Positive allosteric modulators differentially affect full versus partial agonist activation of the glycine receptor

Journal of Pharmacology and Experimental Therapeutics

Volumn 342, Issue 1, 2012, Pages 61-70

  Kirson, Dean ^a   Todorovic, Jelena ^a   Mihic, S John ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1,1 TRICHLOROETHANE; ALCOHOL; CHLOROFORM; DESFLURANE; ENFLURANE; GLYCINE; GLYCINE RECEPTOR; HALOTHANE; ISOFLURANE; TAURINE; TOLUENE; TRICHLOROETHYLENE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ALLOSTERIC REGULATION; ANESTHETICS; ANIMALS; DRUG PARTIAL AGONISM; ETHANOL; GLYCINE; OOCYTES; RECEPTORS, GLYCINE; TAURINE; XENOPUS LAEVIS;

EID: 84862489415     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.191486     Document Type: Article

References (39)

1. Albrecht J and Schousboe A (2005) Taurine interaction with neurotransmitter receptors in the CNS: an update. Neurochem Res 30:1615-1621. (Pubitemid 41813726)
2. Baer K, Waldvogel HJ, Faull RL, and Rees MI (2009) Localization of glycine receptors in the human forebrain, brainstem, and cervical spinal cord: an immunohistochemical review. Front Mol Neurosci 2:25.
3. Beato M, Groot-Kormelink PJ, Colquhoun D, and Sivilotti LG (2004) The activation mechanism of alpha1 homomeric glycine receptors. J Neurosci 24:895-906. (Pubitemid 38146600)
4. Beckstead MJ, Weiner JL, Eger EI 2nd, Gong DH, and Mihic SJ (2000) Glycine and gamma-aminobutyric acidA receptor function is enhanced by inhaled drugs of abuse. Mol Pharmacol 57:1199-1205. (Pubitemid 30354392)
5. Beckstead MJ, Phelan R, and Mihic SJ (2001) Antagonism of inhalant and volatile anesthetic enhancement of glycine receptor function. J Biol Chem 276:24959-24964.
6. Beckstead MJ, Phelan R, Trudell JR, Bianchini MJ, and Mihic SJ (2002) Anesthetic and ethanol effects on spontaneously opening glycine receptor channels. J Neurochem 82:1343-1351.
7. Bowen SE, Batis JC, Paez-Martinez N, and Cruz SL (2006) The last decade of solvent research in animal models of abuse: mechanistic and behavioral studies. Neurotoxicol Teratol 28:636-647. (Pubitemid 44829925)
8. Chau PL (2010) New insights into the molecular mechanisms of general anaesthetics. Br J Pharmacol 161:288-307.
9. Cheng G and Kendig JJ (2002) Pre- and postsynaptic volatile anaesthetic actions on glycinergic transmission to spinal cord motor neurons. Br J Pharmacol 136:673-684. (Pubitemid 34785709)
10. Colman A (1984) Expression of exogenous DNA in Xenopus oocytes, in Transcription and Translation: A Practical Approach (Hames BD, Higgins SJ eds) pp 49-69, Oxford Press, Washington, DC.
11. Dahchour A, Quertemont E, and De Witte P (1996) Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naïve and chronically alcoholised rats. Brain Res 735:9-19. (Pubitemid 26336614)
12. Downie DL, Hall AC, Lieb WR, and Franks NP (1996) Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurons and recombinant glycine receptors in Xenopus oocytes. Br J Pharmacol 118:493-502. (Pubitemid 26180962)
13. Ericson M, Molander A, Stomberg R, and Söderpalm B (2006) Taurine elevates dopamine levels in the rat nucleus accumbens: antagonism by strychnine. Eur J Neurosci 23:3225-3229.
14. Ericson M, Chau P, Clarke RB, Adermark L, and Söderpalm B (2011) Rising taurine and ethanol concentrations in nucleus accumbens interact to produce dopamine release after ethanol administration. Addict Biol 16:377-385.
15. Evans EB and Balster RL (1991) CNS depressant effects of volatile organic solvents. Neurosci Biobehav Rev 15:233-241.
16. Franks NP (2008) General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 9:370-386.
17. Gardner P, Ogden DC, and Colquhoun D (1984) Conductances of single ion channels opened by nicotinic agonists are indistinguishable. Nature 309:160-162. (Pubitemid 14142786)
18. Lape R, Colquhoun D, and Sivilotti LG (2008) On the nature of partial agonism in the nicotinic receptor superfamily. Nature 454:722-727.
