Role of pigment epithelium-derived factor in stem/progenitor cell-associated neovascularization

Journal of Biomedicine and Biotechnology

Volumn 2012, Issue , 2012, Pages

  Liu, Jung Tung ^a   Chen, Yuh Lien ^b   Chen, Wen Chi ^c,d   Chen, Huey Yi ^c,d   Lin, Yi Wen ^c   Wang, Shu Huei ^b   Man, Kee Ming ^e   Wan, Hui Min ^f   Yin, Wei Hsian ^g   Liu, Po Len ^f   Chen, Yung Hsiang ^c,d  

^a CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e TUNGS' TAICHUNG METROHARBOR HOSPITAL   (Taiwan)

^f KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^g NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; PIGMENT EPITHELIUM DERIVED FACTOR; EYE PROTEIN; NERVE GROWTH FACTOR; PIGMENT EPITHELIUM-DERIVED FACTOR; SERINE PROTEINASE INHIBITOR;

ANGIOGENESIS; BLINDNESS; CARDIOVASCULAR DISEASE; HUMAN; NEOVASCULARIZATION (PATHOLOGY); PATHOGENESIS; RETINA NEOVASCULARIZATION; REVIEW; STEM CELL; SUBRETINAL NEOVASCULARIZATION; ANIMAL; CYTOLOGY; PHYSIOLOGY;

ANIMALS; EYE PROTEINS; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; NERVE GROWTH FACTORS; SERPINS; STEM CELLS;

EID: 84862289268     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2012/871272     Document Type: Review

References (95)

1. Tombran-Tink J., Johnson L. V., Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells Investigative Ophthalmology and Visual Science 1989 30 8 1700 1707 (Pubitemid 19214990)
2. Steele F. R., Chader G. J., Johnson L. V., Tombran-Tink J., Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family Proceedings of the National Academy of Sciences of the United States of America 1993 90 4 1526 1530 (Pubitemid 23058206)
3. Ek E. T. H., Dass C. R., Choong P. F. M., PEDF: a potential molecular therapeutic target with multiple anti-cancer activities Trends in Molecular Medicine 2006 12 10 497 502 (Pubitemid 44468197)
4. Rychli K., Huber K., Wojta J., Pigment epithelium-derived factor (PEDF) as a therapeutic target in cardiovascular disease Expert Opinion on Therapeutic Targets 2009 13 11 1295 1302
5. Tombran-Tink J., Chader G. G., Johnson L. V., PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity[2] Experimental Eye Research 1991 53 3 411 414
6. Bilak M. M., Corse A. M., Bilak S. R., Lehar M., Tombran-Tink J., Kuncl R. W., Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration Journal of Neuropathology and Experimental Neurology 1999 58 7 719 728 (Pubitemid 29328501)
7. DeCoster M. A., Schabelman E., Tombran-Tink J., Neuroprotection by pigment epithelial-derived factor against glutamate toxicity in developing primary hippocampal neurons Journal of Neuroscience Research 1999 56 6 604 610 (Pubitemid 29246842)
8. Falk T., Zhang S., Sherman S. J., Pigment epithelium derived factor (PEDF) is neuroprotective in two in vitro models of Parkinson's disease Neuroscience Letters 2009 458 2 49 52
9. Sanagi T., Yabe T., Yamada H., Adenoviral gene delivery of pigment epithelium-derived factor protects striatal neurons from quinolinic acid-induced excitotoxicity Journal of Neuropathology and Experimental Neurology 2010 69 3 224 233
10. Dawson D. W., Volpert O. V., Gillis P., Crawford S. E., Xu H. J., Benedict W., Bouck N. P., Pigment epithelium-derived factor: a potent inhibitor of angiogenesis Science 1999 285 5425 245 248 (Pubitemid 29329995)
11. Levy E. M., Roberti M. P., Mordoh J., Natural killer cells in human cancer: from biological functions to clinical applications Journal of Biomedicine and Biotechnology 2011 2011 11
12. Zhang S. X., Wang J. J., Gao G., Shao C., Mott R., Ma J. X., Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor FASEB Journal 2006 20 2 323 325 (Pubitemid 46671158)
