Transnasal delivery of methotrexate to brain tumors in rats: A new strategy for brain tumor chemotherapy

Molecular Pharmaceutics

Volumn 7, Issue 5, 2010, Pages 1561-1568

  Shingaki, Tomotaka ^a   Inoue, Daisuke ^b   Furubayashi, Tomoyuki ^b   Sakane, Toshiyasu ^c   Katsumi, Hidemasa ^c   Yamamoto, Akira ^c   Yamashita, Shinji ^d  

^a ADME Research Inc   (Japan)

^b SHUJITSU UNIVERSITY   (Japan)

^c KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^d SETSUNAN UNIVERSITY   (Japan)

Author keywords

9L glioma cell; brain delivery; cerebrospinal fluid; inoculation; Methotrexate; nasal absorption

Indexed keywords

ACETAZOLAMIDE; METHOTREXATE; METHOTREXATE DERIVATIVE; METHOTREXATE H 3; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MECHANISM; DRUG TRANSPORT; DRUG UPTAKE; GLIOMA; GLIOMA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; LIQUID SCINTILLATION COUNTING; MALE; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR VOLUME;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CELL LINE, TUMOR; GLIOMA; INJECTIONS, INTRAPERITONEAL; MALE; METHOTREXATE; MODELS, BIOLOGICAL; RATS; RATS, WISTAR;

EID: 77957725049     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900275s     Document Type: Article

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