Nanonization of methotrexate by solution-enhanced dispersion by supercritical CO 2

Journal of Supercritical Fluids

Volumn 67, Issue , 2012, Pages 7-13

  Chen, Ai Zheng ^a   Li, Li ^a   Wang, Shi Bin ^a   Zhao, Chen ^a   Liu, Yuan Gang ^a   Wang, Guang Ya ^a   Zhao, Zheng ^b  

^a HUAQIAO UNIVERSITY   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Methotrexate; Nanoparticles; Nonsolvent; Supercritical CO 2

Indexed keywords

CHEMICAL COMPOSITIONS; DISSOLUTION RATES; FACTORIAL EXPERIMENT; MEAN PARTICLE SIZE; MEAN SIZE; METHOTREXATE; MOLECULAR LEVELS; NON-SOLVENTS; OPERATING PARAMETERS; PHYSICAL STATE; POORLY WATER-SOLUBLE DRUGS; SMOOTH SURFACE; SPHERICAL SHAPE; STRUCTURAL CHANGE; SUPER-CRITICAL; SUPERCRITICAL CO;

BIOCHEMISTRY; CARBON DIOXIDE; DISPERSIONS; DISSOLUTION; NANOPARTICLES; PARTICLE SIZE ANALYSIS; SOLUBILITY;

PARTICLE SIZE;

EID: 84862103644     PISSN: 08968446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.supflu.2012.03.004     Document Type: Article

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