13. Yamagishi S. I., Nakamura K., Ueda S., Kato S., Imaizumi T., Pigment epithelium-derived factor (PEDF) blocks angiotensin II signaling in endothelial cells via suppression of NADPH oxidase: a novel anti-oxidative mechanism of PEDF Cell and Tissue Research 2005 320 3 437 445 (Pubitemid 40884145)
14. Wang S. H., Lin S. J., Chen Y. H., Lin F. Y., Shih J. C., Wu C. C., Wu H. L., Chen Y. L., Late outgrowth endothelial cells derived from wharton jelly in human umbilical cord reduce neointimal formation after vascular injury: involvement of pigment epithelium-derived factor Arteriosclerosis, Thrombosis, and Vascular Biology 2009 29 6 816 822
15. Tombran-Tink J., PEDF in angiogenic eye diseases Current Molecular Medicine 2010 10 3 267 278
16. Funatsu H., Yamashita H., Nakamura S., Mimura T., Eguchi S., Noma H., Hori S., Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor are related to diabetic macular edema Ophthalmology 2006 113 2 294 301 (Pubitemid 43170779)
17. Doll J. A., Stellmach V. M., Bouck N. P., Bergh A. R. J., Lee C., Abramson L. P., Cornwell M. L., Pins M. R., Borensztajn J., Crawford S. E., Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas Nature Medicine 2003 9 6 774 780 (Pubitemid 36749229)
18. Hase R., Miyamoto M., Uehara H., Kadoya M., Ebihara Y., Murakami Y., Takahashi R., Mega S., Li L., Shichinohe T., Kawarada Y., Kondo S., Pigment epithelium-derived factor gene therapy inhibits human pancreatic cancer in mice Clinical Cancer Research 2005 11 24 8737 8744 (Pubitemid 43005924)
19. Filleur S., Volz K., Nelius T., Mirochnik Y., Huang H., Zaichuk T. A., Aymerich M. S., Becerra S. P., Yap R., Veliceasa D., Shroff E. H., Volpert O. V., Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer Cancer Research 2005 65 12 5144 5152 (Pubitemid 40827323)
20. Abe R., Fujita Y., Yamagishi S. I., Shimizu H., Pigment epithelium-derived factor prevents melanoma growth via angiogenesis inhibition Current Pharmaceutical Design 2008 14 36 3802 3809
21. George A. L., Bangalore-Prakash P., Rajoria S., Suriano R., Shanmugam A., Mittelman A., Tiwari R. K., Endothelial progenitor cell biology in disease and tissue regeneration Journal of Hematology and Oncology 2011 4, article 24
22. Matthias M., David N., Josef N., From bench to bedside: what physicians need to know about endothelial progenitor cells American Journal of Medicine 2011 124 6 489 497
23. Roks A. J., Rodgers K., Walther T., Effects of the renin angiotensin system on vasculogenesis-related progenitor cells Current Opinion in Pharmacology 2011 11 2 162 174
24. Fang S., Salven P., Stem cells in tumor angiogenesis Journal of Molecular and Cellular Cardiology 2011 50 2 290 295
25. Longeras R., Farjo K., Ihnat M., A PEDF-derived peptide inhibits retinal neovascularization and blocks mobilization of bone marrow-derived endothelial progenitor cells Experimental Diabetes Research 2012 2012 11
26. Thompson W. D., Li W. W., Maragoudakis M., The clinical manipulation of angiogenesis: pathology, side-effects, surprises, and opportunities with novel human therapies The Journal of Pathology 2000 190 3 330 337 (Pubitemid 30141378)
27. Isner J. M., Asahara T., Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization Journal of Clinical Investigation 1999 103 9 1231 1236 (Pubitemid 29218292)
28. Patel-Hett S., D'Amore P. A., Signal transduction in vasculogenesis and developmental angiogenesis International Journal of Developmental Biology 2011 55 4-5 353 369
29. Huang P. H., Chen Y. H., Tsai H. Y., Chen J. S., Wu T. C., Lin F. Y., Sata M., Chen J. W., Lin S. J., Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability Arteriosclerosis, Thrombosis, and Vascular Biology 2010 30 4 869 877
