T Helper Type 17 Cells Expand in Patients with Myasthenia-Associated Thymoma

Scandinavian Journal of Immunology

Volumn 76, Issue 1, 2012, Pages 54-61

  Wang, Z ^a   Wang, W ^a   Chen, Y ^a   Wei, D ^a  

^a 309TH HOSPITAL OF PLA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR ANTIBODY; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; CELL EXPANSION; CELL POPULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MYASTHENIA GRAVIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REGULATORY T LYMPHOCYTE; TH17 CELL; THYMOMA; THYMUS; THYMUS HYPERPLASIA;

ADULT; AUTOANTIBODIES; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TH17 CELLS; THYMOMA; THYMUS NEOPLASMS;

EID: 84862253578     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2012.02703.x     Document Type: Article

References (35)

1. Meriggioli MN, Sanders DB. Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity. Lancet Neurol 2009;8:475-90.
2. Skeie GO, Romi F. Paraneoplastic myasthenia gravis: immunological and clinical aspects. Eur J Neurol 2008;15:1029-33.
3. Schluep M, Willcox N, Vincent A, Dhoot GK, Newsom-Davis J. Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study. Ann Neurol 1987;22:212-22.
4. Evoli A, Minisci C, Di Schino C et al. Thymoma in patients with MG: characteristics and long-term outcome. Neurology 2002;59:1844-50.
5. Morgenthaler TI, Brown LR, Colby TV, Harper CM Jr, Coles DT. Thymoma. Mayo Clin Proc 1993;68:1110-23.
6. Ströbel P, Rosenwald A, Beyersdorf N et al. Selective loss of regulatory T cells in thymomas. Ann Neurol 2004;56:901-4.
7. Kadota Y, Okumura M, Miyoshi S et al. Altered T cell development in human thymoma is related to impairment of MHC class II transactivator expression induced by interferon-gamma (IFN-gamma). Clin Exp Immunol 2000;121:59-68.
8. Wang HB, Shi FD, Li H, van der Meide PH, Ljunggren HG, Link H. Role for interferon-gamma in rat strains with different susceptibility to experimental autoimmune myasthenia gravis. Clin Immunol 2000;95:156-62.
9. Balandina A, Lécart S, Dartevelle P, Saoudi A, Berrih-Aknin S. Functional defect of regulatory CD4 (+) CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis. Blood 2005;105:735-41.
10. Luther C, Poeschel S, Varga M, Melms A, Tolosa E. Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma. J Neuroimmunol 2005;164:124-8.
11. Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 2008;28:454-67.
12. Dong C. Regulation and pro-inflammatory function of interleukin-17 family cytokine. Immunol 2008;226:80-6.
13. Pène J, Chevalier S, Preisser L et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 2008;180:7423-30.
14. Duerr RH, Taylor KD, Brant SR et al. A genomewide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006;314:1461-3.
15. Wang W, Milani M, Ostlie N et al. C57BL/6 mice genetically deficient in IL-12/IL-23 and IFN-gamma are susceptible to experimental autoimmune myasthenia gravis, suggesting a pathogenic role of non-Th1 cells. J Immunol 2007;178:7072-80.
16. Mu L, Sun B, Kong Q et al. Disequilibrium of T helper type 1, 2 and 17 cells and regulatory T cells during the development of experimental autoimmune myasthenia gravis. Immunology 2009;128 (SUPPL 1):e826-36.
17. Travis WD, Brambilla E, Müller-Hermelink HK et al. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Lyon: IARC Press, 2004. ISBN: 9283224183.
18. Jaretzki A III, Barohn RJ, Ernstoff RM et al. Myasthenia gravis: recommendations for clinical research standards. Task force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. Neurology 2000;55:16-23.
19. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006;24:179-89.
20. Mangan PR, Harrington LE, O'Quinn DB et al. Transforming growth factor-beta induces development of the T (H) 17 lineage. Nature 2006;441:231-4.
21. Bettelli E, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006;441:235-8.
22. + regulatory T cells and Th17 cells in myasthenia gravis patients. J Neuroimmunol 2010;225:123-31.
23. Roche JC, Capablo JL, Larrad L et al. Increased serum interleukin-17 levels in patients with myasthenia gravis. Muscle Nerve 2011;44:278-80.
24. Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007;25:821-52.
25. Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003;278:1910-4.
26. Bettelli E, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006;441:235-8.
27. Kobayashi T, Okamoto S, Hisamatsu T et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut 2008;57:1682-9.
28. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007;8:942-9.
29. Wilson NJ, Boniface K, Chan JR et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007;8:950-7.
30. Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 2009;31:331-41.
31. Barrie A, Khare A, Henkel M et al. Prostaglandin E2 and IL-23 plus IL-1β Differentially Regulate the Th1/Th17 Immune Response of Human CD161 (+) CD4 (+) Memory T Cells. Clin Transl Sci 2011;4:268-73.
32. Rong G, Zhou Y, Xiong Y et al. Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population. Clin Exp Immunol 2009;156:217-25.
33. Shi YH, Shi GC, Wan HY et al. Coexistence of Th1/Th2 and Th17/Treg imbalances in patients with allergic asthma. Chin Med J (Engl) 2011;124:1951-6.
34. + T cells in lupus patients. Clin Rheumatol 2010;29:1251-8.
35. Wang ZK, Wang JH, Deng BQ, Ding SJ, Wu Tao. Reduction of natural regulatory T cells in thymomas accompanying myasthenia gravis and its possible association with Foxp3 and thymic stromal lymphopoietin. J Med Col PLA 2009;24:50-5.