New CD1d agonists: Synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 13, 2012, Pages 4348-4352

  Jervis, Peter J ^a   Graham, Lisa M ^b   Foster, Erin L ^b   Cox, Liam R ^a   Porcelli, Steven A ^b   Besra, Gurdyal S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

GalCer; CD1d; Click chemistry; iNKT cell; Triazole

Indexed keywords

6'' AZIDO 6'' DEOXY ALPHA GALACTOSYLCERAMIDE; CD1D ANTIGEN; CERAMIDE DERIVATIVE; GAMMA INTERFERON; INTERLEUKIN 2; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; CYCLOADDITION; CYTOKINE RELEASE; IN VITRO STUDY; IN VIVO STUDY; SYNTHESIS; TH1 CELL; TH2 CELL;

ANIMALS; ANTIGENS, CD1D; CELL LINE; GALACTOSYLCERAMIDES; HYBRIDOMAS; INJECTIONS, INTRAPERITONEAL; INTERFERON-GAMMA; INTERLEUKIN-2; INTERLEUKIN-4; MICE; NATURAL KILLER T-CELLS; TRIAZOLES;

EID: 84862204329     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.009     Document Type: Article

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