19. Lewis TM, Schofield PR, and McClellan AM (2003) Kinetic determinants of agonist action at the recombinant human glycine receptor. J Physiol 549:361-374. (Pubitemid 36701750)
20. Lu Y and Ye JH (2011) Glycine-activated chloride currents of neurons freshly isolated from the prefrontal cortex of young rats. Brain Res 1393:17-22.
21. Lubman DI, Yücel M, and Lawrence AJ (2008) Inhalant abuse among adolescents: neurobiological considerations. Br J Pharmacol 154:316-326. (Pubitemid 351670602)
22. Lynch JW (2004) Molecular structure and function of the glycine receptor chloride channel. Physiol Rev 84:1051-1095.
23. Mascia MP, Mihic SJ, Valenzuela CF, Schofield PR, and Harris RA (1996) A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors. Mol Pharmacol 50:402-406. (Pubitemid 26265146)
24. Mihic SJ, McQuilkin SJ, Eger EI 2nd, Ionescu P, and Harris RA (1994) Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia. Mol Pharmacol 46:851-857. (Pubitemid 24364096)
25. Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, et al. (1997) Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature 389:385-389. (Pubitemid 27415220)
26. Mihic SJ (1999) Acute effects of ethanol on GABAA and glycine receptor function. Neurochem Int 35:115-123.
27. Molander A, Löf E, Stomberg R, Ericson M, and Söderpalm B (2005) Involvement of accumbal glycine receptors in the regulation of voluntary ethanol intake in the rat. Alcohol Clin Exp Res 29:38-45. (Pubitemid 40129209)
28. Molander A, Lidö HH, Löf E, Ericson M, and Söderpalm B (2007) The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats. Alcohol Alcohol 42:11-18. (Pubitemid 46062634)
29. Mori M, Gähwiler BH, and Gerber U (2002) Beta-alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro. J Physiol 539:191-200. (Pubitemid 35190107)
30. Roberts MT, Phelan R, Erlichman BS, Pillai RN, Ma L, Lopreato GF, and Mihic SJ (2006) Occupancy of a single anesthetic binding pocket is sufficient to enhance glycine receptor function. J Biol Chem 281:3305-3311. (Pubitemid 43845944)
31. Rodríguez-Navarro JA, Gonzalo-Gobernado R, Herranz AS, Gonźlez-Vigueras JM, and Solís JM (2009) High potassium induces taurine release by osmosensitive and osmoresistant mechanisms in the rat hippocampus in vivo. J Neurosci Res 87:208-217.
32. Shibanoki S, Kogure M, Sugahara M, and Ishikawa K (1993) Effect of systemic administration of N-methyl-D-aspartic acid on extracellular taurine level measured by microdialysis in the hippocampal CA1 field and striatum of rats. J Neurochem 61:1698-1704. (Pubitemid 23317192)
33. Wang F, Xiao C, and Ye JH (2005) Taurine activates excitatory non-synaptic glycine receptors on dopamine neurones in ventral tegmental area of young rats. J Physiol 565:503-516. (Pubitemid 40872478)
34. Welsh BT, Goldstein BE, and Mihic SJ (2009) Single-channel analysis of ethanol enhancement of glycine receptor function. J Pharmacol Exp Ther 330:198-205.
35. Welsh BT, Kirson D, Allen HM, and Mihic SJ (2010) Ethanol enhances taurine-activated glycine receptor function. Alcohol Clin Exp Res 34:1634-1639.
36. Yamakura T, Mihic SJ, and Harris RA (1999) Amino acid volume and hydropathy of a transmembrane site determine glycine and anesthetic sensitivity of glycine receptors. J Biol Chem 274:23006-23012.
37. Yamashita M, Ueno T, Akaike N, and Ikemoto Y (2001) Modulation of miniature inhibitory postsynaptic currents by isoflurane in rat dissociated neurons with glycinergic synaptic boutons. Eur J Pharmacol 431:269-276. (Pubitemid 33145403)
38. Ye Q, Koltchine VV, Mihic SJ, Mascia MP, Wick MJ, Finn SE, Harrison NL, and Harris RA (1998) Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267. J Biol Chem 273:3314-3319. (Pubitemid 28109745)
39. Yevenes GE and Zeilhofer HU (2011) Allosteric modulation of glycine receptors. Br J Pharmacol 164:224-236.