Determination of dextrorphan in human plasma and pharmacokinetic study

Yaoxue Xuebao

Volumn 39, Issue 6, 2004, Pages 449-452

  Liu, Dan ^a   Chen, Xiao Yan ^a   Zhang, Yi Fan ^a   Zhong, Da Fang ^a   Cu, Qi ^a   Zhang, Yong ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Dextromethorphan; Dextrorphan; Liquid chromatography tandem mass spectrometry; Pharmacokinetics; Plasma concentration

Indexed keywords

DEXTRORPHAN;

ARTICLE; CALIBRATION; DRUG BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; NORMAL HUMAN; SENSITIVITY AND SPECIFICITY;

ADMINISTRATION, ORAL; ADULT; AREA UNDER CURVE; DEXTROMETHORPHAN; DEXTRORPHAN; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THERAPEUTIC EQUIVALENCY;

EID: 7044226063     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Parfitt K, Sweetman SC, Blake PS, et al. Martindale, the Extra Pharmacopoeia [S]. 32nd Ed. London: The Pharmaceutical Press, 1999. 1571.
2. Ramachander G, Williams FD, Emele JF. Determination of dextrorphan in plasma and evaluation of bioavailability of dextromethorphan hydrobromide in humans [J]. J Pharm Sci, 1977,66(7):1047-1048.
3. Eichhold TH, Greenfield LJ, Hoke SH, et al. Determination of dextromethorphan and dextrorphan in human plasma by liquid chromatography/tandem mass spectrometry [J]. J Mass Spectrom, 1997,32(11):1205-1211.
4. Liu LL, Wang Z, Feng XT, et al. Column switching HPLC method for determination of dextrorphan, an active metabolite of dextromethorphan, in plasma [J]. Acta Pharm Sin, 1993,28(5):374-378.
5. Chladek J, Zimova G, Beranek M, et al. In vivo indices of CYP2D6 activity: comparison of dextromethorphan metabolic ratios in 4 h urine and 3 h plasma [J]. Eur J Clin Pharmacol, 2000,56(9-10):651-657.
6. Mascher H. High performance liquid chromatographic determination of dextrorphan and 3-hydroxymorphinan in human plasma based on a selective pre-column sample clean-up [J]. J Chromatogr B, 1987,420(1):217-222.
7. East T, Dye D. Determination of dextromethorphan and metabolites in human plasma and urine by high-performance liquid chromatography with fluorescence detection [J]. J Chromatogr B, 1985,338(1):99-112.
8. Chen ZR, Somogyi AA, Bochner F. Simultaneous determination of dextromethorphan and three metabolites in plasma and urine using high-performance liquid chromatography with application to their disposition in man [J]. Ther Drug Monit, 1990,12(1):97-104.
9. Zhong DF. Some aspects in establishing standard curves in bioanalyses with the weighted least squires method [J]. Chin J Pharm Anal, 1996,16 (5):343-346.
10. Shah VP, Midha KK, Findlay JWA, et al. Bioanalytical method validation-a revisit with a decade of progress [J]. Pharm Res, 2000,17(12):1551-1557.
11. Du Y, Zhong DF, Zhao LM, et al. Studies on pharmacokinetics of Yu-mei dissoluble tablets and bioequivalence of its two formulations [J]. J Shenyang Pharm Univ, 2001, 18(3):157 -161.