Application of consensus scoring and principal component analysis for virtual screening against β-secretase (BACE-1)

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Liu, Shu ^a   Fu, Rao ^a   Zhou, Li Hua ^a   Chen, Sheng Ping ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA SECRETASE 1; BETA SECRETASE INHIBITOR; S 276065; S 450588; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; SECRETASE;

ARTICLE; BINDING SITE; CONSENSUS SCORING; DRUG SCREENING; FLUORESCENCE RESONANCE ENERGY TRANSFER; MOLECULAR DOCKING; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE ANALYSIS; STATISTICAL ANALYSIS; VIRTUAL REALITY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DEVELOPMENT; ENZYME ACTIVE SITE; GENETICS; HUMAN; METABOLISM; METHODOLOGY; PROTEIN BINDING;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; CATALYTIC DOMAIN; DRUG DISCOVERY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; MODELS, MOLECULAR; PRINCIPAL COMPONENT ANALYSIS; PROTEIN BINDING; RESEARCH DESIGN;

EID: 84862224304     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038086     Document Type: Article

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