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Volumn 4, Issue , 2012, Pages 53-64

New developments in the treatment of HER2-positive breast cancer

Author keywords

Affitoxin; Drug resistance; ErbB2; Herceptin; Lapatinib; Neratinib; Trastuzumab

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; AFFITOXIN; CAPECITABINE; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; FLAVOPIRIDOL; GEFITINIB; IMMUNOTOXIN; LAPATINIB; NERATINIB; OBATOCLAX; PACLITAXEL; PERTUZUMAB; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; UNCLASSIFIED DRUG;

EID: 84862517915     PISSN: None     EISSN: 11791314     Source Type: Journal    
DOI: 10.2147/bctt.s24976     Document Type: Article
Times cited : (17)

References (115)
  • 2
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sørlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature. 2000;406(6797):747-752.
    • (2000) Nature , vol.406 , Issue.6797 , pp. 747-752
    • Perou, C.M.1    Sørlie, T.2    Eisen, M.B.3
  • 3
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sørlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A. 2001;98(19):10869-10874.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.19 , pp. 10869-10874
    • Sørlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 5
    • 0030944455 scopus 로고    scopus 로고
    • ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
    • Graus-Porta D, Beerli RR, Daly JM, Hynes NE. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 1997;16(7):1647-1655.
    • (1997) EMBO J , vol.16 , Issue.7 , pp. 1647-1655
    • Graus-Porta, D.1    Beerli, R.R.2    Daly, J.M.3    Hynes, N.E.4
  • 6
    • 79952233837 scopus 로고    scopus 로고
    • Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers
    • Ghosh R, Narasanna A, Wang SE, et al. Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers. Cancer Res. 2011;71(5):1871-1882.
    • (2011) Cancer Res , vol.71 , Issue.5 , pp. 1871-1882
    • Ghosh, R.1    Narasanna, A.2    Wang, S.E.3
  • 7
    • 0042307325 scopus 로고    scopus 로고
    • The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
    • Holbro T, Beerli RR, Maurer F, Koziczak M, Barbas CF 3rd, Hynes NE. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci U S A. 2003;100(15):8933-8938.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.15 , pp. 8933-8938
    • Holbro, T.1    Beerli, R.R.2    Maurer, F.3    Koziczak, M.4    Barbas III, C.F.5    Hynes, N.E.6
  • 8
    • 0028077047 scopus 로고
    • Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the ErbB3 gene product
    • Kim HH, Sierke SL, Koland JG. Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the ErbB3 gene product. J Biol Chem. 1994;269(40):24747-24755.
    • (1994) J Biol Chem , vol.269 , Issue.40 , pp. 24747-24755
    • Kim, H.H.1    Sierke, S.L.2    Koland, J.G.3
  • 9
    • 0028302018 scopus 로고
    • ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor
    • Soltoff SP, Carraway KL 3rd, Prigent SA, Gullick WG, Cantley LC. ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol Cell Biol. 1994;14(6):3550-3558.
    • (1994) Mol Cell Biol , vol.14 , Issue.6 , pp. 3550-3558
    • Soltoff, S.P.1    Carraway III, K.L.2    Prigent, S.A.3    Gullick, W.G.4    Cantley, L.C.5
  • 10
    • 0035496541 scopus 로고    scopus 로고
    • The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis
    • Eccles SA. The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis. J Mammary Gland Biol Neoplasia. 2001;6(4):393-406.
    • (2001) J Mammary Gland Biol Neoplasia , vol.6 , Issue.4 , pp. 393-406
    • Eccles, S.A.1
  • 11
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235(4785):177-182.
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 12
    • 69949109923 scopus 로고    scopus 로고
    • mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary
    • Mabuchi S, Kawase C, Altomare DA, et al. mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary. Clin Cancer Res. 2009;15(17): 5404-5413.
    • (2009) Clin Cancer Res , vol.15 , Issue.17 , pp. 5404-5413
    • Mabuchi, S.1    Kawase, C.2    Altomare, D.A.3
  • 13
    • 0024478054 scopus 로고
    • P185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor
    • Hudziak RM, Lewis GD, Winget M, Fendly BM, Shepard HM, Ullrich A. p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. Mol Cell Biol. 1989;9(3):1165-1172.
    • (1989) Mol Cell Biol , vol.9 , Issue.3 , pp. 1165-1172
    • Hudziak, R.M.1    Lewis, G.D.2    Winget, M.3    Fendly, B.M.4    Shepard, H.M.5    Ullrich, A.6
  • 14
    • 0025968042 scopus 로고
    • Regulation of phosphorylation of the c-erbB-2/HER2 gene product by a monoclonal antibody and serum growth factor(s) in human mammary carcinoma cells
    • Kumar R, Shepard HM, Mendelsohn J. Regulation of phosphorylation of the c-erbB-2/HER2 gene product by a monoclonal antibody and serum growth factor(s) in human mammary carcinoma cells. Mol Cell Biol. 1991;11(2):979-986.
    • (1991) Mol Cell Biol , vol.11 , Issue.2 , pp. 979-986
    • Kumar, R.1    Shepard, H.M.2    Mendelsohn, J.3
  • 15
    • 0028200221 scopus 로고
    • Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells
    • Pietras RJ, Fendly BM, Chazin VR, Pegram MD, Howell SB, Slamon DJ. Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells. Oncogene. 1994;9(7):1829-1838.
    • (1994) Oncogene , vol.9 , Issue.7 , pp. 1829-1838
    • Pietras, R.J.1    Fendly, B.M.2    Chazin, V.R.3    Pegram, M.D.4    Howell, S.B.5    Slamon, D.J.6
  • 16
    • 0032578797 scopus 로고    scopus 로고
    • Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs
    • Pietras RJ, Pegram MD, Finn RS, Maneval DA, Slamon DJ. Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs. Oncogene. 1998;17(17):2235-2249.
    • (1998) Oncogene , vol.17 , Issue.17 , pp. 2235-2249
    • Pietras, R.J.1    Pegram, M.D.2    Finn, R.S.3    Maneval, D.A.4    Slamon, D.J.5
  • 17
    • 0026610881 scopus 로고
    • Humanization of an antip185HER2 antibody for human cancer therapy
    • Carter P, Presta L, Gorman CM, et al. Humanization of an antip185HER2 antibody for human cancer therapy. Proc Natl Acad Sci U S A. 1992;89(10):4285-4289.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.10 , pp. 4285-4289
    • Carter, P.1    Presta, L.2    Gorman, C.M.3
  • 18
    • 0032127350 scopus 로고    scopus 로고
    • Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
    • Baselga J, Norton L, Albanell J, Kim YM, Mendelsohn J. Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res. 1998; 58(13):2825-2831.
