Influence of pressure, temperature and concentration on the mechanisms of particle precipitation in supercritical antisolvent micronization

Journal of Supercritical Fluids

Volumn 58, Issue 2, 2011, Pages 295-302

  De Marco, Iolanda ^a   Reverchon, Ernesto ^a  

^a UNIVERSITY OF SALERNO   (Italy)

Author keywords

Gas mixing phenomena; Jet break up; Particle formation mechanisms; Supercritical antisolvent process

Indexed keywords

DYNAMIC SURFACE TENSIONS; EXPERIMENTAL EVIDENCE; GAS-MIXING; GASEOUS PHASE; JET BREAK-UP; LIQUID DROPLETS; LIQUID SOLUTION; MEAN DIAMETER; MICRO-DROPLET; MICRO-PARTICLES; MICRONIZATIONS; MODEL COMPOUND; NANOMETRIC RANGES; PARTICLE DIAMETERS; PARTICLE FORMATION MECHANISMS; PARTICLE PRECIPITATION; PRECIPITATION MECHANISM; PRECIPITATION PROCESS; PRECIPITATION TEMPERATURE; PROCESS PARAMETERS; SPECIFIC VALUES; STARTING SOLUTIONS; SUPERCRITICAL ANTISOLVENT PROCESS; SUPERCRITICAL ANTISOLVENTS;

GADOLINIUM; LIQUIDS; NANOPARTICLES; SUPERCRITICAL FLUID EXTRACTION; SURFACE TENSION;

PRECIPITATION (CHEMICAL);

EID: 80051475564     PISSN: 08968446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.supflu.2011.06.005     Document Type: Article

References (31)