30. Lu J., Pompili V. J., Das H., Neovascularization and hematopoietic stem cells. Cell Biochemistry and Biophysics. In press
31. Grant M. B., May W. S., Caballero S., Brown G. A. J., Guthrie S. M., Mames R. N., Byrne B. J., Vaught T., Spoerri P. E., Peck A. B., Scott E. W., Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization Nature Medicine 2002 8 6 607 612 (Pubitemid 34633439)
32. Rafii S., Lyden D., Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration Nature Medicine 2003 9 6 702 712 (Pubitemid 36749219)
33. Rajantie I., Ilmonen M., Alminaite A., Ozerdem U., Alitalo K., Salven P., Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells Blood 2004 104 7 2084 2086 (Pubitemid 39297861)
34. Peters B. A., Diaz L. A., Polyak K., Meszler L., Romans K., Guinan E. C., Antin J. H., Myerson D., Hamilton S. R., Vogelstein B., Kinzler K. W., Lengauer C., Contribution of bone marrow-derived endothelial cells to human tumor vasculature Nature Medicine 2005 11 3 261 262 (Pubitemid 40460552)
35. Napoli C., Hayashi T., Cacciatore F., Casamassimi A., Casini C., Al-Omran M., Ignarro L. J., Endothelial progenitor cells as therapeutic agents in the microcirculation: an update Atherosclerosis 2011 215 1 9 22
36. Rehman J., Li J., Orschell C. M., March K. L., Peripheral blood endothelial progenitor cells are derived from monocyte/macrophages and secrete angiogenic growth factors Circulation 2003 107 8 1164 1169 (Pubitemid 36297209)
37. Ziegelhoeffer T., Fernandez B., Kostin S., Heil M., Voswinckel R., Helisch A., Schaper W., Bone marrow-derived cells do not incorporate into the adult growing vasculature Circulation Research 2004 94 2 230 238 (Pubitemid 38197456)
38. Urbich C., Aicher A., Heeschen C., Dernbach E., Hofmann W. K., Zeiher A. M., Dimmeler S., Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells Journal of Molecular and Cellular Cardiology 2005 39 5 733 742 (Pubitemid 41464410)
39. Hur J., Yoon C. H., Kim H. S., Choi J. H., Kang H. J., Hwang K. K., Oh B. H., Lee M. M., Park Y. B., Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis Arteriosclerosis, Thrombosis, and Vascular Biology 2004 24 2 288 293 (Pubitemid 38197580)
40. Chen Y. H., Lin S. J., Lin F. Y., Wu T. C., Tsao C. R., Huang P. H., Liu P. L., Chen Y. L., Chen J. W., High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms Diabetes 2007 56 6 1559 1568
41. Asahara T., Masuda H., Takahashi T., Kalka C., Pastore C., Silver M., Kearne M., Magner M., Isner J. M., Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization Circulation Research 1999 85 3 221 228 (Pubitemid 29377293)
42. Ii M., Nishimura H., Iwakura A., Wecker A., Eaton E., Asahara T., Losordo D. W., Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via imported nitric oxide synthase activity Circulation 2005 111 9 1114 1120 (Pubitemid 40365471)
43. Bauer S. M., Goldstein L. J., Bauer R. J., Chen H., Putt M., Velazquez O. C., The bone marrow-derived endothelial progenitor cell response is impaired in delayed wound healing from ischemia Journal of Vascular Surgery 2006 43 1 134 141 (Pubitemid 43083521)
44. Masuda H., Kalka C., Takahashi T., Yoshida M., Wada M., Kobori M., Itoh R., Iwaguro H., Eguchi M., Iwami Y., Tanaka R., Nakagawa Y., Sugimoto A., Ninomiya S., Hayashi S., Kato S., Asahara T., Estrogen-mediated endothelial progenitor cell biology and kinetics for physiological postnatal vasculogenesis Circulation Research 2007 101 6 598 606 (Pubitemid 351325877)