    • (1998) Cancer Res , vol.58 , Issue.13 , pp. 2825-2831
    • Baselga, J.1    Norton, L.2    Albanell, J.3    Kim, Y.M.4    Mendelsohn, J.5
  • 19
    • 0032825577 scopus 로고    scopus 로고
    • Combination therapy with trastuzumab (Herceptin) and cisplatin for chemoresistant metastatic breast cancer: Evidence for receptor-enhanced chemosensitivity
    • Pegram MD, Slamon DJ. Combination therapy with trastuzumab (Herceptin) and cisplatin for chemoresistant metastatic breast cancer: evidence for receptor-enhanced chemosensitivity. Semin Oncol. 1999; 26(4 Suppl 12):89-95.
    • (1999) Semin Oncol , vol.26 , Issue.4 SUPPL 12 , pp. 89-95
    • Pegram, M.D.1    Slamon, D.J.2
  • 21
    • 84858189073 scopus 로고    scopus 로고
    • Pharmacological strategies to overcome HER2 crosstalk and trastuzumab resistance
    • Nahta R. Pharmacological strategies to overcome HER2 crosstalk and trastuzumab resistance. Curr Med Chem. 2012;19(7): 1065-1075.
    • (2012) Curr Med Chem , vol.19 , Issue.7 , pp. 1065-1075
    • Nahta, R.1
  • 22
    • 33751344602 scopus 로고    scopus 로고
    • HER2 therapy: Molecular mechanisms of trastuzumab resistance
    • Nahta R, Esteva FJ. HER2 therapy: molecular mechanisms of trastuzumab resistance. Breast Cancer Res. 2006;8(6):215.
    • (2006) Breast Cancer Res , vol.8 , Issue.6 , pp. 215
    • Nahta, R.1    Esteva, F.J.2
  • 23
    • 31644439702 scopus 로고    scopus 로고
    • Herceptin: Mechanisms of action and resistance
    • Nahta R, Esteva FJ. Herceptin: mechanisms of action and resistance. Cancer Lett. 2006;232(2):123-138.
    • (2006) Cancer Lett , vol.232 , Issue.2 , pp. 123-138
    • Nahta, R.1    Esteva, F.J.2
  • 24
    • 34249672864 scopus 로고    scopus 로고
    • Trastuzumab: Triumphs and tribulations
    • Nahta R, Esteva FJ. Trastuzumab: triumphs and tribulations. Oncogene. 2007;26(25):3637-3643.
    • (2007) Oncogene , vol.26 , Issue.25 , pp. 3637-3643
    • Nahta, R.1    Esteva, F.J.2
  • 25
    • 73649111355 scopus 로고    scopus 로고
    • Personalizing HER2-targeted therapy in metastatic breast cancer beyond HER2 status: What we have learned from clinical specimens
    • Nahta R, Shabaya S, Ozbay T, Rowe DL. Personalizing HER2-targeted therapy in metastatic breast cancer beyond HER2 status: what we have learned from clinical specimens. Curr Pharmacogenomics Person Med. 2009;7(4):263-274.
    • (2009) Curr Pharmacogenomics Person Med , vol.7 , Issue.4 , pp. 263-274
    • Nahta, R.1    Shabaya, S.2    Ozbay, T.3    Rowe, D.L.4
  • 26
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol. 2006;3(5):269-280.
    • (2006) Nat Clin Pract Oncol , vol.3 , Issue.5 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.C.3    Hortobagyi, G.N.4    Esteva, F.J.5
  • 27
    • 0035874898 scopus 로고    scopus 로고
    • Down-regulation of the ErbB-2 receptor by trastuzumab (Herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress ErbB-2
    • Cuello M, Ettenberg SA, Clark AS, et al. Down-regulation of the ErbB-2 receptor by trastuzumab (Herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress ErbB-2. Cancer Res. 2001;61(12):4892-4900.
    • (2001) Cancer Res , vol.61 , Issue.12 , pp. 4892-4900
    • Cuello, M.1    Ettenberg, S.A.2    Clark, A.S.3
  • 28
    • 79952162826 scopus 로고    scopus 로고
    • HER2-amplified breast cancer: Mechanisms of trastuzumab resistance and novel targeted therapies
    • Gajria D, Chandarlapaty S. HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies. Expert Rev Anticancer Ther. 2011;11(2):263-275.
    • (2011) Expert Rev Anticancer Ther , vol.11 , Issue.2 , pp. 263-275
    • Gajria, D.1    Chandarlapaty, S.2
  • 29
    • 65349101151 scopus 로고    scopus 로고
    • Ligand-independent HER2/ HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
    • Junttila TT, Akita RW, Parsons K, et al. Ligand-independent HER2/ HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell. 2009;15(5): 429-440.
    • (2009) Cancer Cell , vol.15 , Issue.5 , pp. 429-440
    • Junttila, T.T.1    Akita, R.W.2    Parsons, K.3
  • 30
    • 0035874981 scopus 로고    scopus 로고
    • Trastuzumab (Herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells
    • Molina MA, Codony-Servat J, Albanell J, Rojo F, Arribas J, Baselga J. Trastuzumab (Herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Res. 2001;61(12):4744-4749.
    • (2001) Cancer Res , vol.61 , Issue.12 , pp. 4744-4749
    • Molina, M.A.1    Codony-Servat, J.2    Albanell, J.3    Rojo, F.4    Arribas, J.5    Baselga, J.6
  • 31
    • 0034873273 scopus 로고    scopus 로고
    • Modulation of p27/ CDK2 complex formation through 4D5-mediated inhibition of HER2 receptor signaling
    • Lane HA, Motoyama AB, Beuvink I, Hynes NE. Modulation of p27/ CDK2 complex formation through 4D5-mediated inhibition of HER2 receptor signaling. Ann Oncol. 2001;12 Suppl 1:S21-S22.