1. A. Shariati, and C.J. Peters Recent developments in particle design using supercritical fluids Current Opinion in Solid State & Materials Science 7 4-5 2003 371 383 (Pubitemid 38462044)
2. Y. Hakuta, H. Hayashi, and K. Arai Fine particle formation using supercritical fluids Current Opinion in Solid State & Materials Science 7 4-5 2003 341 351 (Pubitemid 38462041)
3. E. Reverchon Supercritical antisolvent precipitation of micro- and nano-particles J. Supercritical Fluids 15 1 1999 1 21 (Pubitemid 129671809)
4. E. Reverchon, E. Torino, S. Dowy, A. Braeuer, and A. Leipertz Interactions of phase equilibria, jet fluid dynamics and mass transfer during supercritical antisolvent micronization Chemical Engineering J. 156 2 2010 446 458
5. E. Elizondo, A. Córdoba, S. Sala, N. Ventosa, and J. Veciana Preparation of biodegradable poly (methyl vinyl ether-co-maleic anhydride) nanostructured microparticles by precipitation with a compressed antisolvent J. Supercritical Fluids 53 1-3 2010 108 114
6. E. Reverchon, I. De Marco, and E. Torino Nanoparticles production by supercritical antisolvent precipitation: a general interpretation J. Supercritical Fluids 43 1 2007 126 138 (Pubitemid 47385121)
7. E. Reverchon, R. Adami, G. Caputo, and I. De Marco Spherical microparticles production by supercritical antisolvent precipitation: interpretation of results J. Supercritical Fluids 47 1 2008 70 84
8. E. Reverchon, I. De Marco, R. Adami, and G. Caputo Expanded micro-particles by supercritical antisolvent precipitation: interpretation of results J. Supercritical Fluids 44 1 2008 98 108 (Pubitemid 350298724)
9. E. Torino, I. De Marco, and E. Reverchon Organic nanoparticles recovery in supercritical antisolvent precipitation J. Supercritical Fluids 55 2010 300 306
10. 2-philic antisolvents AIChE J. 46 9 2000 1850 1859
11. E. Reverchon, I. De Marco, and G. Della Porta Rifampicin microparticles production by supercritical antisolvent precipitation International J. Pharmaceutics 243 2002 83 91
12. E. Reverchon, and I. De Marco Supercritical antisolvent micronization of cefonicid: thermodynamic interpretation of results J. Supercritical Fluids 31 2 2004 207 215
13. A. Tenorio, M.D. Gordillo, C. Pereyra, and E.J. Martinez de la Ossa Controlled submicro particle formation of ampicillin by supercritical antisolvent precipitation J. Supercritical Fluids 40 2 2007 308 316 (Pubitemid 46162140)
14. M.-S. Kim, S. Lee, J.-S. Park, J.-S. Woo, and S.-J. Hwang Micronization of cilostazol using supercritical antisolvent (SAS) process: effect of process parameters Powder Technology 177 2 2007 64 70 (Pubitemid 47224964)
15. I. De Marco, and E. Reverchon Supercritical antisolvent micronization of cyclodextrins Powder Technology 183 2 2008 239 246 (Pubitemid 351384803)
16. C.S. Lengsfeld, J.P. Delplanque, V.H. Barocas, and T.W. Randolph Mechanism governing microparticle morphology during precipitation by a compressed antisolvent: atomization vs. nucleation and growth J. Physical Chemistry B 104 2000 2725 2735 (Pubitemid 33685490)
17. E. Badens, O. Boutin, and G. Charbit Laminar jet dispersion and jet atomization in pressurized carbon dioxide J. Supercritical Fluids 36 1 2005 81 90 (Pubitemid 41313015)
18. A. Gokhale, B. Khusid, R.N. Dave, and R. Pfeffer Effect of solvent strength and operating pressure on the formation of submicrometer polymer particles in supercritical microjets J. Supercritical Fluids 43 2 2007 341 356 (Pubitemid 47532379)
19. D.L. Obrzut, P.W. Bell, C.B. Roberts, and S.R. Duke Effect of process conditions on the spray characteristics of a PLA plus methylene chloride solution in the supercritical antisolvent precipitation process J. Supercritical Fluids 42 2 2007 299 309 (Pubitemid 46898737)
20. J.O. Werling, and P.G. Debenedetti Numerical modeling of mass transfer in the supercritical antisolvent process J. Supercritical Fluids 16 2 1999 167 181
21. J.O. Werling, and P.G. Debenedetti Numerical modeling of mass transfer in the supercritical antisolvent process: miscible conditions J. Supercritical Fluids 18 1 2000 11 24
22. F. Chavez, P.G. Debenedetti, J.J. Luo, R.N. Dave, and R. Pfeffer Estimation of the characteristic time scales in the supercritical antisolvent process Industrial & Engineering Chemical Research 42 13 2003 3156 3162 (Pubitemid 36736694)
23. S.S. Dukhin, Y. Shen, R. Dave, and R. Pfeffer Droplet mass transfer, intradroplet nucleation and submicron particle production in two-phase flow of solvent-supercritical antisolvent emulsion Colloids and Surfaces A: Physicochemical and Engineering Aspects 261 2005 163 176 (Pubitemid 40719026)
24. 2 J. Supercritical Fluids 27 2003 73 83
25. S.-C. Chang, M.-J. Lee, and H.-M. Lin Role of phase behavior in micronization of lysozyme via a supercritical anti-solvent process Chemical Engineering J. 139 2008 416 425
26. E. Reverchon, and I. De Marco Mechanisms controlling supercritical antisolvent precipitate morphology Chemical Engineering J. 169 2011 358 370
27. E. Reverchon, G. Caputo, and I. De Marco Role of phase behavior and atomization in the supercritical antisolvent precipitation Industrial & Engineering Chemical Research 42 2003 6406 6414 (Pubitemid 37517538)
28. E. Reverchon, and I. De Marco Supercritical antisolvent precipitation of cephalosporins Powder Technology 164 3 2006 139 146 (Pubitemid 43870362)
29. E. Reverchon, I. De Marco, and G. Della Porta Tailoring of nano- and micro-particles of some superconductor precursors by supercritical antisolvent precipitation J. Supercritical Fluids 23 2002 81 87
30. A.E. Andreatta, L.J. Florusse, S.B. Bottini, and C.J. Peters Phase equilibria of dimethyl sulfoxide (DMSO) + carbon dioxide, and DMSO + carbon dioxide + water mixtures J. Supercritical Fluids 42 2007 60 68 (Pubitemid 46771109)
31. S Dowy, A. Braeuer, K. Reinhold-López, and A. Leipertz Laser analyses of mixture formation and the influence of solute on particle precipitation in the SAS process J. Supercritical Fluids 50 2009 265 275