Synthesis and antiproliferative evaluation of 3,5-disubstituted 1,2,4-triazoles containing flurophenyl and trifluoromethanephenyl moieties

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5358-5362

  Wang, Li Ya ^a   Tseng, Wen Che ^a   Wu, Tian Shung ^a   Kaneko, Kimiyoshi ^b   Takayama, Hiroyuki ^b   Kimura, Masayuki ^b   Yang, Wen Chin ^c   Wu, Jin Bin ^a   Juang, Shin Hun ^a   Wong, Fung Fuh ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

^c AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

Author keywords

1,2,4 Triazoles; Aldehydes; Antiproliferative activity; Cycloaddition; Fluorine containing compounds; Nitrilimine

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; FLUORINE; FLUOROFORM; METHYL 1 (4 FLUOROPHENYL) 5 METHYL 1H 1,2,4 TRIAZOLE 3 CARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER INHIBITION; CATALYSIS; CELL PROLIFERATION; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; CYCLIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 80051950045     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.009     Document Type: Article

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