    • (2001) Ann Oncol , vol.12 , Issue.SUPPL. 1
    • Lane, H.A.1    Motoyama, A.B.2    Beuvink, I.3    Hynes, N.E.4
  • 32
    • 0038607569 scopus 로고    scopus 로고
    • The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition
    • Le XF, Claret FX, Lammayot A, et al. The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition. J Biol Chem. 2003;278(26): 23441-23450.
    • (2003) J Biol Chem , vol.278 , Issue.26 , pp. 23441-23450
    • Le, X.F.1    Claret, F.X.2    Lammayot, A.3
  • 33
    • 0037149539 scopus 로고    scopus 로고
    • Tumour biology: Herceptin acts as an anti-angiogenic cocktail
    • Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK. Tumour biology: Herceptin acts as an anti-angiogenic cocktail. Nature. 2002;416(6878):279-280.
    • (2002) Nature , vol.416 , Issue.6878 , pp. 279-280
    • Izumi, Y.1    Xu, L.2    di Tomaso, E.3    Fukumura, D.4    Jain, R.K.5
  • 34
    • 31444451572 scopus 로고    scopus 로고
    • Trastuzumab-based treatment of HER2-positive breast cancer: An antibody-dependent cellular cytotoxicity mechanism?
    • Arnould L, Gelly M, Penault-Llorca F, et al. Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism? Br J Cancer. 2006;94(2):259-267.
    • (2006) Br J Cancer , vol.94 , Issue.2 , pp. 259-267
    • Arnould, L.1    Gelly, M.2    Penault-Llorca, F.3
  • 35
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med. 2000;6(4):443-446.
    • (2000) Nat Med , vol.6 , Issue.4 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 36
    • 0029991439 scopus 로고    scopus 로고
    • Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer
    • Baselga J, Tripathy D, Mendelsohn J, et al. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol. 1996;14(3):737-744.
    • (1996) J Clin Oncol , vol.14 , Issue.3 , pp. 737-744
    • Baselga, J.1    Tripathy, D.2    Mendelsohn, J.3
  • 37
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
    • Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol. 1999;17(9):2639-2648.
    • (1999) J Clin Oncol , vol.17 , Issue.9 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3
  • 38
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol. 2002;20(3):719-726.
    • (2002) J Clin Oncol , vol.20 , Issue.3 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 39
    • 0036534121 scopus 로고    scopus 로고
    • Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
    • Esteva FJ, Valero V, Booser D, et al. Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer. J Clin Oncol. 2002;20(7):1800-1808.
    • (2002) J Clin Oncol , vol.20 , Issue.7 , pp. 1800-1808
    • Esteva, F.J.1    Valero, V.2    Booser, D.3
  • 40
    • 0035873815 scopus 로고    scopus 로고
    • Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification
    • Seidman AD, Fornier MN, Esteva FJ, et al. Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification. J Clin Oncol. 2001;19(10):2587-2595.
    • (2001) J Clin Oncol , vol.19 , Issue.10 , pp. 2587-2595
    • Seidman, A.D.1    Fornier, M.N.2    Esteva, F.J.3
  • 41
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344(11):783-792.
    • (2001) N Engl J Med , vol.344 , Issue.11 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 42
    • 0035553174 scopus 로고    scopus 로고
    • The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumorderived cell lines in vitro and in vivo
    • Rusnak DW, Lackey K, Affleck K, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumorderived cell lines in vitro and in vivo. Mol Cancer Ther. 2001;1(2): 85-94.
    • (2001) Mol Cancer Ther , vol.1 , Issue.2 , pp. 85-94
    • Rusnak, D.W.1    Lackey, K.2    Affleck, K.3
  • 43
    • 0037068741 scopus 로고    scopus 로고
    • Anti-tumor activity of GW572016: A dual tyrosine kinase inhibitor blocks EGF activation of EGFR/ ErbB2 and downstream ERK1/2 and AKT pathways
    • Xia W, Mullin RJ, Keith BR, et al. Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/ ErbB2 and downstream ERK1/2 and AKT pathways. Oncogene. 2002;21(41):6255-6263.
    • (2002) Oncogene , vol.21 , Issue.41 , pp. 6255-6263
    • Xia, W.1    Mullin, R.J.2    Keith, B.R.3
  • 44
    • 0942268145 scopus 로고    scopus 로고
    • Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2- overexpressing breast cancer cell line proliferation, radiosensitization, and resistance
    • Zhou H, Kim YS, Peletier A, McCall W, Earp HS, Sartor CI. Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2- overexpressing breast cancer cell line proliferation, radiosensitization, and resistance. Int J Radiat Oncol Biol Phys. 2004;58(2):344-352.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , Issue.2 , pp. 344-352
    • Zhou, H.1    Kim, Y.S.2    Peletier, A.3    McCall, W.4    Earp, H.S.5    Sartor, C.I.6
  • 45
    • 11244257032 scopus 로고    scopus 로고
    • The dual ErbB1/ ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer
    • Chu I, Blackwell K, Chen S, Slingerland J. The dual ErbB1/ ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005;65(1): 18-25.
    • (2005) Cancer Res , vol.65 , Issue.1 , pp. 18-25
    • Chu, I.1    Blackwell, K.2    Chen, S.3    Slingerland, J.4
  • 46
    • 51049091694 scopus 로고    scopus 로고
    • Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells
    • Zhang D, Pal A, Bornmann WG, et al. Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells. Mol Cancer Ther. 2008;7(7):1846-1850.
    • (2008) Mol Cancer Ther , vol.7 , Issue.7 , pp. 1846-1850
    • Zhang, D.1    Pal, A.2    Bornmann, W.G.3
  • 47
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med. 2006;355(26):2733-2743.
    • (2006) N Engl J Med , vol.355 , Issue.26 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 48
    • 77949884661 scopus 로고    scopus 로고
    • Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
    • Blackwell KL, Burstein HJ, Storniolo AM, et al. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol. 2010;28(7):1124-1130.
    • (2010) J Clin Oncol , vol.28 , Issue.7 , pp. 1124-1130
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3
  • 49
    • 70449517339 scopus 로고    scopus 로고
    • Lapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: Efficacy, safety, and biomarker results from Japanese patients phase II studies
    • Toi M, Iwata H, Fujiwara Y, et al. Lapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: efficacy, safety, and biomarker results from Japanese patients phase II studies. Br J Cancer. 2009;101(10):1676-1682.
