Comparative pharmacokinetics of single doses of doxylamine succinate following intranasal, oral and intravenous administration in rats

Biopharmaceutics and Drug Disposition

Volumn 23, Issue 6, 2002, Pages 239-244

  Pelser, Andries ^a   Müller, Douw G ^a   Plessis, Jeanetta Du ^a   Du Preez, Jan L ^a   Goosen, Colleen ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Doxylamine succinate; Intranasal; Intravenous; Oral; Pharmacokinetics

Indexed keywords

ALFENTANIL; DOXYLAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; ISOTONIC SOLUTION; MEPYRAMINE MALEATE; MIDAZOLAM; NAFARELIN; NEOSTIGMINE; PROGESTERONE; PROPRANOLOL;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIEMETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NAUSEA AND VOMITING; NONHUMAN; NOSE DISEASE; NOSE MUCOSA; RAT; STATISTICAL ANALYSIS;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOXYLAMINE; HISTAMINE H1 ANTAGONISTS; INJECTIONS, INTRAVENOUS; MALE; NASAL MUCOSA; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036739182     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.314     Document Type: Article

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