Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2- oxocyclopentyl)methyl]phenyl}propanoic acid: Nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity

Journal of Medicinal Chemistry

Volumn 55, Issue 11, 2012, Pages 5143-5150

  Yamakawa, Naoki ^a,b   Suemasu, Shintaro ^a   Okamoto, Yoshinari ^b   Tanaka, Ken Ichiro ^b   Ishihara, Tomoaki ^a   Asano, Teita ^a   Miyata, Keishi ^b   Otsuka, Masami ^b   Mizushima, Tohru ^a  

^a KEIO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (CYCLOPENTYLAMINO) 2 FLUOROPHENYL]PROPANOIC ACID; CARRAGEENAN; CYCLOOXYGENASE 2; LOXOPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PRODRUG; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; FOOT EDEMA; HUMAN; HUMAN TISSUE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ULCEROGENESIS;

ANILINE COMPOUNDS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; EDEMA; HUMANS; PHENYLPROPIONATES; RATS; STOMACH ULCER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862297367     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300049g     Document Type: Article

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