45. Murayama T., Tepper O. M., Silver M., Ma H., Losordo D. W., Isner J. M., Asahara T., Kalka C., Determination of bone marrow-derived endothelial progenitor cell significance in angiogenic growth factor-induced neovascularization in vivo Experimental Hematology 2002 30 8 967 972 (Pubitemid 34838899)
46. Moldovan N. I., Asahara T., Role of blood mononuclear cells in recanalization and vascularization of thrombi: past, present, and future Trends in Cardiovascular Medicine 2003 13 7 265 269 (Pubitemid 37159390)
47. Folkman J., Shing Y., Angiogenesis Journal of Biological Chemistry 1992 267 16 10931 10934
48. Jujo K., Ii M., Losordo D. W., Endothelial progenitor cells in neovascularization of infarcted myocardium Journal of Molecular and Cellular Cardiology 2008 45 4 530 544
49. Asahara T., Kawamoto A., Masuda H., Concise review: circulating endothelial progenitor cells for vascular medicine Stem Cells 2011 29 11 1650 1655
50. Arnhold S., Heiduschka P., Klein H., Absenger Y., Basnaoglu S., Kreppel F., Renke-Fahle S., Kochanek S., Bartz-Schmidt K. U., Addicks K., Schraermeyer U., Adenovirally transduced bone marrow stromal cells differentiate into pigment epithelial cells and induce rescue effects in RCS rats Investigative Ophthalmology and Visual Science 2006 47 9 4121 4129 (Pubitemid 46044331)
51. Karl M. O., Reh T. A., Regenerative medicine for retinal diseases: activating endogenous repair mechanisms Trends in Molecular Medicine 2010 16 4 193 202
52. Gaillard F., Sauvé Y., Cell-based therapy for retina degeneration: the promise of a cure Vision Research 2007 47 22 2815 2824 (Pubitemid 47430169)
53. Caputo M., Zirpoli H., Di Benedetto R., De Nadai K., Tecce M. F., Perspectives of choroidal neovascularization therapy Current Drug Targets 2011 12 2 234 242
54. Chan-Ling T., Dahlstrom J. E., Koina M. E., McColm J. R., Sterling R. A., Bean E. G., Adamson S., Hughes S., Baxter L. C., Evidence of hematopoietic differentiation, vasculogenesis and angiogenesis in the formation of human choroidal blood vessels Experimental Eye Research 2011 92 5 361 376
55. Hou H. Y., Liang H. L., Wang Y. S., Zhang Z. X., Wang B. R., Shi Y. Y., Dong X., Cai Y., A therapeutic strategy for choroidal neovascularization based on recruitment of mesenchymal stem cells to the sites of lesions Molecular Therapy 2010 18 10 1837 1845
56. De Marzo A., Aruta C., Marigo V., PEDF promotes retinal neurosphere formation and expansion in vitro Advances in Experimental Medicine and Biology 2010 664 621 630
57. Aruta C., Giordano F., De Marzo A., Comitato A., Raposo G., Nandrot E. F., Marigo V., In vitro differentiation of retinal pigment epithelium from adult retinal stem cells Pigment Cell and Melanoma Research 2011 24 1 233 240
58. Zhu D., Deng X., Spee C., Sonoda S., Hsieh C. L., Barron E., Pera M., Hinton D. R., Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival Investigative Ophthalmology and Visual Science 2011 52 3 1573 1585
59. Vaajasaari H., Ilmarinen T., Juuti-Uusitalo K., Rajala K., Onnela N., Narkilahti S., Suuronen R., Hyttinen J., Uusitalo H., Skottman H., Toward the defined and xeno-free differentiation of functional human pluripotent stem cell-derived retinal pigment epithelial cells Molecular Vision 2011 17 558 575
60. Yamagishi S. I., Matsui T., Nakamura K., Ueda S., Noda Y., Imaizumi T., Pigment epithelium-derived factor (PEDF): its potential therapeutic implication in diabetic vascular complications Current drug targets 2008 9 11 1025 1029
61. Chang C. H., Tsai C. S., Jim Y. F., Wu H. C., Lin C. C., Kao A., Lumbar bone mineral density in prostate cancer patients with bone metastases Endocrine Research 2003 29 2 177 182 (Pubitemid 36828489)
