Tandem mass spectrometry (LC-MS-MS): A predominant role in bioassays for pharmacokinetic studies

Arzneimittel-Forschung/Drug Research

Volumn 57, Issue 2, 2007, Pages 122-128

  Marzo, Antonio ^a   Dal Bo, Lorenzo ^a  

^a IPAS SA   (Switzerland)

Author keywords

Gas chromatography; Liquid chromatography; Tandem mass spectrometry, bioassays, limit of quantification, plasma concentrations

Indexed keywords

ACICLOVIR; AMLODIPINE; BUDESONIDE; DICLOFENAC; DIHYDROERGOCRYPTINE; ENALAPRIL; ENALAPRILAT; FORMOTEROL; IBUPROFEN; ISOSORBIDE 5 NITRATE; KETOPROFEN; LIDOCAINE; LORAZEPAM; MORPHINE; NAPROXEN; NIFEDIPINE; NIMESULIDE; NITRENDIPINE; PICOSULPHATE; PIROXICAM; PROCHLORPHENAZINE; PRODRUG; SULFUR DERIVATIVE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; BIOASSAY; DRUG BLOOD LEVEL; DRUG HALF LIFE; GAS CHROMATOGRAPHY; HUMAN; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; REVIEW; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 33847758698     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296593     Document Type: Review

References (20)

1. Marzo A. Clinical pharmacokinetic registration file for NDA and ANDA procedures. Pharmacol Res. 1997;36(6):425-450.
2. Marzo A. Chromatographic methods and selective detectors in pharmacokinetics. Boll Chim Farm. 1989;128(2):45-53.
3. EMEA Note for guidance on the investigation of bioavailability and bioequivalence. CPMP/EWP/QWP/1401/98, January 2002.
4. US FDA. unavailability and bioequivalence studies for orally administered drug products. General considerations. CDER, July 2002.
5. Marzo A, Ceppi Monti N, Vuksic D. Experimental, extrapolated and truncated areas under the concentration-time curve in bioequivalence trials. Eur J Clin Pharmacol. 1999;55(9):627-631.
6. Marzo A. Open questions on bioequivalence: some problems and some solutions. Pharmacol Res. 1999;40(4):357-368.
7. Marzo A, Treffner E. Gas-liquid chromatographic determination of isosorbide-5-mononitrate derivatized with perfluorinated anhydrides for pharmacokinetic and bioavailability investigations. J Chromatogr. 1985;345(2):390-395.
8. Marzo A. Bioequivalence behind the scenes. Pharm Dev Regul. 2003;1(3):179-189.
9. Osterwalder A, Reiner V, Reiner G, Lualdi P. Tissue absorption and distribution of ketoprofen after patch application in subjects undergoing knee arthroscopy or endoscopic carpal ligament release. Arzneimittel-Forschung (Drug Research). 2002;52(11):822-827.
10. Dal Bo L, Mazzucchelli P, Marzo A. Highly sensitive bioassay of lidocaine in human plasma by high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr A. 1999;854(1-2):3-11.
11. Marzo A, Monti NC, Tettamanti RA, Crivelli F, Dal Bo L, Mazzucchelli P, et al. Bioequivalence of inhaled formoterol fumarate assessed from pharmacodynamic, safety and urinary pharmacokinetic data. Arzneimittel- Forschung (Drug Research). 2000;50(6):559-563.
12. Häring N, Salama Z, Jaeger H. Triple stage quadrupole mass spectrometric determination of bromocriptine in human plasma with negative ion chemical ionization. Arzneimittel-Forschung (Drug Research). 1988;38(10):1529-1532.
13. Marzo A. Incoming guidelines on chirality. A challenge for pharmacokinetics in drug development. Arzneimittel-Forschung (Drug Research). 1994;44(6):791-793.
14. Marzo A, Heftmann E. Enantioselective analytical methods in pharmacokinetics with specific reference to genetic polymorphic metabolism. J Biochem Biophys Methods. 2002;54(1-3):57-70.
15. Amidon GL, Lennernäs H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res. 1995;12(3):413-420.
16. Law B, Temesi D. Factors to consider in the development of generic bioanalytical high-performance liquid chromatographic-mass spectrometric methods to support drug discovery. J Chromatogr B. 2000;748(1):21-30.
17. Ackermann BL, Berna MJ, Murphy AT. Recent advances in use of LC/MS/MS for quantitative high-throughput bioanalytical support of drug discovery. Curr Top Med Chem. 2002;2(1):53-66.
18. Marzo A, Dal Bo L, Mazzucchelli P, Monti NC, Crivelli F, Ismaili S, et al. Amlodipine bioequivalence achieved with a very sensitive liquid chromatography tandem mass spectrometric bioassay. Arzneimittel-Forschung (Drug Research). 2000;50(8):688-694.
19. Dal Bo L, Mazzucchelli P, Marzo A. Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B. 2000;749(2):287-294.
20. Marzo A, Dal Bo L, Mazzucchelli P, Monti NC, Crivelli F, Ismaili S, et al. Pharmacokinetic and pharmacodynamic comparative study of zofenopril and enalapril in healthy volunteers. Arzneimittel-Forschung (Drug Research). 2002;52(4):233-242.