S.1    Ilianova, E.2    Bae, S.3    Guzman, R.4    Tanasescu, C.5
  • 34
    • 0033883546 scopus 로고    scopus 로고
    • Damage in systemic lupus erythematosus and its association with corticosteroids
    • Zonana-Nacach, A., Barr, S. G., Magder, L. S., and, Petri, M., (2000) Damage in systemic lupus erythematosus and its association with corticosteroids. Arthritis Rheum 43, 1801-1808.
    • (2000) Arthritis Rheum , vol.43 , pp. 1801-1808
    • Zonana-Nacach, A.1    Barr, S.G.2    Magder, L.S.3    Petri, M.4
  • 35
    • 0035043299 scopus 로고    scopus 로고
    • Treatment of lupus with corticosteroids
    • Chatham, W. W., and, Kimberly, R. P., (2001) Treatment of lupus with corticosteroids. Lupus 10, 140-147.
    • (2001) Lupus , vol.10 , pp. 140-147
    • Chatham, W.W.1    Kimberly, R.P.2
  • 36
    • 38849104447 scopus 로고    scopus 로고
    • Regulated expression of BAFF-binding receptors during human B cell differentiation
    • Darce, J. R., Arendt, B. K., Wu, X., and, Jelinek, D. F., (2007) Regulated expression of BAFF-binding receptors during human B cell differentiation. J. Immunol. 179, 7276-7286.
    • (2007) J. Immunol. , vol.179 , pp. 7276-7286
    • Darce, J.R.1    Arendt, B.K.2    Wu, X.3    Jelinek, D.F.4
  • 37
    • 84862002288 scopus 로고    scopus 로고
    • Belimumab reduces autoantibodies, normalizes low complement, and reduces select B-cell populations in patients with systemic lupus erythematosus
    • 2012 Jan 24. Epub ahead of print
    • Stohl, W., Hiepe, F., Latinis, K. M., Thomas, M., Scheinberg, M. A., et al. (2012) Belimumab reduces autoantibodies, normalizes low complement, and reduces select B-cell populations in patients with systemic lupus erythematosus. Arthritis Rheum, 2012 Jan 24. Epub ahead of print.
    • (2012) Arthritis Rheum
    • Stohl, W.1    Hiepe, F.2    Latinis, K.M.3    Thomas, M.4    Scheinberg, M.A.5
  • 38
    • 69749120918 scopus 로고    scopus 로고
    • A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus
    • Wallace, D. J., Stohl, W., Furie, R. A., Lisse, J. R., McKay, J. D., et al. (2009) A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus. Arthritis Rheum. 61, 1168-1178.
    • (2009) Arthritis Rheum. , vol.61 , pp. 1168-1178
    • Wallace, D.J.1    Stohl, W.2    Furie, R.A.3    Lisse, J.R.4    McKay, J.D.5
  • 39
    • 0037073930 scopus 로고    scopus 로고
    • Maintenance of serological memory by polyclonal activation of human memory B cells
    • Bernasconi, N. L., Traggiai, E., and, Lanzavecchia, A., (2002) Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298, 2199-2202.
    • (2002) Science , vol.298 , pp. 2199-2202
    • Bernasconi, N.L.1    Traggiai, E.2    Lanzavecchia, A.3
  • 41
    • 79953191650 scopus 로고    scopus 로고
    • Belimumab, a BLys-specific inhibitor, significantly reduced autoantibodies and normalized low complement in patients with seropositive systemic lupus erythematosus (SLE): BLISS-52 study
    • Available at:, 1
    • Levy, R. A., Ilianova, E., Ionescu, R., Yu, C. L., Kang, Y. M., et al. (2010) Belimumab, a BLys-specific inhibitor, significantly reduced autoantibodies and normalized low complement in patients with seropositive systemic lupus erythematosus (SLE): BLISS-52 study. Ann. Rheum. Dis. 69 (Suppl 3), 1. Available at:, 1.
