Synthesis and cytotoxicity of 3,4-disubstituted-5-(3,4,5-trimethoxyphenyl)- 4H-1,2,4-triazoles and novel 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 13, 2012, Pages 4471-4474

  Zhao, Pei Liang ^a   Duan, An Na ^a   Zou, Min ^a   Yang, Hai Kui ^a   You, Wen Wei ^a   Wu, Shu Guang ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

5,6 Dihydro 1,2,4 triazolo 3,4 b 1,3,4 thiadiazole; Antitumor activity; Synthesis

Indexed keywords

2 [6 (2,4 DIMETHOXYPHENYL) 3 (3,4,5 TRIMETHOXYPHENYL) 5,6 DIHYDRO [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 6 YL] 1 4 TOLYLETHANONE; 2 [6 PHENYL 3 (3,4,5 TRIMETHOXYPHENYL) 5,6 DIHYDRO [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 6 YL] 1 4 TOLYLETHANONE; 3,4 DISUBSTITUTED 5 (3,4,5 TRIMETHOXYPHENYL) 4H 1,2,4 TRIAZOLE DERIVATIVE; ANTINEOPLASTIC AGENT; DOXORUBICIN; ETHYL 2 [6 PHENYL 3 (3,4,5 TRIMETHOXYPHENYL) 5,6 DIHYDRO [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 6 YL]ACETATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HEP G2 CELLS; HUMANS; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; TRIAZOLES;

EID: 84862210967     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.023     Document Type: Article

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