    • (2009) Br J Cancer , vol.101 , Issue.10 , pp. 1676-1682
    • Toi, M.1    Iwata, H.2    Fujiwara, Y.3
  • 50
    • 42949112556 scopus 로고    scopus 로고
    • Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer
    • Lin NU, Carey LA, Liu MC, et al. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol. 2008;26(12):1993-1999.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 1993-1999
    • Lin, N.U.1    Carey, L.A.2    Liu, M.C.3
  • 51
    • 63149110733 scopus 로고    scopus 로고
    • Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer
    • Lin NU, Diéras V, Paul D, et al. Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin Cancer Res. 2009;15(4):1452-1459.
    • (2009) Clin Cancer Res , vol.15 , Issue.4 , pp. 1452-1459
    • Lin, N.U.1    Diéras, V.2    Paul, D.3
  • 52
    • 33745057881 scopus 로고    scopus 로고
    • HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer
    • Cappuzzo F, Bemis L, Varella-Garcia M. HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer. N Engl J Med. 2006;354(24):2619-2621.
    • (2006) N Engl J Med , vol.354 , Issue.24 , pp. 2619-2621
    • Cappuzzo, F.1    Bemis, L.2    Varella-Garcia, M.3
  • 53
    • 33745727112 scopus 로고    scopus 로고
    • HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
    • Wang SE, Narasanna A, Perez-Torres M, et al. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell. 2006;10(1):25-38.
    • (2006) Cancer Cell , vol.10 , Issue.1 , pp. 25-38
    • Wang, S.E.1    Narasanna, A.2    Perez-Torres, M.3
  • 54
    • 2542526069 scopus 로고    scopus 로고
    • P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells
    • Nahta R, Takahashi T, Ueno NT, Hung MC, Esteva FJ. P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells. Cancer Res. 2004;64(11):3981-3986.
    • (2004) Cancer Res , vol.64 , Issue.11 , pp. 3981-3986
    • Nahta, R.1    Takahashi, T.2    Ueno, N.T.3    Hung, M.C.4    Esteva, F.J.5
  • 55
    • 73149122573 scopus 로고    scopus 로고
    • Loss of HER2 amplification following trastuzumab-based neoadjuvant systemic therapy and survival outcomes
    • Mittendorf EA, Wu Y, Scaltriti M, et al. Loss of HER2 amplification following trastuzumab-based neoadjuvant systemic therapy and survival outcomes. Clin Cancer Res. 2009;15(23):7381-7388.
    • (2009) Clin Cancer Res , vol.15 , Issue.23 , pp. 7381-7388
    • Mittendorf, E.A.1    Wu, Y.2    Scaltriti, M.3
  • 56
    • 84863116159 scopus 로고    scopus 로고
    • Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors
    • Niikura N, Liu J, Hayashi N, et al. Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors. J Clin Oncol. 2012;30(6):593-599.
    • (2012) J Clin Oncol , vol.30 , Issue.6 , pp. 593-599
    • Niikura, N.1    Liu, J.2    Hayashi, N.3
  • 57
    • 0037142184 scopus 로고    scopus 로고
    • Rat MUC4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for Herceptin resistance
    • Price-Schiavi SA, Jepson S, Li P, et al. Rat MUC4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for Herceptin resistance. Int J Cancer. 2002;99(6):783-791.
    • (2002) Int J Cancer , vol.99 , Issue.6 , pp. 783-791
    • Price-Schiavi, S.A.1    Jepson, S.2    Li, P.3
  • 58
    • 12544250996 scopus 로고    scopus 로고
    • Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a Herceptin-resistant, MUC4- expressing breast cancer cell line
    • Nagy P, Friedländer E, Tanner M, et al. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a Herceptin-resistant, MUC4- expressing breast cancer cell line. Cancer Res. 2005;65(2):473-482.
    • (2005) Cancer Res , vol.65 , Issue.2 , pp. 473-482
    • Nagy, P.1    Friedländer, E.2    Tanner, M.3
  • 59
    • 76249112330 scopus 로고    scopus 로고
    • Heterotrimerization of the growth factor receptors ErbB2, ErbB3, and insulin-like growth factor-I receptor in breast cancer cells resistant to Herceptin
    • Huang X, Gao L, Wang S, et al. Heterotrimerization of the growth factor receptors ErbB2, ErbB3, and insulin-like growth factor-I receptor in breast cancer cells resistant to Herceptin. Cancer Res. 2010;70(3):1204-1214.
    • (2010) Cancer Res , vol.70 , Issue.3 , pp. 1204-1214
    • Huang, X.1    Gao, L.2    Wang, S.3
  • 60
    • 28244432561 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
    • Nahta R, Yuan LX, Zhang B, Kobayashi R, Esteva FJ. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res. 2005;65(23):11118-11128.
    • (2005) Cancer Res , vol.65 , Issue.23 , pp. 11118-11128
    • Nahta, R.1    Yuan, L.X.2    Zhang, B.3    Kobayashi, R.4    Esteva, F.J.5
  • 61
    • 51049095723 scopus 로고    scopus 로고
    • Nordihydroguaiaretic acid, a cytotoxic insulin-like growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer
    • Rowe DL, Ozbay T, Bender LM, Nahta R. Nordihydroguaiaretic acid, a cytotoxic insulin-like growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer. Mol Cancer Ther. 2008;7(7):1900-1908.
    • (2008) Mol Cancer Ther , vol.7 , Issue.7 , pp. 1900-1908
    • Rowe, D.L.1    Ozbay, T.2    Bender, L.M.3    Nahta, R.4
  • 62
    • 34548071359 scopus 로고    scopus 로고
    • Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network
    • Ritter CA, Perez-Torres M, Rinehart C, et al. Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network. Clin Cancer Res. 2007;13(16):4909-4919.
    • (2007) Clin Cancer Res , vol.13 , Issue.16 , pp. 4909-4919
    • Ritter, C.A.1    Perez-Torres, M.2    Rinehart, C.3
  • 63
    • 40449113978 scopus 로고    scopus 로고
    • Met receptor contributes to trastuzumab resistance of HER2-overexpressing breast cancer cells
    • Shattuck DL, Miller JK, Carraway KL 3rd, Sweeney C. Met receptor contributes to trastuzumab resistance of HER2-overexpressing breast cancer cells. Cancer Res. 2008;68(5):1471-1477.
