Pharmacokinetic comparison of a delayed- release combination of doxylamine succinate and pyridoxine hydrochloride (diclectin®) and oral solutions of these drugs in healthy women of childbearing age

Canadian Journal of Clinical Pharmacology

Volumn 16, Issue 3, 2009, Pages

  Nulman, Irena ^a   Koren, Gideon ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Doxylamine succinate; Nausea and vomiting of pregnancy; Pharmacokinetics; Pregnancy; Pyridoxal, pyridoxamine, pyridoxal 5 phosphate; Pyridoxine chloride

Indexed keywords

BENDECTIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DELAYED DRUG RELEASE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; FEMALE; HUMAN; PHARMACOKINETICS; RANDOMIZED CONTROLLED TRIAL;

EID: 73249133745     PISSN: 1198581X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

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2. Levichek Z, Atanackovic G, Oepkes D, Maltepe C, Einarson A, Magee L, Koren G. Nausea and vomiting of pregnancy. Evidence-based treatment algorithm. Can Fam Physician 2002 Feb; 48:267-8, 277.
3. Magee LA, Mazzotta P, Koren G. Evidence-based view of safety and effectiveness of pharmacologic therapy for nausea and vomiting of pregnancy (NVP). Am J Obstet Gynecol. 2002 May; 186(5):S256-61.
4. Bishai R, Mazzotta P, Atanackovic G, Levichek Z, Pole M, Magee LA, Koren G. Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of diclectin (doxylmaine-B6). Can J Clin Pharmacol. 2000 Autumn; 7(3):138-43.
5. Brent RL. Bendectin: review of the medical literature of a comprehensively studied human nonteratogen and the most prevalent tortogenlitigen. Reprod Toxicol. 1995;39337-49.
6. Brent R. Bendectin and birth defects: hopefully, the final chapter. Birth Defects Res A Clin Mol Teratol. 2003 Feb; 67(2):79-87.
7. Ornstein M, Einarson A, Koren G. Bendectin/diclectin for morning sickness; a Canadian follow-up of an American tragedy Reprod Toxicol. 1995 Jan-Feb; 9(1):1-6.
8. Boskovic R, Einarson A, Maltepe C, Wolpin J, Koren G. Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing. J Obstet Gynaecol Can. 2003 Oct; 25(10):830-3.
9. Koren G, Maltepe C. Pre-emptive therapy for severe nausea and vomiting of pregnancy and hyperemesis gravidarum. J Obstet Gynaecol. 2004 Aug; 24(5):530-3.
10. Atanackovic G, Navioz Y, Moretti ME, Koren G. The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy. J Clin Pharmacol. 2001 Aug; 41(8):842-5.