Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer

Nature Chemical Biology

Volumn 6, Issue 12, 2010, Pages 887-889

  Jenkins, Lisa M Miller ^a   Ott, David E ^b   Hayashi, Ryo ^a   Coren, Lori V ^b   Wang, Deyun ^c   Xu, Qun ^c   Schito, Marco L ^a,e   Inman, John K ^d   Appella, Daniel H ^c   Appella, Ettore ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CELL ENZYME; GAG PROTEIN; NCP7 PROTEIN; NUCLEOCAPSID PROTEIN; PRODRUG; S ACYL 2 MERCAPTOBENZAMIDE THIOESTER 247; THIOESTER; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ACETYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CYTOTOXICITY; DRUG TARGETING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOBLOTTING; IN VITRO STUDY; INTRACELLULAR MEMBRANE; MOLECULE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN PURIFICATION; VIRION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 78649318706     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.456     Document Type: Article

References (24)

1. Rahim, S., Fredrick, L. M., da Silva, B. A., Bernstein, B. & King, M. S. HIV Clin. Trials 10, 94-103 (2009).
2. Sprinz, E. et al. AIDS Res. Hum. Retroviruses 25, 861-867 (2009).
3. Wheeler, W. H. et al. AIDS 24, 1203-1212 (2010).
4. De Rocquigny, H. et al. Mini Rev. Med. Chem. 8, 24-35 (2008).
5. Goldschmidt, V., Miller Jenkins, L. M., De Rocquigny, H., Darlix, J. L. & Mely, Y. HIV Therapy 4, 179-198 (2010).
6. Coffin, J. M., Hughes, S. H. & Varmus, H. E. (eds.) Retroviruses 843 (Cold Spring Harbor Laboratory Press, 1997).
7. Miller Jenkins, L. M. et al. J. Am. Chem. Soc. 129, 11067-11078 (2007).
8. Thomas, J. A. & Gorelick, R. J. Virus Res. 134, 39-63 (2008).
9. Turpin, J. A. et al. J. Virol. 70, 6180-6189 (1996).
10. Yovandich, J. L. et al. J. Virol. 75, 115-124 (2001).
11. Darlix, J. L., Garrido, J. L., Morellet, N., Mely, Y. & de Rocquigny, H. Adv. Pharmacol. 55, 299-346 (2007).
12. Turpin, J. A., Schito, M. L., Jenkins, L. M., Inman, J. K. & Appella, E. Adv. Pharmacol. 56, 229-256 (2008).
13. Miller Jenkins, L. M. et al. J. Med. Chem. 48, 2847-2858 (2005).
14. Srivastava, P. et al. Bioorg. Med. Chem. 12, 6437-6450 (2004).
15. Jenkins, L. M. M. et al. J. Am. Chem. Soc. 128, 11964-11976 (2006).
16. Schito, M. L. et al. AIDS Res. Hum. Retroviruses 19, 91-101 (2003).
17. Wallace, G. S. et al. J. Virol. 83, 9175-9182 (2009).
18. Turpin, J. A. et al. J. Med. Chem. 42, 67-86 (1999).
19. Hosokawa, M. Molecules 13, 412-431 (2008).
20. Kaplan, A. H. et al. J. Virol. 67, 4050-4055 (1993).
21. Müller, B. et al. J. Biol. Chem. 284, 29692-29703 (2009).
22. Turpin, J. A. Expert Rev. Anti Infect. Ther. 1, 97-128 (2003).
23. Rustin, P. et al. Biochim. Biophys. Acta 1361, 185-197 (1997).
24. Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Science 324, 1029-1033 (2009).