    • (2008) Cancer Res , vol.68 , Issue.5 , pp. 1471-1477
    • Shattuck, D.L.1    Miller, J.K.2    Carraway III., K.L.3    Sweeney, C.4
  • 64
    • 80053998053 scopus 로고    scopus 로고
    • Growth differentiation factor 15 (GDF15)-mediated HER2 phosphorylation reduces trastuzumab sensitivity of HER2-overexpressing breast cancer cells
    • Joshi JP, Brown NE, Griner SE, Nahta R. Growth differentiation factor 15 (GDF15)-mediated HER2 phosphorylation reduces trastuzumab sensitivity of HER2-overexpressing breast cancer cells. Biochem Pharmacol. 2011;82(9):1090-1099.
    • (2011) Biochem Pharmacol , vol.82 , Issue.9 , pp. 1090-1099
    • Joshi, J.P.1    Brown, N.E.2    Griner, S.E.3    Nahta, R.4
  • 65
    • 41849104687 scopus 로고    scopus 로고
    • Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells
    • Kim KK, Lee JJ, Yang Y, You KH, Lee JH. Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells. Carcinogenesis. 2008;29(4):704-712.
    • (2008) Carcinogenesis , vol.29 , Issue.4 , pp. 704-712
    • Kim, K.K.1    Lee, J.J.2    Yang, Y.3    You, K.H.4    Lee, J.H.5
  • 66
    • 77952477287 scopus 로고    scopus 로고
    • Macrophage inhibitory cytokine-1 transactivates ErbB family receptors via the activation of Src in SK-BR-3 human breast cancer cells
    • Park YJ, Lee H, Lee JH. Macrophage inhibitory cytokine-1 transactivates ErbB family receptors via the activation of Src in SK-BR-3 human breast cancer cells. BMB Rep. 2010;43(2):91-96.
    • (2010) BMB Rep , vol.43 , Issue.2 , pp. 91-96
    • Park, Y.J.1    Lee, H.2    Lee, J.H.3
  • 67
    • 33847369020 scopus 로고    scopus 로고
    • Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: Effects on insulin-like growth factor I signaling
    • Nahta R, Yuan LX, Du Y, Esteva FJ. Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling. Mol Cancer Ther. 2007;6(2):667-674.
    • (2007) Mol Cancer Ther , vol.6 , Issue.2 , pp. 667-674
    • Nahta, R.1    Yuan, L.X.2    Du, Y.3    Esteva, F.J.4
  • 68
    • 0037099532 scopus 로고    scopus 로고
    • Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
    • Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S, Arteaga CL. Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res. 2002;62(14):4132-4141.
    • (2002) Cancer Res , vol.62 , Issue.14 , pp. 4132-4141
    • Yakes, F.M.1    Chinratanalab, W.2    Ritter, C.A.3    King, W.4    Seelig, S.5    Arteaga, C.L.6
  • 69
    • 1042291150 scopus 로고    scopus 로고
    • Development of Herceptin resistance in breast cancer cells
    • Kute T, Lack CM, Willingham M, et al. Development of Herceptin resistance in breast cancer cells. Cytometry A. 2004;57(2):86-93.
    • (2004) Cytometry A , vol.57 , Issue.2 , pp. 86-93
    • Kute, T.1    Lack, C.M.2    Willingham, M.3
  • 70
    • 33846216907 scopus 로고    scopus 로고
    • Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2-positive breast cancer cells in a synergistic manner
    • Cardoso F, Durbecq V, Laes JF, et al. Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2-positive breast cancer cells in a synergistic manner. Mol Cancer Ther. 2006; 5(12):3042-3051.
    • (2006) Mol Cancer Ther , vol.5 , Issue.12 , pp. 3042-3051
    • Cardoso, F.1    Durbecq, V.2    Laes, J.F.3
  • 71
    • 54949138880 scopus 로고    scopus 로고
    • Synergic antitumoral effect of an IGF-IR inhibitor and trastuzumab on HER2-overexpressing breast cancer cells
    • Esparís-Ogando A, Ocaña A, Rodríguez-Barrueco R, Ferreira L, Borges J, Pandiella A. Synergic antitumoral effect of an IGF-IR inhibitor and trastuzumab on HER2-overexpressing breast cancer cells. Ann Oncol. 2008;19(11):1860-1869.
    • (2008) Ann Oncol , vol.19 , Issue.11 , pp. 1860-1869
    • Esparís-Ogando, A.1    Ocaña, A.2    Rodríguez-Barrueco, R.3    Ferreira, L.4    Borges, J.5    Pandiella, A.6
  • 72
    • 33751168744 scopus 로고    scopus 로고
    • Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor
    • Tseng PH, Wang YC, Weng SC, et al. Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor. Mol Pharmacol. 2006;70(5):1534-1541.
    • (2006) Mol Pharmacol , vol.70 , Issue.5 , pp. 1534-1541
    • Tseng, P.H.1    Wang, Y.C.2    Weng, S.C.3
  • 73
    • 80052210096 scopus 로고    scopus 로고
    • Targeting Bcl-2 in Herceptin-resistant breast cancer cell lines
    • Crawford A, Nahta R. Targeting Bcl-2 in Herceptin-resistant breast cancer cell lines. Curr Pharmacogenomics Person Med. 2011;9(3): 184-190.
    • (2011) Curr Pharmacogenomics Person Med , vol.9 , Issue.3 , pp. 184-190
    • Crawford, A.1    Nahta, R.2
  • 74
    • 73549101691 scopus 로고    scopus 로고
    • Inhibition of Mcl-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy
    • Martin AP, Mitchell C, Rahmani M, Nephew KP, Grant S, Dent P. Inhibition of Mcl-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy. Cancer Biol Ther. 2009;8(21):2084-2096.
    • (2009) Cancer Biol Ther , vol.8 , Issue.21 , pp. 2084-2096
    • Martin, A.P.1    Mitchell, C.2    Rahmani, M.3    Nephew, K.P.4    Grant, S.5    Dent, P.6
  • 75
    • 33947732465 scopus 로고    scopus 로고
    • Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor
    • Witters LM, Witkoski A, Planas-Silva MD, Berger M, Viallet J, Lipton A. Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor. Oncol Rep. 2007;17(2):465-469.
