High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase

Journal of Biomolecular Screening

Volumn 17, Issue 6, 2012, Pages 738-751

  Preuss, Janina ^a,b,c   Hedrick, Michael ^c   Sergienko, Eduard ^c   Pinkerton, Anthony ^c   Mangravita Novo, Arianna ^c   Smith, Layton ^c   Marx, Carolin ^a   Fischer, Elisabeth ^b   Jortzik, Esther ^b   Rahlfs, Stefan ^b   Becker, Katja ^b   Bode, Lars ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c BURNHAM INSTITUTE   (United States)

Author keywords

glucose 6 phosphate dehydrogenase; high throughput screening; malaria; pentose phosphate pathway; Plasmodium

Indexed keywords

CB 103; CB 104; CB 22; CB 30; CB 44; CB 47; CB 61; CB 62; CB 63; CB 64; CB 68; CB 70; CB 83; CB 90; ENZYME INHIBITOR; GLUCOSE 6 PHOSPHATE DEHYDROGENASE 6 PHOSPHOGLUCONOLACTONASE; MICROBIAL ENZYME; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FOLLOW UP; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANTIMALARIALS; CARBOXYLIC ESTER HYDROLASES; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; GLUCOSEPHOSPHATE DEHYDROGENASE; HEPATOCYTES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INHIBITORY CONCENTRATION 50; MALARIA, FALCIPARUM; MULTIENZYME COMPLEXES; PLASMODIUM FALCIPARUM; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862183837     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057112442382     Document Type: Article

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