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Volumn 899, Issue , 2012, Pages 46-56
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Simultaneous determination of dextromethorphan, dextrorphan and doxylamine in human plasma by HPLC coupled to electrospray ionization tandem mass spectrometry: Application to a pharmacokinetic study
a
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Author keywords
LC MS MS; Quantification; Volunteer
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Indexed keywords
ANALYTES;
ANALYTICAL COLUMNS;
ANALYTICAL PROCEDURE;
CALIBRATION CURVES;
CHROMATOGRAPHIC SEPARATIONS;
DEXTROMETHORPHAN;
DEXTROMETHORPHAN HYDROBROMIDE;
DEXTRORPHAN;
ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY;
HIGH SENSITIVITY;
HIGH-THROUGHPUT ANALYSIS;
HPLC-ESI-MS/MS;
HUMAN PLASMAS;
INTERNAL STANDARDS;
LC-MS/MS;
LIQUID-LIQUID EXTRACTION;
MOBILE PHASE;
ORAL DOSE;
PHARMACOKINETIC STUDIES;
QUANTIFICATION;
ROBUST METHODS;
RUNTIMES;
SIMULTANEOUS DETERMINATIONS;
VOLUNTEER;
CHROMATOGRAPHY;
DEUTERIUM;
DRUG PRODUCTS;
ELECTROSPRAY IONIZATION;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
MASS SPECTROMETRY;
PHARMACOKINETICS;
PLASMA (HUMAN);
PLASMAS;
DEXTROMETHORPHAN;
DEXTRORPHAN;
DOXYLAMINE;
ACCURACY;
AREA UNDER THE CURVE;
ARTICLE;
CALIBRATION;
DRUG BLOOD LEVEL;
DRUG ISOLATION;
DRUG STRUCTURE;
ELECTROSPRAY MASS SPECTROMETRY;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HIGH THROUGHPUT SCREENING;
HUMAN;
MAXIMUM PLASMA CONCENTRATION;
PRIORITY JOURNAL;
QUALITY CONTROL;
SENSITIVITY AND SPECIFICITY;
TANDEM MASS SPECTROMETRY;
TIME TO MAXIMUM PLASMA CONCENTRATION;
ADOLESCENT;
ADULT;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
DEXTROMETHORPHAN;
DEXTRORPHAN;
DOXYLAMINE;
FEMALE;
HUMANS;
MALE;
MIDDLE AGED;
SENSITIVITY AND SPECIFICITY;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
TANDEM MASS SPECTROMETRY;
YOUNG ADULT;
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EID: 84862144871
PISSN: 15700232
EISSN: 1873376X
Source Type: Journal
DOI: 10.1016/j.jchromb.2012.05.001 Document Type: Article |
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Times cited : (19)
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References (26)
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