    • (2007) Oncol Rep , vol.17 , Issue.2 , pp. 465-469
    • Witters, L.M.1    Witkoski, A.2    Planas-Silva, M.D.3    Berger, M.4    Viallet, J.5    Lipton, A.6
  • 76
    • 78649786164 scopus 로고    scopus 로고
    • Oncogenic HER2Δ16 suppresses miR-15a/16 and deregulates Bcl-2 to promote endocrine resistance of breast tumors
    • Cittelly DM, Das PM, Salvo VA, Fonseca JP, Burow ME, Jones FE. Oncogenic HER2Δ16 suppresses miR-15a/16 and deregulates Bcl-2 to promote endocrine resistance of breast tumors. Carcinogenesis. 2010;31(12):2049-2057.
    • (2010) Carcinogenesis , vol.31 , Issue.12 , pp. 2049-2057
    • Cittelly, D.M.1    Das, P.M.2    Salvo, V.A.3    Fonseca, J.P.4    Burow, M.E.5    Jones, F.E.6
  • 77
    • 0029888125 scopus 로고    scopus 로고
    • Overexpression of HER2 modulates Bcl-2, Bcl-XL, and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells
    • Kumar R, Mandal M, Lipton A, Harvey H, Thompson CB. Overexpression of HER2 modulates Bcl-2, Bcl-XL, and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells. Clin Cancer Res. 1996;2(7):1215-1219.
    • (1996) Clin Cancer Res , vol.2 , Issue.7 , pp. 1215-1219
    • Kumar, R.1    Mandal, M.2    Lipton, A.3    Harvey, H.4    Thompson, C.B.5
  • 78
    • 68849092790 scopus 로고    scopus 로고
    • An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance
    • Mitra D, Brumlik MJ, Okamgba SU, et al. An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance. Mol Cancer Ther. 2009;8(8):2152-2162.
    • (2009) Mol Cancer Ther , vol.8 , Issue.8 , pp. 2152-2162
    • Mitra, D.1    Brumlik, M.J.2    Okamgba, S.U.3
  • 79
    • 44049104549 scopus 로고    scopus 로고
    • Expression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide- 3 kinase (PI3K) signalling pathways
    • Siddiqa A, Long LM, Li L, Marciniak RA, Kazhdan I. Expression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide- 3 kinase (PI3K) signalling pathways. BMC Cancer. 2008;8:129.
    • (2008) BMC Cancer , vol.8 , pp. 129
    • Siddiqa, A.1    Long, L.M.2    Li, L.3    Marciniak, R.A.4    Kazhdan, I.5
  • 80
    • 82455175412 scopus 로고    scopus 로고
    • HER2-positive breast cancer cells resistant to trastuzumab and lapatinib lose reliance upon HER2 and are sensitive to the multitargeted kinase inhibitor sorafenib
    • Valabrega G, Capellero S, Cavalloni G, et al. HER2-positive breast cancer cells resistant to trastuzumab and lapatinib lose reliance upon HER2 and are sensitive to the multitargeted kinase inhibitor sorafenib. Breast Cancer Res Treat. 2011;130(1):29-40.
    • (2011) Breast Cancer Res Treat , vol.130 , Issue.1 , pp. 29-40
    • Valabrega, G.1    Capellero, S.2    Cavalloni, G.3
  • 81
    • 0036850211 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1
    • Gojo I, Zhang B, Fenton RG. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin Cancer Res. 2002;8(11):3527-3538.
    • (2002) Clin Cancer Res , vol.8 , Issue.11 , pp. 3527-3538
    • Gojo, I.1    Zhang, B.2    Fenton, R.G.3
  • 82
    • 78549257149 scopus 로고    scopus 로고
    • Inhibition of Mcl-1 in breast cancer cells promotes cell death in vitro and in vivo
    • Mitchell C, Yacoub A, Hossein H, et al. Inhibition of Mcl-1 in breast cancer cells promotes cell death in vitro and in vivo. Cancer Biol Ther. 2010;10(9):903-917.
    • (2010) Cancer Biol Ther , vol.10 , Issue.9 , pp. 903-917
    • Mitchell, C.1    Yacoub, A.2    Hossein, H.3
  • 83
    • 0037089564 scopus 로고    scopus 로고
    • Rate-limiting effects of cyclin D1 in transformation by ErbB2 predicts synergy between Herceptin and flavopiridol
    • Nahta R, Iglehart JD, Kempkes B, Schmidt EV. Rate-limiting effects of cyclin D1 in transformation by ErbB2 predicts synergy between Herceptin and flavopiridol. Cancer Res. 2002;62(8):2267-2271.
    • (2002) Cancer Res , vol.62 , Issue.8 , pp. 2267-2271
    • Nahta, R.1    Iglehart, J.D.2    Kempkes, B.3    Schmidt, E.V.4
  • 84
    • 0037742257 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer
    • Nahta R, Trent S, Yang C, Schmidt EV. Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer. Cancer Res. 2003;63(13):3626-3631.
    • (2003) Cancer Res , vol.63 , Issue.13 , pp. 3626-3631
    • Nahta, R.1    Trent, S.2    Yang, C.3    Schmidt, E.V.4
  • 85
    • 35148885729 scopus 로고    scopus 로고
    • A functional genetic approach identif ies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    • Berns K, Horlings HM, Hennessy BT, et al. A functional genetic approach identif ies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell. 2007;12(4):395-402.
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 395-402
    • Berns, K.1    Horlings, H.M.2    Hennessy, B.T.3
  • 86
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata Y, Lan KH, Zhou X, et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell. 2004;6(2): 117-127.
    • (2004) Cancer Cell , vol.6 , Issue.2 , pp. 117-127
    • Nagata, Y.1    Lan, K.H.2    Zhou, X.3
  • 87
    • 77957352037 scopus 로고    scopus 로고
    • PTEN, PIK3CA, p-AKT, and p-p70S6 K status: Association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer
    • Esteva FJ, Guo H, Zhang S, et al. PTEN, PIK3CA, p-AKT, and p-p70S6 K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. Am J Pathol. 2010;177(4):1647-1656.