    • (2010) Ann. Rheum. Dis. , vol.69 , Issue.SUPPL. 3 , pp. 1
    • Levy, R.A.1    Ilianova, E.2    Ionescu, R.3    Yu, C.L.4    Kang, Y.M.5
  • 43
    • 0017193927 scopus 로고
    • The metabolism of IgE. Studies in normal individuals and in a patient with IgE myeloma
    • Waldmann, T. A., Iio, A., Ogawa, M., McIntyre, O. R., and, Strober, W., (1976) The metabolism of IgE. Studies in normal individuals and in a patient with IgE myeloma. J. Immunol. 117, 1139-1144.
    • (1976) J. Immunol. , vol.117 , pp. 1139-1144
    • Waldmann, T.A.1    Iio, A.2    Ogawa, M.3    McIntyre, O.R.4    Strober, W.5
  • 44
    • 2942518502 scopus 로고    scopus 로고
    • Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches
    • Thien, M., Phan, T. G., Gardam, S., Amesbury, M., Basten, A., et al. (2004) Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity 20, 785-798.
    • (2004) Immunity , vol.20 , pp. 785-798
    • Thien, M.1    Phan, T.G.2    Gardam, S.3    Amesbury, M.4    Basten, A.5
  • 45
    • 84862580733 scopus 로고    scopus 로고
    • Changes in circulating B-cell subtype counts, autoantibody levels and immunoglobulins that associate with therapeutic responsiveness in SLE to BLys protein antagonism by belimumab
    • Chatham, W., Stohl, W., Merrill, J. T., Gruhn, W., Aranow, C., et al. (2007) Changes in circulating B-cell subtype counts, autoantibody levels and immunoglobulins that associate with therapeutic responsiveness in SLE to BLys protein antagonism by belimumab. Ann. Rheum. Dis. 66 (Suppl 11), 459. Available at:.
    • (2007) Ann. Rheum. Dis. , vol.66 , Issue.SUPPL. 11 , pp. 459
    • Chatham, W.1    Stohl, W.2    Merrill, J.T.3    Gruhn, W.4    Aranow, C.5
  • 46
    • 77955140720 scopus 로고    scopus 로고
    • Blockade of B-cell-activating factor suppresses lupus-like syndrome in autoimmune BXSB mice
    • Ding, H., Wang, L., Wu, X., Yan, J., He, Y., et al. (2010) Blockade of B-cell-activating factor suppresses lupus-like syndrome in autoimmune BXSB mice. J. Cell. Mol. Med. 14, 1717-1725.
    • (2010) J. Cell. Mol. Med. , vol.14 , pp. 1717-1725
    • Ding, H.1    Wang, L.2    Wu, X.3    Yan, J.4    He, Y.5
  • 47
    • 84862542043 scopus 로고    scopus 로고
    • American College of Rheumatology Hotline. Available at:. Accessed on May 16, 2012.
    • Hsieh, C., (2011) "Belimumab for systemic lupus erythematosus". American College of Rheumatology Hotline. Available at:. Accessed on May 16, 2012.
    • (2011) "belimumab for Systemic Lupus Erythematosus".
    • Hsieh, C.1
  • 48
    • 84860877614 scopus 로고    scopus 로고
    • Market snapshot: After Benlysta breakthrough, how high the sky in lupus?
    • Accessed on April 26, 2012.
    • Hayes, E., (2009) Market snapshot: after Benlysta breakthrough, how high the sky in lupus? BioPharmaToday. Available at:. Accessed on April 26, 2012.
    • (2009) BioPharmaToday
    • Hayes, E.1
  • 49
    • 17344380531 scopus 로고    scopus 로고
    • TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
    • Gross, J. A., Johnston, J., Mudri, S., Enselman, R., Dillon, S. R., et al. (2000) TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 404, 995-950.
    • (2000) Nature , vol.404 , pp. 995-950
    • Gross, J.A.1    Johnston, J.2    Mudri, S.3    Enselman, R.4    Dillon, S.R.5
  • 50
    • 38149114077 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis: Results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study
    • Tak, P. P., Thurlings, R. M., Rossier, C., Nestorov, I., Dimic, A., et al. (2008) Atacicept in patients with rheumatoid arthritis: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study. Arthritis Rheum. 58, 61-72.