62. Zhao Y., Bao Q., Renner A., Camaj P., Eichhorn M., Ischenko I., Angele M., Kleespies A., Jauch K. W., Bruns C., Cancer stem cells and angiogenesis International Journal of Developmental Biology 2011 55 4-5 477 482
63. Yao X. H., Ping Y. F., Bian X. W., Contribution of cancer stem cells to tumor vasculogenic mimicry Protein and Cell 2011 2 4 266 272
64. Fan W., Crawford R., Xiao Y., The ratio of VEGF/PEDF expression in bone marrow mesenchymal stem cells regulates neovascularization Differentiation 2011 81 3 181 191
65. Manalo K. B., Choong P. F., Dass C. R., Pigment epithelium-derived factor as an impending therapeutic agent against vascular epithelial growth factor-driven tumor-angiogenesis Molecular Carcinogenesis 2011 50 2 67 72
66. Elzaouk L., Moelling K., Pavlovic J., Anti-tumor activity of mesenchymal stem cells producing IL-12 in a mouse melanoma model Experimental Dermatology 2006 15 11 865 874 (Pubitemid 44473325)
67. Gao P., Ding Q., Wu Z., Jiang H., Fang Z., Therapeutic potential of human mesenchymal stem cells producing IL-12 in a mouse xenograft model of renal cell carcinoma Cancer Letters 2010 290 2 157 166
68. Fitzgerald D. P., Subramanian P., Deshpande M., Opposing effects of pigment epithelium-derived factor on breast cancer cell versus neuronal survival: implication for brain metastasis and metastasis-induced brain damage Cancer Research 2012 72 1 144 153
69. Gao Y., Yao A., Zhang W., Lu S., Yu Y., Deng L., Yin A., Xia Y., Sun B., Wang X., Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice Oncogene 2010 29 19 2784 2794
70. Ping Y. F., Bian X. W., Consice review: contribution of cancer stem cells to neovascularization Stem Cells 2011 29 6 888 894
71. Zhang L. Z., Zhang C. Q., Yan Z. Y., Yang Q. C., Jiang Y., Zeng B. F., Tumor-initiating cells and tumor vascularization Pediatric Blood and Cancer 2011 56 3 335 340
72. Chen J. W., Chen Y. H., Lin S. J., Long-term exposure to oxidized low-density lipoprotein enhances tumor necrosis factor- -stimulated endothelial adhesiveness of monocytes by activating superoxide generation and redox-sensitive pathways Free Radical Biology and Medicine 2006 40 5 817 826
73. Tsai C. S., Lin F. Y., Chen Y. H., Yang T. L., Wang H. J., Huang G. S., Lin C. Y., Tsai Y. T., Lin S. J., Li C. Y., Cilostazol attenuates MCP-1 and MMP-9 expression in vivo in LPS-administrated balloon-injured rabbit aorta and in vitro in LPS-treated monocytic THP-1 cells Journal of Cellular Biochemistry 2008 103 1 54 66
74. Chen Y. H., Lin S. J., Chen Y. L., Liu P. L., Chen J. W., Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules Cardiovascular and Hematological Disorders 2006 6 4 279 304
75. Wu C. H., Tsai B. R., Hsieh W. T., Chang G. Y., Mao S. J. T., Chang W. C., The preventive effects of G115 on balloon injury-induced neointima formation in rats Life Sciences 2001 70 6 669 679 (Pubitemid 34056564)
76. Huang H. C., Shi G. Y., Jiang S. J., Shi C. S., Wu C. M., Yang H. Y., Wu H. L., Thrombomodulin-mediated cell adhesion: involvement of its lectin-like domain Journal of Biological Chemistry 2003 278 47 46750 46759
77. Peichev M., Naiyer A. J., Pereira D., Zhu Z., Lane W. J., Williams M., Oz M. C., Hicklin D. J., Witte L., Moore M. A. S., Rafii S., Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors Blood 2000 95 3 952 958 (Pubitemid 30062717)
78. Burt R. K., Loh Y., Pearce W., Beohar N., Barr W. G., Craig R., Wen Y., Rapp J. A., Kessler J., Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases Journal of the American Medical Association 2008 299 8 925 936 (Pubitemid 351397068)
79. Crimi E., Ignarro L. J., Napoli C., Microcirculation and oxidative stress Free Radical Research 2007 41 12 1364 1375 (Pubitemid 350302192)