    • (2010) Am J Pathol , vol.177 , Issue.4 , pp. 1647-1656
    • Esteva, F.J.1    Guo, H.2    Zhang, S.3
  • 88
    • 35348917266 scopus 로고    scopus 로고
    • Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN def iciency
    • Lu CH, Wyszomierski SL, Tseng LM, et al. Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN def iciency. Clin Cancer Res. 2007;13(19):5883-5888.
    • (2007) Clin Cancer Res , vol.13 , Issue.19 , pp. 5883-5888
    • Lu, C.H.1    Wyszomierski, S.L.2    Tseng, L.M.3
  • 89
    • 75749091464 scopus 로고    scopus 로고
    • In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells
    • Ozbay T, Durden DL, Liu T, O'Regan RM, Nahta R. In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells. Cancer Chemother Pharmacol. 2010;65(4):697-706.
    • (2010) Cancer Chemother Pharmacol , vol.65 , Issue.4 , pp. 697-706
    • Ozbay, T.1    Durden, D.L.2    Liu, T.3    O'Regan, R.M.4    Nahta, R.5
  • 90
    • 78650984926 scopus 로고    scopus 로고
    • Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab
    • Andre F, Campone M, O'Regan R, et al. Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab. J Clin Oncol. 2010;28(34):5110-5115.
    • (2010) J Clin Oncol , vol.28 , Issue.34 , pp. 5110-5115
    • Andre, F.1    Campone, M.2    O'Regan, R.3
  • 91
    • 80051751593 scopus 로고    scopus 로고
    • Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy
    • Morrow PK, Wulf GM, Ensor J, et al. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. J Clin Oncol. 2011;29(23): 3126-3132.
    • (2011) J Clin Oncol , vol.29 , Issue.23 , pp. 3126-3132
    • Morrow, P.K.1    Wulf, G.M.2    Ensor, J.3
  • 92
    • 56449111358 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
    • Eichhorn PJ, Gili M, Scaltriti M, et al. Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res. 2008;68(22):9221-9230.
    • (2008) Cancer Res , vol.68 , Issue.22 , pp. 9221-9230
    • Eichhorn, P.J.1    Gili, M.2    Scaltriti, M.3
  • 93
    • 77953411708 scopus 로고    scopus 로고
    • Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib
    • O'Brien NA, Browne BC, Chow L, et al. Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib. Mol Cancer Ther. 2010;9(6):1489-1502.
    • (2010) Mol Cancer Ther , vol.9 , Issue.6 , pp. 1489-1502
    • O'Brien, N.A.1    Browne, B.C.2    Chow, L.3
  • 94
    • 79958765919 scopus 로고    scopus 로고
    • PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib
    • Wang L, Zhang Q, Zhang J, et al. PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib. BMC Cancer. 2011;11:248.
    • (2011) BMC Cancer , vol.11 , pp. 248
    • Wang, L.1    Zhang, Q.2    Zhang, J.3
  • 95
    • 84856265603 scopus 로고    scopus 로고
    • Pharmacologic inhibition of mTOR improves lapatinib sensitivity in HER2-overexpressing breast cancer cells with primary trastuzumab resistance
    • Gayle SS, Arnold SL, O'Regan RM, Nahta R. Pharmacologic inhibition of mTOR improves lapatinib sensitivity in HER2-overexpressing breast cancer cells with primary trastuzumab resistance. Anticancer Agents Med Chem. 2012;12(2):151-162.
    • (2012) Anticancer Agents Med Chem , vol.12 , Issue.2 , pp. 151-162
    • Gayle, S.S.1    Arnold, S.L.2    O'Regan, R.M.3    Nahta, R.4
  • 96
    • 73649149433 scopus 로고    scopus 로고
    • Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
    • Scheuer W, Friess T, Burtscher H, Bossenmaier B, Endl J, Hasmann M. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res. 2009;69(24):9330-9336.
    • (2009) Cancer Res , vol.69 , Issue.24 , pp. 9330-9336
    • Scheuer, W.1    Friess, T.2    Burtscher, H.3    Bossenmaier, B.4    Endl, J.5    Hasmann, M.6
  • 97
    • 79952276644 scopus 로고    scopus 로고
    • CLEOPATRA: A phase III evaluation of pertuzumab and trastuzumab for HER2-positive metastatic breast cancer
    • Baselga J, Swain SM. CLEOPATRA: a phase III evaluation of pertuzumab and trastuzumab for HER2-positive metastatic breast cancer. Clin Breast Cancer. 2010;10(6):489-491.
    • (2010) Clin Breast Cancer , vol.10 , Issue.6 , pp. 489-491
    • Baselga, J.1    Swain, S.M.2
  • 98
    • 84862894846 scopus 로고    scopus 로고
    • Pertuzumab monotherapy after trastuzumab-based treatment and subsequent reintroduction of trastuzumab: Activity and tolerability in patients with advanced human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol
    • Cortés J, Fumoleau P, Bianchi GV, et al. Pertuzumab monotherapy after trastuzumab-based treatment and subsequent reintroduction of trastuzumab: activity and tolerability in patients with advanced human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol. Epub March 5, 2012.
    • (2012) Epub March , pp. 5
    • Cortés, J.1    Fumoleau, P.2    Bianchi, G.V.3
  • 99
    • 84855297353 scopus 로고    scopus 로고
    • Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): A randomised multicentre, open-label, phase 2 trial
    • Gianni L, Pienkowski T, Im YH, et al. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol. 2012;13(1):25-32.
    • (2012) Lancet Oncol , vol.13 , Issue.1 , pp. 25-32
    • Gianni, L.1    Pienkowski, T.2    Im, Y.H.3
  • 100
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
    • Baselga J, Cortés J, Kim SB, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med. 2012;366(2): 109-119.
    • (2012) N Engl J Med , vol.366 , Issue.2 , pp. 109-119
    • Baselga, J.1    Cortés, J.2    Kim, S.B.3
  • 101
    • 80054092983 scopus 로고    scopus 로고
    • Trastuzumab emtansine: A unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer
    • LoRusso PM, Weiss D, Guardino E, Girish S, Sliwkowski MX. Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer. Clin Cancer Res. 2011;17(20):6437-6447.