    • (2008) Arthritis Rheum. , vol.58 , pp. 61-72
    • Tak, P.P.1    Thurlings, R.M.2    Rossier, C.3    Nestorov, I.4    Dimic, A.5
  • 52
    • 84862518069 scopus 로고    scopus 로고
    • Phase 2 study of safety and efficacy of a novel Anti-BAFF monoclonal antibody, in patients with RA treated with methotrexate (MTX)
    • Philadelphia
    • Genovese, M. C., M. E., Biagini, M., Bojin, S., and, J. Sloan-Lancaster,. (2009) Phase 2 study of safety and efficacy of a novel Anti-BAFF monoclonal antibody, in patients with RA treated with methotrexate (MTX). American College of Rheumatology National Meeting, 2009, Philadelphia.
    • (2009) American College of Rheumatology National Meeting, 2009
    • Genovese, M.C.1    Biagini, M.2    Bojin, S.3    Sloan-Lancaster, J.4
  • 53
    • 43049156086 scopus 로고    scopus 로고
    • A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
    • Yanaba, K., Bouaziz, J. D., Haas, K. M., Poe, J. C., Fujimoto, M., et al. (2008) A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 28, 639-650.
    • (2008) Immunity , vol.28 , pp. 639-650
    • Yanaba, K.1    Bouaziz, J.D.2    Haas, K.M.3    Poe, J.C.4    Fujimoto, M.5
  • 55
    • 77957145333 scopus 로고    scopus 로고
    • What are regulatory B cells?
    • Gray, D, and, Gray, M., (2010) What are regulatory B cells? Eur. J. Immunol. 40, 2677-2679.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 2677-2679
    • Gray, D.1    Gray, M.2
  • 56
    • 34548223736 scopus 로고    scopus 로고
    • Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus
    • Chun, H. Y., Chung, J. W., Kim, H. A., Yun, J. M., Jeon, J. Y., et al. (2007) Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J. Clin. Immunol. 27, 461-466.
    • (2007) J. Clin. Immunol. , vol.27 , pp. 461-466
    • Chun, H.Y.1    Chung, J.W.2    Kim, H.A.3    Yun, J.M.4    Jeon, J.Y.5
  • 58
    • 3142671331 scopus 로고    scopus 로고
    • B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells
    • Ng, L. G., Sutherland, A. P., Newton, R., Qian, F., Cachero, T. G., et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J. Immunol. 173, 807-817.
    • (2004) J. Immunol. , vol.173 , pp. 807-817
    • Ng, L.G.1    Sutherland, A.P.2    Newton, R.3    Qian, F.4    Cachero, T.G.5
  • 59
    • 77949322552 scopus 로고    scopus 로고
    • Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6
    • Tsantikos, E., Oracki, S. A., Quilici, C., Anderson, G. P., Tarlinton, D. M., et al. (2010) Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6. J. Immunol. 184, 1348-1360.
    • (2010) J. Immunol. , vol.184 , pp. 1348-1360
    • Tsantikos, E.1    Oracki, S.A.2    Quilici, C.3    Anderson, G.P.4    Tarlinton, D.M.5
  • 60
    • 34547772125 scopus 로고    scopus 로고
    • BAFF and MyD88 signals promote a lupuslike disease independent of T cells
    • Groom, J. R., Fletcher, C. A., Walters, S. N., Grey, S. T., Watt, S. V., et al. (2007) BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J. Exp. Med. 204, 1959-1971.
    • (2007) J. Exp. Med. , vol.204 , pp. 1959-1971
    • Groom, J.R.1    Fletcher, C.A.2    Walters, S.N.3    Grey, S.T.4    Watt, S.V.5
  • 61
    • 75649103234 scopus 로고    scopus 로고
    • How can we reduce the risk of serious infection for patients with systemic lupus erythematosus?
    • Kamen, D. L., (2009) How can we reduce the risk of serious infection for patients with systemic lupus erythematosus? Arthritis Res. Ther. 11, 129.
    • (2009) Arthritis Res. Ther. , vol.11 , pp. 129
    • Kamen, D.L.1
  • 62
    • 33845267004 scopus 로고    scopus 로고
    • Lupus nephritis: Toll the trigger!
    • Smith, K. D., (2006) Lupus nephritis: toll the trigger! J. Am. Soc. Nephrol. 17, 3273-3275.
    • (2006) J. Am. Soc. Nephrol. , vol.17 , pp. 3273-3275
    • Smith, K.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.