80. Karra R., Vemullapalli S., Dong C., Herderick E. E., Song X., Slosek K., Nevins J. R., West M., Goldschmidt-Clermont P. J., Seo D., Molecular evidence for arterial repair in atherosclerosis Proceedings of the National Academy of Sciences of the United States of America 2005 102 46 16789 16794 (Pubitemid 41688855)
81. Napoli C., Maione C., Schiano C., Fiorito C., Ignarro L. J., Bone marrow cell-mediated cardiovascular repair: potential of combined therapies Trends in Molecular Medicine 2007 13 7 278 286 (Pubitemid 47023053)
82. Nakamura K., Yamagishi S. I., Matsui T., Yoshida T., Takenaka K., Jinnouchi Y., Yoshida Y., Ueda S. I., Adachi H., Imaizumi T., Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation American Journal of Pathology 2007 170 6 2159 2170 (Pubitemid 47339287)
83. Yamagishi S. I., Inagaki Y., Nakamura K., Abe R., Shimizu T., Yoshimura A., Imaizumi T., Pigment epithelium-derived factor inhibits TNF- -induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation Journal of Molecular and Cellular Cardiology 2004 37 2 497 506 (Pubitemid 38953377)
84. Kao S. T., Yeh C. C., Hsieh C. C., Yang M. D., Lee M. R., Liu H. S., Lin J. G., The Chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest Life Sciences 2001 69 13 1485 1496
85. Fang S. H., Hou Y. C., Chang W. C., Hsiu S. L., Chao P. D. L., Chiang B. L., Morin sulfates/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock Life Sciences 2003 74 6 743 756
86. Liang H., Hou H., Yi W., Increased expression of pigment epithelium-derived factor in aged mesenchymal stem cells impairs their therapeutic efficacy for attenuating myocardial infarction injury. European Heart Journal. In press
87. Ward N. L., LaManna J. C., The neurovascular unit and its growth factors: coordinated response in the vascular and nervous systems Neurological Research 2004 26 8 870 883 (Pubitemid 39628565)
88. Shen Q., Goderie S. K., Jin L., Karanth N., Sun Y., Abramova N., Vincent P., Pumiglia K., Temple S., Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells Science 2004 304 5675 1338 1340 (Pubitemid 38697433)
89. Pumiglia K., Temple S., PEDF: bridging neurovascular interactions in the stem cell niche Nature Neuroscience 2006 9 3 299 300 (Pubitemid 43290955)
90. Ramrez-Castillejo C., Snchez-Snchez F., Andreu-Agull C., Ferrn S. R., Aroca-Aguilar J. D., Snchez P., Mira H., Escribano J., Farias I., Pigment epithelium-derived factor is a niche signal for neural stem cell renewal Nature Neuroscience 2006 9 3 331 339 (Pubitemid 43290962)
91. Palmieri D., Watson J. M., Rinehart C. A., Age-related expression of PEDF/EPC-1 in human endometrial stromal fibroblasts: implications for interactive senescence Experimental Cell Research 1999 247 1 142 147 (Pubitemid 29393970)
92. Tavazoie M., Van der Veken L., Silva-Vargas V., Louissaint M., Colonna L., Zaidi B., Garcia-Verdugo J. M., Doetsch F., A specialized vascular niche for adult neural stem cells Cell Stem Cell 2008 3 3 279 288
93. Shen Q., Wang Y., Kokovay E., Lin G., Chuang S. M., Goderie S. K., Roysam B., Temple S., Adult SVZ stem cells lie in a vascular Niche: a quantitative analysis of Niche cell-cell interactions Cell Stem Cell 2008 3 3 289 300
94. Andreu-Agullo C., Morante-Redolat J. M., Delgado A. C., Vascular niche factor PEDF modulates notch-dependent stemness in the adult subependymal zone Nature Neuroscience 2009 12 12 1514 1523
95. Filleur S., Nelius T., De Riese W., Kennedy R. C., Characterization of pedf: a multi-functional serpin family protein Journal of Cellular Biochemistry 2009 106 5 769 775