    • (2011) Clin Cancer Res , vol.17 , Issue.20 , pp. 6437-6447
    • Lorusso, P.M.1    Weiss, D.2    Guardino, E.3    Girish, S.4    Sliwkowski, M.X.5
  • 102
    • 79959700509 scopus 로고    scopus 로고
    • Trastuzumab- DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
    • Junttila TT, Li G, Parsons K, Phillips GL, Sliwkowski MX. Trastuzumab- DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer. Breast Cancer Res Treat. 2011;128(2):347-356.
    • (2011) Breast Cancer Res Treat , vol.128 , Issue.2 , pp. 347-356
    • Junttila, T.T.1    Li, G.2    Parsons, K.3    Phillips, G.L.4    Sliwkowski, M.X.5
  • 103
    • 56449129810 scopus 로고    scopus 로고
    • Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
    • Lewis Phillips GD, Li G, Dugger DL, et al. Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res. 2008;68(22):9280-9290.
    • (2008) Cancer Res , vol.68 , Issue.22 , pp. 9280-9290
    • Lewis, P.G.D.1    Li, G.2    Dugger, D.L.3
  • 104
    • 77954031486 scopus 로고    scopus 로고
    • Phase I study of trastuzumab- DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer
    • Krop IE, Beeram M, Modi S, et al. Phase I study of trastuzumab- DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. J Clin Oncol. 2010;28(16):2698-2704.
    • (2010) J Clin Oncol , vol.28 , Issue.16 , pp. 2698-2704
    • Krop, I.E.1    Beeram, M.2    Modi, S.3
  • 105
    • 79952092706 scopus 로고    scopus 로고
    • Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
    • Burris HA 3rd, Rugo HS, Vukelja SJ, et al. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol. 2011;29(4):398-405.
    • (2011) J Clin Oncol , vol.29 , Issue.4 , pp. 398-405
    • Burris III, H.A.1    Rugo, H.S.2    Vukelja, S.J.3
  • 107
    • 84855176565 scopus 로고    scopus 로고
    • Responses to subsequent anti-HER2 therapy after treatment with trastuzumab-DM1 in women with HER2-positive metastatic breast cancer
    • Olson EM, Lin NU, DiPiro PJ, et al. Responses to subsequent anti-HER2 therapy after treatment with trastuzumab-DM1 in women with HER2-positive metastatic breast cancer. Ann Oncol. 2012;23(1):93-97.
    • (2012) Ann Oncol , vol.23 , Issue.1 , pp. 93-97
    • Olson, E.M.1    Lin, N.U.2    Dipiro, P.J.3
  • 108
    • 2542582261 scopus 로고    scopus 로고
    • Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase
    • Rabindran SK, Discafani CM, Rosfjord EC, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res. 2004;64(11):3958-3965.
    • (2004) Cancer Res , vol.64 , Issue.11 , pp. 3958-3965
    • Rabindran, S.K.1    Discafani, C.M.2    Rosfjord, E.C.3
  • 109
    • 34250766250 scopus 로고    scopus 로고
    • Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles
    • Hegde PS, Rusnak D, Bertiaux M, et al. Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles. Mol Cancer Ther. 2007;6(5):1629-1640.
    • (2007) Mol Cancer Ther , vol.6 , Issue.5 , pp. 1629-1640
    • Hegde, P.S.1    Rusnak, D.2    Bertiaux, M.3
  • 110
    • 84862525436 scopus 로고    scopus 로고
    • Differential action of small molecule HER kinase inhibitors on receptor heterodimerization: Therapeutic implications
    • Epub August 8, 2011
    • Sánchez-Martín M, Pandiella A. Differential action of small molecule HER kinase inhibitors on receptor heterodimerization: therapeutic implications. Int J Cancer. 2011. Epub August 8, 2011.
    • (2011) Int J Cancer
    • Sánchez-Martín, M.1    Pandiella, A.2
  • 111
    • 79956077600 scopus 로고    scopus 로고
    • A genome-wide RNAi screen identifies novel targets of neratinib sensitivity leading to neratinib and paclitaxel combination drug treatments
    • Seyhan AA, Varadarajan U, Choe S, et al. A genome-wide RNAi screen identifies novel targets of neratinib sensitivity leading to neratinib and paclitaxel combination drug treatments. Mol Biosyst. 2011;7(6):1974-1989.
    • (2011) Mol Biosyst , vol.7 , Issue.6 , pp. 1974-1989
    • Seyhan, A.A.1    Varadarajan, U.2    Choe, S.3
  • 112
    • 77950497981 scopus 로고    scopus 로고
    • Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2- positive breast cancer
    • Burstein HJ, Sun Y, Dirix LY, et al. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2- positive breast cancer. J Clin Oncol. 2010;28(8):1301-1307.
    • (2010) J Clin Oncol , vol.28 , Issue.8 , pp. 1301-1307
    • Burstein, H.J.1    Sun, Y.2    Dirix, L.Y.3
  • 113
    • 65249170861 scopus 로고    scopus 로고
    • A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors
    • Wong KK, Fracasso PM, Bukowski RM, et al. A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors. Clin Cancer Res. 2009;15(7):2552-2558.
    • (2009) Clin Cancer Res , vol.15 , Issue.7 , pp. 2552-2558
    • Wong, K.K.1    Fracasso, P.M.2    Bukowski, R.M.3
  • 114
    • 70349696649 scopus 로고    scopus 로고
    • Affitoxin: A novel recombinant, HER2-specific, anticancer agent for targeted therapy of HER2-positive tumors
    • Zielinski R, Lyakhov I, Jacobs A, et al. Affitoxin: a novel recombinant, HER2-specific, anticancer agent for targeted therapy of HER2-positive tumors. J Immunother. 2009;32(8):817-825.
    • (2009) J Immunother , vol.32 , Issue.8 , pp. 817-825
    • Zielinski, R.1    Lyakhov, I.2    Jacobs, A.3
  • 115
    • 79961003260 scopus 로고    scopus 로고
    • HER2-affitoxin: A potent therapeutic agent for the treatment of HER2-overexpressing tumors
    • Zielinski R, Lyakhov I, Hassan M, et al. HER2-affitoxin: a potent therapeutic agent for the treatment of HER2-overexpressing tumors. Clin Cancer Res. 2011;17(15):5071-5081.
    • (2011) Clin Cancer Res , vol.17 , Issue.15 , pp. 5071-5081
    • Zielinski, R.1    Lyakhov, I.2    Hassan, M.3


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