Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site

Journal of Neurochemistry

Volumn 122, Issue 1, 2012, Pages 38-47

  Dutertre, Sébastien ^a,c   Drwal, Malgorzata ^a,d   Laube, Bodo ^a,b   Betz, Heinrich ^a,e  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^b DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

agonist binding; GluCl; glycine receptors; homology modeling; ligand gated ion channel; site directed mutagenesis

Indexed keywords

CHLORIDE CHANNEL; GLYCINE RECEPTOR; GLYCINE RECEPTOR AGONIST; GLYCINE RECEPTOR ALPHA1; GLYCINE RECEPTOR BETA; LIGAND GATED ION CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ION EXCHANGE; MOLECULAR DOCKING; MOLECULAR PROBE; NONHUMAN; OOCYTE; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TARGETING; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; COMPUTER SIMULATION; COPPER; ETHANOL; GLYCINE AGENTS; INHIBITORY CONCENTRATION 50; IVERMECTIN; MEMBRANE POTENTIALS; MICROINJECTIONS; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; NORTROPANES; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RECEPTORS, GLYCINE; XENOPUS LAEVIS; ZINC;

EID: 84862197888     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07755.x     Document Type: Article

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