Pyrimidine-2,4,6-triones: A new effective and selective class of matrix metalloproteinase inhibitors

Biological Chemistry

Volumn 382, Issue 8, 2001, Pages 1277-1285

  Grams, F ^a   Brandstetter, H ^a   D'Alo S ^a   Geppert, D ^a   Krell, H W ^a   Leinert, H ^a   Livi, V ^a   Menta, E ^a   Oliva, A ^a   Zimmermann, G ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Barbiturate; Cancer; Drug design; Gelatinase; Inhibitor; Matrix metalloproteinase

Indexed keywords

BATIMASTAT; GELATINASE A; GELATINASE B; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; PEPTIDE; PHOSPHINIC ACID DERIVATIVE; PRINOMASTAT; PROTEINASE; PYRIMIDINE 2,4,6 TRIONE; RO 28 2653; TANOMASTAT; THIOL DERIVATIVE; UNCLASSIFIED DRUG; ZINC PROTEINASE;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; IC 50; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

CHELATING AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 8; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; PROTEASE INHIBITORS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17944374569     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2001.159     Document Type: Article

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